Advanced

Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus.

Rignell-Hydbom, Anna LU ; Rylander, Lars LU and Hagmar, Lars (2007) In Human & Experimental Toxicology 26(5). p.447-452
Abstract
Persistent organochlorine pollutants (POPs), such aspolychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in recent epidemiological studies. We have analysed 2,2',4,4',5,5' -hexachlorobiphenyl (CB-153) and p,p'-DDE in 544 serum-samples from Swedish women with a median age of 50 years. The participants were asked if they had diabetesand if so, what type of diabetes, years since diagnosis and what kind of treatment they had. Associations between exposure and T2DM were analysed by logistic regression. Moreover, trends of T2DM prevalence were... (More)
Persistent organochlorine pollutants (POPs), such aspolychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in recent epidemiological studies. We have analysed 2,2',4,4',5,5' -hexachlorobiphenyl (CB-153) and p,p'-DDE in 544 serum-samples from Swedish women with a median age of 50 years. The participants were asked if they had diabetesand if so, what type of diabetes, years since diagnosis and what kind of treatment they had. Associations between exposure and T2DM were analysed by logistic regression. Moreover, trends of T2DM prevalence were tested with Jonckheere-Terpstra' test. Sixteen of the 544 women (3%) had diabetes, of which15 were classified as T2DM. There was a significant associationwith T2DM for both CB-153 (an increase of 100ng/glipid corresponded to an odds ratio [OR] of 1. 6, 95% confidenceinterval [CI] 1. 0, 2. 7) and p,p9-DDE (OR 1. 3, 95%CI 1. 1, 1. 6). In addition, significant positive trends betweenquartiles of CB-153 and T2DM (P 5 0. 004) and p,p9-DDEand T2DM (P 5 0. 002) were observed. The study showsan association between POP serum concentrations andan increased prevalence of T2DM. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
type 2 diabetes mellitus, p, dietary exposure, p'-DDE, persistent organochlorine pollutants, PCB
in
Human & Experimental Toxicology
volume
26
issue
5
pages
447 - 452
publisher
SAGE Publications Inc.
external identifiers
  • wos:000248156000008
  • scopus:34447306617
ISSN
0960-3271
DOI
10.1177/0960327107076886
language
English
LU publication?
yes
id
a8643b8f-814d-4ebb-9ccd-92fd4f08c7aa (old id 540843)
date added to LUP
2007-12-14 11:18:56
date last changed
2017-10-29 04:12:58
@article{a8643b8f-814d-4ebb-9ccd-92fd4f08c7aa,
  abstract     = {Persistent organochlorine pollutants (POPs), such aspolychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in recent epidemiological studies. We have analysed 2,2',4,4',5,5' -hexachlorobiphenyl (CB-153) and p,p'-DDE in 544 serum-samples from Swedish women with a median age of 50 years. The participants were asked if they had diabetesand if so, what type of diabetes, years since diagnosis and what kind of treatment they had. Associations between exposure and T2DM were analysed by logistic regression. Moreover, trends of T2DM prevalence were tested with Jonckheere-Terpstra' test. Sixteen of the 544 women (3%) had diabetes, of which15 were classified as T2DM. There was a significant associationwith T2DM for both CB-153 (an increase of 100ng/glipid corresponded to an odds ratio [OR] of 1. 6, 95% confidenceinterval [CI] 1. 0, 2. 7) and p,p9-DDE (OR 1. 3, 95%CI 1. 1, 1. 6). In addition, significant positive trends betweenquartiles of CB-153 and T2DM (P 5 0. 004) and p,p9-DDEand T2DM (P 5 0. 002) were observed. The study showsan association between POP serum concentrations andan increased prevalence of T2DM.},
  author       = {Rignell-Hydbom, Anna and Rylander, Lars and Hagmar, Lars},
  issn         = {0960-3271},
  keyword      = {type 2 diabetes mellitus,p,dietary exposure,p'-DDE,persistent organochlorine pollutants,PCB},
  language     = {eng},
  number       = {5},
  pages        = {447--452},
  publisher    = {SAGE Publications Inc.},
  series       = {Human & Experimental Toxicology},
  title        = {Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus.},
  url          = {http://dx.doi.org/10.1177/0960327107076886},
  volume       = {26},
  year         = {2007},
}