The intra- and inter-day repeatability of corneal densitometry measurements in subjects with keratoconus and in healthy controls
Gustafsson, Ingemar LU ; Bizios, Dimitrios LU
; Ivarsen, Anders
and Hjortdal, Jesper Ø
(2023)
In Scientific Reports
13.
- Abstract
The healthy cornea is transparent, however, disease can affect its structure, rendering it more or less opaque. The ability to assess the clarity of the cornea objectively could thus be of considerable interest for keratoconus patients. It has previously been suggested that densitometry can be used to diagnose early keratoconus, and that the values of densitometry variables increase with increasing disease severity, indicating that densitometry could also be used to assess progressive keratoconus. Previous studies have only assessed the repeatability of corneal densitometry measurements on the same day, which does not reflect the clinical setting in which changes are evaluated over time. We have therefore evaluated the inter-day... (More)
The healthy cornea is transparent, however, disease can affect its structure, rendering it more or less opaque. The ability to assess the clarity of the cornea objectively could thus be of considerable interest for keratoconus patients. It has previously been suggested that densitometry can be used to diagnose early keratoconus, and that the values of densitometry variables increase with increasing disease severity, indicating that densitometry could also be used to assess progressive keratoconus. Previous studies have only assessed the repeatability of corneal densitometry measurements on the same day, which does not reflect the clinical setting in which changes are evaluated over time. We have therefore evaluated the inter-day repeatability of densitometry measurements in both patients with keratoconus and healthy controls. Measurements in the middle layer of the 2-6 mm zone of the cornea showed the best repeatability. Although an objective measure of the corneal transparency could be interesting, the generally poor repeatability of densitometry measurements limits their use. The repeatability of corneal clarity measurements could be improved by using other approaches such as optical coherence tomography, but this remains to be investigated. Such improvements would allow the more widespread use of corneal densitometry in clinical practice.
(Less)
- author
- Gustafsson, Ingemar
LU
; Bizios, Dimitrios
LU
; Ivarsen, Anders
and Hjortdal, Jesper Ø
- organization
- publishing date
- 2023-04-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Keratoconus/diagnosis, Corneal Topography, Densitometry/methods, Cornea, Visual Acuity, Reproducibility of Results
- in
- Scientific Reports
- volume
- 13
- article number
- 5566
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85151788468
- pmid:37019974
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-023-32822-y
- language
- English
- LU publication?
- yes
- additional info
- © 2023. The Author(s).
- id
- 53c7598d-2278-4950-80b7-3f531c08ab48
- date added to LUP
- 2023-08-17 10:21:11
- date last changed
- 2024-04-20 00:52:35
@article{53c7598d-2278-4950-80b7-3f531c08ab48,
abstract = {{<p>The healthy cornea is transparent, however, disease can affect its structure, rendering it more or less opaque. The ability to assess the clarity of the cornea objectively could thus be of considerable interest for keratoconus patients. It has previously been suggested that densitometry can be used to diagnose early keratoconus, and that the values of densitometry variables increase with increasing disease severity, indicating that densitometry could also be used to assess progressive keratoconus. Previous studies have only assessed the repeatability of corneal densitometry measurements on the same day, which does not reflect the clinical setting in which changes are evaluated over time. We have therefore evaluated the inter-day repeatability of densitometry measurements in both patients with keratoconus and healthy controls. Measurements in the middle layer of the 2-6 mm zone of the cornea showed the best repeatability. Although an objective measure of the corneal transparency could be interesting, the generally poor repeatability of densitometry measurements limits their use. The repeatability of corneal clarity measurements could be improved by using other approaches such as optical coherence tomography, but this remains to be investigated. Such improvements would allow the more widespread use of corneal densitometry in clinical practice.</p>}},
author = {{Gustafsson, Ingemar and Bizios, Dimitrios and Ivarsen, Anders and Hjortdal, Jesper Ø}},
issn = {{2045-2322}},
keywords = {{Humans; Keratoconus/diagnosis; Corneal Topography; Densitometry/methods; Cornea; Visual Acuity; Reproducibility of Results}},
language = {{eng}},
month = {{04}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{The intra- and inter-day repeatability of corneal densitometry measurements in subjects with keratoconus and in healthy controls}},
url = {{http://dx.doi.org/10.1038/s41598-023-32822-y}},
doi = {{10.1038/s41598-023-32822-y}},
volume = {{13}},
year = {{2023}},
}