Impact of transposable elements on the evolution of mammalian gene regulation.
Medstrand, Patrik LU
; van de Lagemaat, L N
; Dunn, C A
; Landry, J-R
; Svenback, Daniel
LU
and Mager, D L
(2005)
In Cytogenetic and Genome Research
110(1-4).
p.342-352
- Abstract
- Transposable elements (TEs) are present in all organisms and nearly half of the human and mouse genome is derived from ancient transpositions. This fact alone suggests that TEs have played a major role in genome organization and evolution. Studies undertaken over the last two decades or so clearly show that TEs of various kinds have played an important role in organism evolution. Here we review the impact TEs have on the evolution Of gene regulation and gene function with an emphasis on humans. Understanding the mechanisms resulting in genomic change is central to our understanding of gene regulation, genetic disease and genome evolution. Full comprehension of these biological processes is not possible without an in depth knowledge of how... (More)
- Transposable elements (TEs) are present in all organisms and nearly half of the human and mouse genome is derived from ancient transpositions. This fact alone suggests that TEs have played a major role in genome organization and evolution. Studies undertaken over the last two decades or so clearly show that TEs of various kinds have played an important role in organism evolution. Here we review the impact TEs have on the evolution Of gene regulation and gene function with an emphasis on humans. Understanding the mechanisms resulting in genomic change is central to our understanding of gene regulation, genetic disease and genome evolution. Full comprehension of these biological processes is not possible without an in depth knowledge of how TEs impact upon the genome. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/142848
- author
- Medstrand, Patrik
LU
; van de Lagemaat, L N
; Dunn, C A
; Landry, J-R
; Svenback, Daniel
LU
and Mager, D L
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cytogenetic and Genome Research
- volume
- 110
- issue
- 1-4
- pages
- 342 - 352
- publisher
- Karger
- external identifiers
-
- wos:000231064600034
- pmid:16093686
- scopus:23844534414
- pmid:16093686
- ISSN
- 1424-859X
- DOI
- 10.1159/000084966
- language
- English
- LU publication?
- yes
- id
- 53d32d2f-5483-43fe-a193-2715736a9aff (old id 142848)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16093686&dopt=Abstract
- date added to LUP
- 2016-04-01 12:30:37
- date last changed
- 2022-01-27 06:05:18
@article{53d32d2f-5483-43fe-a193-2715736a9aff,
abstract = {{Transposable elements (TEs) are present in all organisms and nearly half of the human and mouse genome is derived from ancient transpositions. This fact alone suggests that TEs have played a major role in genome organization and evolution. Studies undertaken over the last two decades or so clearly show that TEs of various kinds have played an important role in organism evolution. Here we review the impact TEs have on the evolution Of gene regulation and gene function with an emphasis on humans. Understanding the mechanisms resulting in genomic change is central to our understanding of gene regulation, genetic disease and genome evolution. Full comprehension of these biological processes is not possible without an in depth knowledge of how TEs impact upon the genome.}},
author = {{Medstrand, Patrik and van de Lagemaat, L N and Dunn, C A and Landry, J-R and Svenback, Daniel and Mager, D L}},
issn = {{1424-859X}},
language = {{eng}},
number = {{1-4}},
pages = {{342--352}},
publisher = {{Karger}},
series = {{Cytogenetic and Genome Research}},
title = {{Impact of transposable elements on the evolution of mammalian gene regulation.}},
url = {{http://dx.doi.org/10.1159/000084966}},
doi = {{10.1159/000084966}},
volume = {{110}},
year = {{2005}},
}