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N1-Methylnicotinamide : Is It Time to Consider as a Dietary Supplement for Athletes?

Nejabati, Hamid Reza ; Ghaffari-Novin, Mahsa ; Fathi-Maroufi, Nazila ; Faridvand, Yousef ; Holmberg, Hans-Christer LU ; Hansson, Ola LU orcid ; Nikanfar, Saba and Nouri, Mohammad (2022) In Current Pharmaceutical Design 28(10). p.800-805
Abstract

Exercise is considered to be a "medicine" due to its modulatory roles in metabolic disorders such as diabetes and obesity. The intensity and duration of exercise determine the mechanism of energy production by various tissues of the body, especially by muscles, in which the requirement for adenosine triphosphate (ATP) increases by as much as 100-fold. Naturally, athletes try to improve their exercise performance by dietary supplementation with, e.g., vitamins, metabolites, and amino acids. MNAM, as a vitamin B3 metabolite, reduces serum levels and liver contents of triglycerides, and cholesterol and induces lipolysis. It stimulates gluconeogenesis and prohibits liver cholesterol and fatty acid synthesis through the expression of... (More)

Exercise is considered to be a "medicine" due to its modulatory roles in metabolic disorders such as diabetes and obesity. The intensity and duration of exercise determine the mechanism of energy production by various tissues of the body, especially by muscles, in which the requirement for adenosine triphosphate (ATP) increases by as much as 100-fold. Naturally, athletes try to improve their exercise performance by dietary supplementation with, e.g., vitamins, metabolites, and amino acids. MNAM, as a vitamin B3 metabolite, reduces serum levels and liver contents of triglycerides, and cholesterol and induces lipolysis. It stimulates gluconeogenesis and prohibits liver cholesterol and fatty acid synthesis through the expression of sirtuin1 (SIRT1). It seems that MNAM is not responsible for the actions of NNMT in the adipose tissues as MNAM inhibits the activity of NNMT in the adipose tissue and acts like inhibitors of its activity. NNMT-MNAM axis is more activated in the muscles of participants who were undergoing the high-volume-low-intensity exercise and caloric restriction. Therefore, MNAM could be an important myokine during exercise and fasting where it provides the required energy for muscles through the induction of lipolysis and gluconeogenesis in the liver and adipose tissues, respectively. Increased levels of MNAM in exercise and fasting led us to propose that the consumption of MNAM during training especially endurance training could boost exercise capacity and improves performance. Therefore, in this review, we shed light on the potential of MNAM as a dietary supplement in sports medicine.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Pharmaceutical Design
volume
28
issue
10
pages
800 - 805
publisher
Bentham Science Publishers
external identifiers
  • scopus:85130182574
  • pmid:35152860
ISSN
1381-6128
DOI
10.2174/1381612828666220211151204
language
English
LU publication?
yes
additional info
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
id
53b7411e-6fe9-4a1b-bc5f-8d8a27bd7728
date added to LUP
2022-02-18 13:17:50
date last changed
2024-06-13 15:15:58
@article{53b7411e-6fe9-4a1b-bc5f-8d8a27bd7728,
  abstract     = {{<p>Exercise is considered to be a "medicine" due to its modulatory roles in metabolic disorders such as diabetes and obesity. The intensity and duration of exercise determine the mechanism of energy production by various tissues of the body, especially by muscles, in which the requirement for adenosine triphosphate (ATP) increases by as much as 100-fold. Naturally, athletes try to improve their exercise performance by dietary supplementation with, e.g., vitamins, metabolites, and amino acids. MNAM, as a vitamin B3 metabolite, reduces serum levels and liver contents of triglycerides, and cholesterol and induces lipolysis. It stimulates gluconeogenesis and prohibits liver cholesterol and fatty acid synthesis through the expression of sirtuin1 (SIRT1). It seems that MNAM is not responsible for the actions of NNMT in the adipose tissues as MNAM inhibits the activity of NNMT in the adipose tissue and acts like inhibitors of its activity. NNMT-MNAM axis is more activated in the muscles of participants who were undergoing the high-volume-low-intensity exercise and caloric restriction. Therefore, MNAM could be an important myokine during exercise and fasting where it provides the required energy for muscles through the induction of lipolysis and gluconeogenesis in the liver and adipose tissues, respectively. Increased levels of MNAM in exercise and fasting led us to propose that the consumption of MNAM during training especially endurance training could boost exercise capacity and improves performance. Therefore, in this review, we shed light on the potential of MNAM as a dietary supplement in sports medicine.</p>}},
  author       = {{Nejabati, Hamid Reza and Ghaffari-Novin, Mahsa and Fathi-Maroufi, Nazila and Faridvand, Yousef and Holmberg, Hans-Christer and Hansson, Ola and Nikanfar, Saba and Nouri, Mohammad}},
  issn         = {{1381-6128}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{10}},
  pages        = {{800--805}},
  publisher    = {{Bentham Science Publishers}},
  series       = {{Current Pharmaceutical Design}},
  title        = {{N1-Methylnicotinamide : Is It Time to Consider as a Dietary Supplement for Athletes?}},
  url          = {{http://dx.doi.org/10.2174/1381612828666220211151204}},
  doi          = {{10.2174/1381612828666220211151204}},
  volume       = {{28}},
  year         = {{2022}},
}