Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men.
Öhlin, Bertil LU ; Berglund, Göran LU ; Nilsson, Peter LU and Melander, Olle LU
(2007)
In Journal of Hypertension
25(8).
p.1613-1619
- Abstract
- Background Job strain (high demands and low decision latitude) and the DID genotype of an I/D polymorphism in the adrenergic alpha(2B)-receptor have been associated with hypertension, respectively. We hypothesized that the I/D polymorphism interacts with external stress, such as job strain, in the development of hypertension. Methods A sample of 3045 employed men and women from the population cohort of Malmo Diet and Cancer Study, n = 28 098, with baseline data regarding work characteristics and cardiovascular risk factors, were genotyped for the adrenergic alpha(2B)-receptor I/D polymorphism. This was possible in 1302 men and 1662 women, and these individuals formed the study group. Results The age-adjusted systolic blood pressure (SBP)... (More)
- Background Job strain (high demands and low decision latitude) and the DID genotype of an I/D polymorphism in the adrenergic alpha(2B)-receptor have been associated with hypertension, respectively. We hypothesized that the I/D polymorphism interacts with external stress, such as job strain, in the development of hypertension. Methods A sample of 3045 employed men and women from the population cohort of Malmo Diet and Cancer Study, n = 28 098, with baseline data regarding work characteristics and cardiovascular risk factors, were genotyped for the adrenergic alpha(2B)-receptor I/D polymorphism. This was possible in 1302 men and 1662 women, and these individuals formed the study group. Results The age-adjusted systolic blood pressure (SBP) for men with the DD polymorphism and job strain (n = 26) was 147.0 +/- 3.4 mmHg, whereas for men with the DD polymorphism but without job strain (n = 184), the SBP was 138.2 +/- 1.4 mmHg (P = 0.018). Similar findings were made regarding diastolic blood pressures (DBP) in men. Job strain and the I/D polymorphism in the adrenergic alpha(2B)-receptor gene significantly interacted in men [P = 0.008 for SBP, P = 0.03 for DBP, adjusted for age, body mass index, occupational status and nationality (Model 1)]. Increasing latitude score was inversely correlated with SBP (beta -0.17, P = 0.03, Model 1) in DD men, but not in men with the I-allele; interaction significance for genotype X latitude score, P = 0.02 for SBP (Model 1). In women, there were no significant interactions between genotype and work characteristics (P = 0.32 for SBP, and P = 0.60 for DBP). Conclusion For the first time, a significant interaction between a genetic factor and work environment, resulting in elevated blood pressures, has been described. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/540908
- author
- Öhlin, Bertil
LU
; Berglund, Göran
LU
; Nilsson, Peter
LU
and Melander, Olle
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- alpha-2 adrenergic receptor, blood pressure, genetic polymorphism, hypertension psychological stress, work
- in
- Journal of Hypertension
- volume
- 25
- issue
- 8
- pages
- 1613 - 1619
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000248414400014
- ISSN
- 1473-5598
- language
- English
- LU publication?
- yes
- id
- e4909a38-91ae-41b1-b3c8-a674375cad6b (old id 540908)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17620957&dopt=Abstract
- http://www.jhypertension.com/pt/re/jhypertension/abstract.00004872-200708000-00014.htm
- date added to LUP
- 2016-04-01 15:39:38
- date last changed
- 2023-04-18 19:53:38
@article{e4909a38-91ae-41b1-b3c8-a674375cad6b,
abstract = {{Background Job strain (high demands and low decision latitude) and the DID genotype of an I/D polymorphism in the adrenergic alpha(2B)-receptor have been associated with hypertension, respectively. We hypothesized that the I/D polymorphism interacts with external stress, such as job strain, in the development of hypertension. Methods A sample of 3045 employed men and women from the population cohort of Malmo Diet and Cancer Study, n = 28 098, with baseline data regarding work characteristics and cardiovascular risk factors, were genotyped for the adrenergic alpha(2B)-receptor I/D polymorphism. This was possible in 1302 men and 1662 women, and these individuals formed the study group. Results The age-adjusted systolic blood pressure (SBP) for men with the DD polymorphism and job strain (n = 26) was 147.0 +/- 3.4 mmHg, whereas for men with the DD polymorphism but without job strain (n = 184), the SBP was 138.2 +/- 1.4 mmHg (P = 0.018). Similar findings were made regarding diastolic blood pressures (DBP) in men. Job strain and the I/D polymorphism in the adrenergic alpha(2B)-receptor gene significantly interacted in men [P = 0.008 for SBP, P = 0.03 for DBP, adjusted for age, body mass index, occupational status and nationality (Model 1)]. Increasing latitude score was inversely correlated with SBP (beta -0.17, P = 0.03, Model 1) in DD men, but not in men with the I-allele; interaction significance for genotype X latitude score, P = 0.02 for SBP (Model 1). In women, there were no significant interactions between genotype and work characteristics (P = 0.32 for SBP, and P = 0.60 for DBP). Conclusion For the first time, a significant interaction between a genetic factor and work environment, resulting in elevated blood pressures, has been described.}},
author = {{Öhlin, Bertil and Berglund, Göran and Nilsson, Peter and Melander, Olle}},
issn = {{1473-5598}},
keywords = {{alpha-2 adrenergic receptor; blood pressure; genetic polymorphism; hypertension
psychological stress; work}},
language = {{eng}},
number = {{8}},
pages = {{1613--1619}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men.}},
url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17620957&dopt=Abstract}},
volume = {{25}},
year = {{2007}},
}