Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden
(2003) In Human Immunology 64(5). p.553-561- Abstract
- Major histocompatibility complex (MHC) class I chain related gene-A (MIC-A) is associated with type 1 diabetes mellitus (T1DM) in other populations. We tested the association of MIC-A gene polymorphism with T1DM in Swedish Caucasians; if it has an age-dependent association; and if the association has an effect on gender. We studied 635 T1DM patients and 503 matched controls in the age group of 0-35 years old. MIC-A5 was significantly increased in T1DM compared with controls (odds ratio [OR] =1.81, p(c) < 0.0005). Logistic regression analysis revealed MIC-A5 association was independent of HLA. MIC-A5 with DR4-DQ8 or MIC-A5 with DR3-DQ2 gave higher OR than the OR obtained with either of them alone (OR = 1.81, 7.1, and 3.6, respectively).... (More)
- Major histocompatibility complex (MHC) class I chain related gene-A (MIC-A) is associated with type 1 diabetes mellitus (T1DM) in other populations. We tested the association of MIC-A gene polymorphism with T1DM in Swedish Caucasians; if it has an age-dependent association; and if the association has an effect on gender. We studied 635 T1DM patients and 503 matched controls in the age group of 0-35 years old. MIC-A5 was significantly increased in T1DM compared with controls (odds ratio [OR] =1.81, p(c) < 0.0005). Logistic regression analysis revealed MIC-A5 association was independent of HLA. MIC-A5 with DR4-DQ8 or MIC-A5 with DR3-DQ2 gave higher OR than the OR obtained with either of them alone (OR = 1.81, 7.1, and 3.6, respectively). MIC-A5 was positively (OR = 2.48, p(c) < 0.0005) and MIC-A6 negatively associated (OR = 0.61, p(c) = 0.035) with the disease in less than or equal to 20 years of age. The negative association of MIC-A6 in young onset was confirmed by logistic regression analysis. MIC-A5 was associated with the disease in males (OR = 2.05, p(c) = 0.0005). MIC-A6 conferred protection (OR = 0.098, p(c) = 0.032) in females heterozygous for DR3/DR4. In conclusion, MIC-A5 is associated with T1DM; the association was higher in individuals less than or equal to 20 years old; and negative association of MIC-A6 was stronger in younger onset patients than in older onset patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/313066
- author
- Gupta, Manu ; Nikitina-Zake, Liene ; Zarghami, Marjan ; Landin-Olsson, Mona LU ; Kockum, Ingrid ; Lernmark, Åke LU and Sanjeevi, Carani B
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Swedish population, autoimmune disease, gender, HLA, age
- in
- Human Immunology
- volume
- 64
- issue
- 5
- pages
- 553 - 561
- publisher
- Elsevier
- external identifiers
-
- wos:000182424500009
- pmid:12691706
- scopus:0037404664
- ISSN
- 0198-8859
- DOI
- 10.1016/S0198-8859(03)00035-1
- language
- English
- LU publication?
- yes
- id
- 53f324f8-f049-454f-89c1-78fe5c1a0689 (old id 313066)
- date added to LUP
- 2016-04-01 12:19:27
- date last changed
- 2024-01-08 16:29:22
@article{53f324f8-f049-454f-89c1-78fe5c1a0689, abstract = {{Major histocompatibility complex (MHC) class I chain related gene-A (MIC-A) is associated with type 1 diabetes mellitus (T1DM) in other populations. We tested the association of MIC-A gene polymorphism with T1DM in Swedish Caucasians; if it has an age-dependent association; and if the association has an effect on gender. We studied 635 T1DM patients and 503 matched controls in the age group of 0-35 years old. MIC-A5 was significantly increased in T1DM compared with controls (odds ratio [OR] =1.81, p(c) < 0.0005). Logistic regression analysis revealed MIC-A5 association was independent of HLA. MIC-A5 with DR4-DQ8 or MIC-A5 with DR3-DQ2 gave higher OR than the OR obtained with either of them alone (OR = 1.81, 7.1, and 3.6, respectively). MIC-A5 was positively (OR = 2.48, p(c) < 0.0005) and MIC-A6 negatively associated (OR = 0.61, p(c) = 0.035) with the disease in less than or equal to 20 years of age. The negative association of MIC-A6 in young onset was confirmed by logistic regression analysis. MIC-A5 was associated with the disease in males (OR = 2.05, p(c) = 0.0005). MIC-A6 conferred protection (OR = 0.098, p(c) = 0.032) in females heterozygous for DR3/DR4. In conclusion, MIC-A5 is associated with T1DM; the association was higher in individuals less than or equal to 20 years old; and negative association of MIC-A6 was stronger in younger onset patients than in older onset patients.}}, author = {{Gupta, Manu and Nikitina-Zake, Liene and Zarghami, Marjan and Landin-Olsson, Mona and Kockum, Ingrid and Lernmark, Åke and Sanjeevi, Carani B}}, issn = {{0198-8859}}, keywords = {{Swedish population; autoimmune disease; gender; HLA; age}}, language = {{eng}}, number = {{5}}, pages = {{553--561}}, publisher = {{Elsevier}}, series = {{Human Immunology}}, title = {{Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden}}, url = {{http://dx.doi.org/10.1016/S0198-8859(03)00035-1}}, doi = {{10.1016/S0198-8859(03)00035-1}}, volume = {{64}}, year = {{2003}}, }