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Decrease of the atrial fibrillatory rate, increased organization of the atrial rhythm and termination of atrial fibrillation by AZD7009

Aunes-Jansson, Maria ; Edvardsson, Nils ; Stridh, Martin LU ; Sörnmo, Leif LU ; Frison, Lars and Berggren, Anders (2013) In Journal of Electrocardiology 46(1). p.29-35
Abstract
Background: The atrial fibrillatory rate (APR), on AZD7009 as compared to placebo, was investigated as a potential biomarker for electrophysiological effect in early antiarrhythmic drug development. Methods: Patients with permanent AF received infusions of AZD7009 and placebo in an exploratory two-way, single-blind, randomized cross-over study. The ECG was continuously recorded, and following QRST cancellation the APR, its standard deviation (SD), the exponential decay and the atrial electrogram amplitude were determined as 3-min averages. Results: The mean APR rapidly decreased by 43% from baseline (394 +/- 38 to 225 +/- 61 fibrillations/min, p = 0.0003) on AZD7009, but not on placebo. The SD of the AFR and the exponential decay decreased... (More)
Background: The atrial fibrillatory rate (APR), on AZD7009 as compared to placebo, was investigated as a potential biomarker for electrophysiological effect in early antiarrhythmic drug development. Methods: Patients with permanent AF received infusions of AZD7009 and placebo in an exploratory two-way, single-blind, randomized cross-over study. The ECG was continuously recorded, and following QRST cancellation the APR, its standard deviation (SD), the exponential decay and the atrial electrogram amplitude were determined as 3-min averages. Results: The mean APR rapidly decreased by 43% from baseline (394 +/- 38 to 225 +/- 61 fibrillations/min, p = 0.0003) on AZD7009, but not on placebo. The SD of the AFR and the exponential decay decreased in parallel. In 2 of 8 patients, termination of AF occurred after the APR had decreased by 58% and 53%, respectively. Conclusions: The APR may potentially serve as a biomarker of electrophysiological effects in early evaluation of rhythm control agents. (C) 2013 Elsevier Inc. All rights reserved. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atrial fibrillatory rate, Pharmacological conversion, Atrial, fibrillation
in
Journal of Electrocardiology
volume
46
issue
1
pages
29 - 35
publisher
Elsevier
external identifiers
  • wos:000313997400010
  • scopus:84872138059
  • pmid:23219385
ISSN
1532-8430
DOI
10.1016/j.jelectrocard.2012.09.002
language
English
LU publication?
yes
id
53d006b0-0ad3-44ba-b6d2-53184aa46a59 (old id 3590875)
date added to LUP
2016-04-01 10:40:15
date last changed
2022-01-26 01:19:03
@article{53d006b0-0ad3-44ba-b6d2-53184aa46a59,
  abstract     = {{Background: The atrial fibrillatory rate (APR), on AZD7009 as compared to placebo, was investigated as a potential biomarker for electrophysiological effect in early antiarrhythmic drug development. Methods: Patients with permanent AF received infusions of AZD7009 and placebo in an exploratory two-way, single-blind, randomized cross-over study. The ECG was continuously recorded, and following QRST cancellation the APR, its standard deviation (SD), the exponential decay and the atrial electrogram amplitude were determined as 3-min averages. Results: The mean APR rapidly decreased by 43% from baseline (394 +/- 38 to 225 +/- 61 fibrillations/min, p = 0.0003) on AZD7009, but not on placebo. The SD of the AFR and the exponential decay decreased in parallel. In 2 of 8 patients, termination of AF occurred after the APR had decreased by 58% and 53%, respectively. Conclusions: The APR may potentially serve as a biomarker of electrophysiological effects in early evaluation of rhythm control agents. (C) 2013 Elsevier Inc. All rights reserved.}},
  author       = {{Aunes-Jansson, Maria and Edvardsson, Nils and Stridh, Martin and Sörnmo, Leif and Frison, Lars and Berggren, Anders}},
  issn         = {{1532-8430}},
  keywords     = {{Atrial fibrillatory rate; Pharmacological conversion; Atrial; fibrillation}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{29--35}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Electrocardiology}},
  title        = {{Decrease of the atrial fibrillatory rate, increased organization of the atrial rhythm and termination of atrial fibrillation by AZD7009}},
  url          = {{http://dx.doi.org/10.1016/j.jelectrocard.2012.09.002}},
  doi          = {{10.1016/j.jelectrocard.2012.09.002}},
  volume       = {{46}},
  year         = {{2013}},
}