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Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men.

Öhlin, Bertil LU ; Berglund, Göran LU ; Nilsson, Peter LU and Melander, Olle LU (2007) In Journal of Hypertension 25(8). p.1613-1619
Abstract
Background Job strain (high demands and low decision latitude) and the DID genotype of an I/D polymorphism in the adrenergic alpha(2B)-receptor have been associated with hypertension, respectively. We hypothesized that the I/D polymorphism interacts with external stress, such as job strain, in the development of hypertension. Methods A sample of 3045 employed men and women from the population cohort of Malmo Diet and Cancer Study, n = 28 098, with baseline data regarding work characteristics and cardiovascular risk factors, were genotyped for the adrenergic alpha(2B)-receptor I/D polymorphism. This was possible in 1302 men and 1662 women, and these individuals formed the study group. Results The age-adjusted systolic blood pressure (SBP)... (More)
Background Job strain (high demands and low decision latitude) and the DID genotype of an I/D polymorphism in the adrenergic alpha(2B)-receptor have been associated with hypertension, respectively. We hypothesized that the I/D polymorphism interacts with external stress, such as job strain, in the development of hypertension. Methods A sample of 3045 employed men and women from the population cohort of Malmo Diet and Cancer Study, n = 28 098, with baseline data regarding work characteristics and cardiovascular risk factors, were genotyped for the adrenergic alpha(2B)-receptor I/D polymorphism. This was possible in 1302 men and 1662 women, and these individuals formed the study group. Results The age-adjusted systolic blood pressure (SBP) for men with the DD polymorphism and job strain (n = 26) was 147.0 +/- 3.4 mmHg, whereas for men with the DD polymorphism but without job strain (n = 184), the SBP was 138.2 +/- 1.4 mmHg (P = 0.018). Similar findings were made regarding diastolic blood pressures (DBP) in men. Job strain and the I/D polymorphism in the adrenergic alpha(2B)-receptor gene significantly interacted in men [P = 0.008 for SBP, P = 0.03 for DBP, adjusted for age, body mass index, occupational status and nationality (Model 1)]. Increasing latitude score was inversely correlated with SBP (beta -0.17, P = 0.03, Model 1) in DD men, but not in men with the I-allele; interaction significance for genotype X latitude score, P = 0.02 for SBP (Model 1). In women, there were no significant interactions between genotype and work characteristics (P = 0.32 for SBP, and P = 0.60 for DBP). Conclusion For the first time, a significant interaction between a genetic factor and work environment, resulting in elevated blood pressures, has been described. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alpha-2 adrenergic receptor, blood pressure, genetic polymorphism, hypertension psychological stress, work
in
Journal of Hypertension
volume
25
issue
8
pages
1613 - 1619
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000248414400014
ISSN
1473-5598
language
English
LU publication?
yes
id
e4909a38-91ae-41b1-b3c8-a674375cad6b (old id 540908)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17620957&dopt=Abstract
http://www.jhypertension.com/pt/re/jhypertension/abstract.00004872-200708000-00014.htm
date added to LUP
2007-12-19 09:52:31
date last changed
2016-04-16 03:12:04
@article{e4909a38-91ae-41b1-b3c8-a674375cad6b,
  abstract     = {Background Job strain (high demands and low decision latitude) and the DID genotype of an I/D polymorphism in the adrenergic alpha(2B)-receptor have been associated with hypertension, respectively. We hypothesized that the I/D polymorphism interacts with external stress, such as job strain, in the development of hypertension. Methods A sample of 3045 employed men and women from the population cohort of Malmo Diet and Cancer Study, n = 28 098, with baseline data regarding work characteristics and cardiovascular risk factors, were genotyped for the adrenergic alpha(2B)-receptor I/D polymorphism. This was possible in 1302 men and 1662 women, and these individuals formed the study group. Results The age-adjusted systolic blood pressure (SBP) for men with the DD polymorphism and job strain (n = 26) was 147.0 +/- 3.4 mmHg, whereas for men with the DD polymorphism but without job strain (n = 184), the SBP was 138.2 +/- 1.4 mmHg (P = 0.018). Similar findings were made regarding diastolic blood pressures (DBP) in men. Job strain and the I/D polymorphism in the adrenergic alpha(2B)-receptor gene significantly interacted in men [P = 0.008 for SBP, P = 0.03 for DBP, adjusted for age, body mass index, occupational status and nationality (Model 1)]. Increasing latitude score was inversely correlated with SBP (beta -0.17, P = 0.03, Model 1) in DD men, but not in men with the I-allele; interaction significance for genotype X latitude score, P = 0.02 for SBP (Model 1). In women, there were no significant interactions between genotype and work characteristics (P = 0.32 for SBP, and P = 0.60 for DBP). Conclusion For the first time, a significant interaction between a genetic factor and work environment, resulting in elevated blood pressures, has been described.},
  author       = {Öhlin, Bertil and Berglund, Göran and Nilsson, Peter and Melander, Olle},
  issn         = {1473-5598},
  keyword      = {alpha-2 adrenergic receptor,blood pressure,genetic polymorphism,hypertension
psychological stress,work},
  language     = {eng},
  number       = {8},
  pages        = {1613--1619},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men.},
  volume       = {25},
  year         = {2007},
}