RIFM fragrance ingredient safety assessment, α-Methylbenzyl acetate, CAS Registry Number 93-92-5
(2016) In Food and Chemical Toxicology 97. p.57-68- Abstract
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Developmental toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 100 mg/kg/day. A gavage developmental toxicity study conducted in rats on a suitable read across analog resulted in aMOE of 3571 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
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https://lup.lub.lu.se/record/53cd6b77-db08-47bf-8215-56f5da28b464
- author
- publishing date
- 2016-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Reproductive and developmental toxicity, Skin sensitization
- in
- Food and Chemical Toxicology
- volume
- 97
- pages
- 12 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:26829616
- scopus:84995945117
- ISSN
- 0278-6915
- DOI
- 10.1016/j.fct.2016.01.020
- language
- English
- LU publication?
- no
- id
- 53cd6b77-db08-47bf-8215-56f5da28b464
- date added to LUP
- 2016-12-06 09:31:26
- date last changed
- 2024-06-28 20:45:29
@article{53cd6b77-db08-47bf-8215-56f5da28b464, abstract = {{<p>The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Developmental toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 100 mg/kg/day. A gavage developmental toxicity study conducted in rats on a suitable read across analog resulted in aMOE of 3571 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.</p>}}, author = {{Api, A. M. and Belsito, D. and Bhatia, S. and Bruze, M. and Calow, P. and Dagli, M. L. and Dekant, W. and Fryer, A. D. and Kromidas, L. and La Cava, S. and Lalko, J. F. and Lapczynski, A. and Liebler, D. C. and Politano, V. T. and Ritacco, G. and Salvito, D. and Schultz, T. W. and Shen, J. and Sipes, I. G. and Wall, B. and Wilcox, D. K.}}, issn = {{0278-6915}}, keywords = {{Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Reproductive and developmental toxicity; Skin sensitization}}, language = {{eng}}, month = {{11}}, pages = {{57--68}}, publisher = {{Elsevier}}, series = {{Food and Chemical Toxicology}}, title = {{RIFM fragrance ingredient safety assessment, α-Methylbenzyl acetate, CAS Registry Number 93-92-5}}, url = {{http://dx.doi.org/10.1016/j.fct.2016.01.020}}, doi = {{10.1016/j.fct.2016.01.020}}, volume = {{97}}, year = {{2016}}, }