Advanced

Validation of EULAR primary Sjogren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)

Seror, Raphaele; Theander, Elke LU ; Brun, Johan G.; Ramos-Casals, Manel; Valim, Valeria; Doerner, Thomas; Bootsma, Hendrika; Tzioufas, Athanasios; Solans-Laque, Roser and Mandl, Thomas LU , et al. (2014) In Annals of the Rheumatic Diseases 74(5). p.859-866
Abstract
Objectives To validate the two recently developed disease activity indexes for assessment of primary Sjogren's syndrome (SS): the European League Against Rheumatism (EULAR) SS Patient Reported Index (ESSPRI) and the EULAR SS Disease Activity Index (ESSDAI). Methods A prospective international 6-month duration validation study was conducted in 15 countries. At each visit, physicians completed ESSDAI, SS disease activity index (SSDAI), Sjogren's Systemic Clinical Activity Index (SCAI) and physician global assessment (PhGA); and patients completed ESSPRI, Sicca Symptoms Inventory (SSI), Profile of Fatigue and Discomfort (PROFAD) and patient global assessment (PGA). Psychometric properties (construct validity, responsiveness and reliability)... (More)
Objectives To validate the two recently developed disease activity indexes for assessment of primary Sjogren's syndrome (SS): the European League Against Rheumatism (EULAR) SS Patient Reported Index (ESSPRI) and the EULAR SS Disease Activity Index (ESSDAI). Methods A prospective international 6-month duration validation study was conducted in 15 countries. At each visit, physicians completed ESSDAI, SS disease activity index (SSDAI), Sjogren's Systemic Clinical Activity Index (SCAI) and physician global assessment (PhGA); and patients completed ESSPRI, Sicca Symptoms Inventory (SSI), Profile of Fatigue and Discomfort (PROFAD) and patient global assessment (PGA). Psychometric properties (construct validity, responsiveness and reliability) were evaluated and compared between scores. Results Of the 395 patients included, 145 (37%) and 251 (64%) had currently active or current or past systemic manifestations, respectively. EULAR scores had higher correlation with the gold standard than other scores (ESSDAI with PhGA: r= 0.59; ESSRPI with PGA: r= 0.70). Correlations between patient and systemic scores were very low (ranging from 0.07 to 0.29). All systemic scores had similar large responsiveness in improved patients. Responsiveness of patient scores was low but was significantly higher for ESSPRI compared with SSI and PROFAD. Reliability was very good for all scores. Conclusions ESSDAI and ESSPRI had good construct validity. All scores were reliable. Systemic scores had a large sensitivity to change in patients whose disease activity improves. Patient scores had a small sensitivity to change, however, significantly better for ESSPRI. Systemic and patient scores poorly correlated, suggesting that they are 2 complementary components that should be both evaluated, but separately. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
74
issue
5
pages
859 - 866
publisher
British Medical Association
external identifiers
  • wos:000352158500017
  • scopus:84926609858
ISSN
1468-2060
DOI
10.1136/annrheumdis-2013-204615
language
English
LU publication?
yes
id
5b0351ef-a8ea-4dd7-81fc-0734ec0a2928 (old id 5403188)
date added to LUP
2015-06-01 09:25:02
date last changed
2017-11-19 03:58:18
@article{5b0351ef-a8ea-4dd7-81fc-0734ec0a2928,
  abstract     = {Objectives To validate the two recently developed disease activity indexes for assessment of primary Sjogren's syndrome (SS): the European League Against Rheumatism (EULAR) SS Patient Reported Index (ESSPRI) and the EULAR SS Disease Activity Index (ESSDAI). Methods A prospective international 6-month duration validation study was conducted in 15 countries. At each visit, physicians completed ESSDAI, SS disease activity index (SSDAI), Sjogren's Systemic Clinical Activity Index (SCAI) and physician global assessment (PhGA); and patients completed ESSPRI, Sicca Symptoms Inventory (SSI), Profile of Fatigue and Discomfort (PROFAD) and patient global assessment (PGA). Psychometric properties (construct validity, responsiveness and reliability) were evaluated and compared between scores. Results Of the 395 patients included, 145 (37%) and 251 (64%) had currently active or current or past systemic manifestations, respectively. EULAR scores had higher correlation with the gold standard than other scores (ESSDAI with PhGA: r= 0.59; ESSRPI with PGA: r= 0.70). Correlations between patient and systemic scores were very low (ranging from 0.07 to 0.29). All systemic scores had similar large responsiveness in improved patients. Responsiveness of patient scores was low but was significantly higher for ESSPRI compared with SSI and PROFAD. Reliability was very good for all scores. Conclusions ESSDAI and ESSPRI had good construct validity. All scores were reliable. Systemic scores had a large sensitivity to change in patients whose disease activity improves. Patient scores had a small sensitivity to change, however, significantly better for ESSPRI. Systemic and patient scores poorly correlated, suggesting that they are 2 complementary components that should be both evaluated, but separately.},
  author       = {Seror, Raphaele and Theander, Elke and Brun, Johan G. and Ramos-Casals, Manel and Valim, Valeria and Doerner, Thomas and Bootsma, Hendrika and Tzioufas, Athanasios and Solans-Laque, Roser and Mandl, Thomas and Gottenberg, Jacques-Eric and Hachulla, Eric and Sivils, Kathy L. and Ng, Wan-Fai and Fauchais, Anne-Laure and Bombardieri, Stefano and Valesini, Guido and Bartoloni, Elena and Saraux, Alain and Tomsic, Matija and Sumida, Takayuki and Nishiyama, Susumu and Caporali, Roberto and Kruize, Aike A. and Vollenweider, Cristina and Ravaud, Philippe and Vitali, Claudio and Mariette, Xavier and Bowman, Simon J.},
  issn         = {1468-2060},
  language     = {eng},
  number       = {5},
  pages        = {859--866},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Validation of EULAR primary Sjogren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)},
  url          = {http://dx.doi.org/10.1136/annrheumdis-2013-204615},
  volume       = {74},
  year         = {2014},
}