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TRIM28 and the control of transposable elements in the brain

Grassi, Daniela A. LU ; Jönsson, Marie E. LU ; Brattås, Per Ludvik LU and Jakobsson, Johan LU (2019) In Brain Research 1705. p.43-47
Abstract

TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. TRIM28 participates, together with the large family of Kruppel-associated box domain zinc finger proteins (KRAB-ZFP) transcription factors, in the repression of transposable elements (TE). Recent advances indicate that TRIM28-based repression of TEs occurs in the mammalian brain and may provide beneficial effects through the regulation of transcriptional networks. Here, we provide an overview of TRIM28-related functions, highlighting the role of controlling TEs in neural progenitor cells and discuss how this mechanism may have contributed to the evolution of the complex human brain. Finally, we outline future considerations for the field.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epigenetics, KRAB-ZFPs, Neurodevelopment, Transposable elements
in
Brain Research
volume
1705
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:29522722
  • pmid:29522722
  • scopus:85043498068
ISSN
0006-8993
DOI
10.1016/j.brainres.2018.02.043
language
English
LU publication?
yes
id
53d6900a-ad67-41a5-a349-5ae9eeacb6c4
date added to LUP
2018-03-27 11:13:43
date last changed
2019-05-29 02:19:39
@article{53d6900a-ad67-41a5-a349-5ae9eeacb6c4,
  abstract     = {<p>TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. TRIM28 participates, together with the large family of Kruppel-associated box domain zinc finger proteins (KRAB-ZFP) transcription factors, in the repression of transposable elements (TE). Recent advances indicate that TRIM28-based repression of TEs occurs in the mammalian brain and may provide beneficial effects through the regulation of transcriptional networks. Here, we provide an overview of TRIM28-related functions, highlighting the role of controlling TEs in neural progenitor cells and discuss how this mechanism may have contributed to the evolution of the complex human brain. Finally, we outline future considerations for the field.</p>},
  author       = {Grassi, Daniela A. and Jönsson, Marie E. and Brattås, Per Ludvik and Jakobsson, Johan},
  issn         = {0006-8993},
  language     = {eng},
  pages        = {43--47},
  publisher    = {Elsevier},
  series       = {Brain Research},
  title        = {TRIM28 and the control of transposable elements in the brain},
  url          = {http://dx.doi.org/10.1016/j.brainres.2018.02.043},
  doi          = {10.1016/j.brainres.2018.02.043},
  volume       = {1705},
  year         = {2019},
}