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RIFM fragrance ingredient safety assessment, α-Methylbenzyl acetate, CAS Registry Number 93-92-5

Api, A. M. ; Belsito, D. ; Bhatia, S. ; Bruze, M. LU ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, A. D. ; Kromidas, L. and La Cava, S. , et al. (2016) In Food and Chemical Toxicology 97. p.57-68
Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Developmental toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 100 mg/kg/day. A gavage developmental toxicity study conducted in rats on a suitable read across analog resulted in aMOE of 3571 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Reproductive and developmental toxicity, Skin sensitization
in
Food and Chemical Toxicology
volume
97
pages
12 pages
publisher
Elsevier
external identifiers
  • scopus:84995945117
  • pmid:26829616
ISSN
0278-6915
DOI
10.1016/j.fct.2016.01.020
language
English
LU publication?
no
id
53cd6b77-db08-47bf-8215-56f5da28b464
date added to LUP
2016-12-06 09:31:26
date last changed
2024-06-28 20:45:29
@article{53cd6b77-db08-47bf-8215-56f5da28b464,
  abstract     = {{<p>The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Developmental toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 100 mg/kg/day. A gavage developmental toxicity study conducted in rats on a suitable read across analog resulted in aMOE of 3571 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of &gt;100 is deemed acceptable.</p>}},
  author       = {{Api, A. M. and Belsito, D. and Bhatia, S. and Bruze, M. and Calow, P. and Dagli, M. L. and Dekant, W. and Fryer, A. D. and Kromidas, L. and La Cava, S. and Lalko, J. F. and Lapczynski, A. and Liebler, D. C. and Politano, V. T. and Ritacco, G. and Salvito, D. and Schultz, T. W. and Shen, J. and Sipes, I. G. and Wall, B. and Wilcox, D. K.}},
  issn         = {{0278-6915}},
  keywords     = {{Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Reproductive and developmental toxicity; Skin sensitization}},
  language     = {{eng}},
  month        = {{11}},
  pages        = {{57--68}},
  publisher    = {{Elsevier}},
  series       = {{Food and Chemical Toxicology}},
  title        = {{RIFM fragrance ingredient safety assessment, α-Methylbenzyl acetate, CAS Registry Number 93-92-5}},
  url          = {{http://dx.doi.org/10.1016/j.fct.2016.01.020}},
  doi          = {{10.1016/j.fct.2016.01.020}},
  volume       = {{97}},
  year         = {{2016}},
}