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Early changes in glomerular size selectivity in young adults with type 1 diabetes and retinopathy. Results from the Diabetes Incidence Study in Sweden.

Torffvit, Ole LU ; Eriksson, Jan W; Henricsson, Marianne LU ; Sundkvist, Göran LU ; Arnqvist, Hans J; Blohmé, Goran; Bolinder, Jan; Nystrom, Lennarth; Ostman, Jan and Svensson, Maria (2007) In Journal of Diabetes and its Complications 21(4). p.246-251
Abstract
Objective: To investigate the relationship between early-onset retinopathy and urinary markers of renal dysfunction. Research Design and Methods: The Diabetes Incidence Study in Sweden (DISS) aims to register all new cases of diabetes in young adults (15-34 years). In 1987-1988, 806 patients were reported and later invited to participate in a follow-up study focusing on microvascular complications after similar to 10 years of diabetes. In the present study, 149 patients with type I diabetes, completed eye examination, and urine sampling were included. Results: The patients with retinopathy (n=58, 39%) had higher HbA(1c), (P<.001) and urinary IgG2/creatinine (P<.05) and IgG2/IgG4 ratios (P<.05). Patients with maculopathy had the... (More)
Objective: To investigate the relationship between early-onset retinopathy and urinary markers of renal dysfunction. Research Design and Methods: The Diabetes Incidence Study in Sweden (DISS) aims to register all new cases of diabetes in young adults (15-34 years). In 1987-1988, 806 patients were reported and later invited to participate in a follow-up study focusing on microvascular complications after similar to 10 years of diabetes. In the present study, 149 patients with type I diabetes, completed eye examination, and urine sampling were included. Results: The patients with retinopathy (n=58, 39%) had higher HbA(1c), (P<.001) and urinary IgG2/creatinine (P<.05) and IgG2/IgG4 ratios (P<.05). Patients with maculopathy had the highest levels. No significant differences in urinary albumin/creatinine, glycosaminoglycans (GAGs)/creatinine, Tamm-Horsfall protein (THP)/creatinine, and IgG4/creatinine ratios were found. Women had higher urinary albumin/ creatinine (P<.01) and urinary IgG2/creatinine ratios (P<.01) than men. Conclusions: Young adults with type I diabetes and early-onset retinopathy had higher IgG2/creatinine and IgG2/IgG4 ratios than patients without retinopathy indicating that retinopathy is associated with a change in glomerular size selectivity. This was found in association with normal urinary albumin and THP excretion and may be suspected to reflect early general vascular changes. (C) 2007 Elsevier Inc. All rights reserved. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
IgG2 and IgG4, immurroglobulin, glycosaminoglycans, size selectivity, Tamm-Horsfall protein, transforming, glomerular, growth factor (TGF beta 1), diabetic retinopathy
in
Journal of Diabetes and its Complications
volume
21
issue
4
pages
246 - 251
publisher
Elsevier
external identifiers
  • wos:000248166100007
  • scopus:34347260646
ISSN
1873-460X
DOI
10.1016/j.jdiacomp.2006.01.002
language
English
LU publication?
yes
id
13551d1d-b93f-4ea0-9dec-094d88c754ce (old id 540961)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17616355&dopt=Abstract
date added to LUP
2008-01-03 10:53:07
date last changed
2017-09-24 04:26:17
@article{13551d1d-b93f-4ea0-9dec-094d88c754ce,
  abstract     = {Objective: To investigate the relationship between early-onset retinopathy and urinary markers of renal dysfunction. Research Design and Methods: The Diabetes Incidence Study in Sweden (DISS) aims to register all new cases of diabetes in young adults (15-34 years). In 1987-1988, 806 patients were reported and later invited to participate in a follow-up study focusing on microvascular complications after similar to 10 years of diabetes. In the present study, 149 patients with type I diabetes, completed eye examination, and urine sampling were included. Results: The patients with retinopathy (n=58, 39%) had higher HbA(1c), (P&lt;.001) and urinary IgG2/creatinine (P&lt;.05) and IgG2/IgG4 ratios (P&lt;.05). Patients with maculopathy had the highest levels. No significant differences in urinary albumin/creatinine, glycosaminoglycans (GAGs)/creatinine, Tamm-Horsfall protein (THP)/creatinine, and IgG4/creatinine ratios were found. Women had higher urinary albumin/ creatinine (P&lt;.01) and urinary IgG2/creatinine ratios (P&lt;.01) than men. Conclusions: Young adults with type I diabetes and early-onset retinopathy had higher IgG2/creatinine and IgG2/IgG4 ratios than patients without retinopathy indicating that retinopathy is associated with a change in glomerular size selectivity. This was found in association with normal urinary albumin and THP excretion and may be suspected to reflect early general vascular changes. (C) 2007 Elsevier Inc. All rights reserved.},
  author       = {Torffvit, Ole and Eriksson, Jan W and Henricsson, Marianne and Sundkvist, Göran and Arnqvist, Hans J and Blohmé, Goran and Bolinder, Jan and Nystrom, Lennarth and Ostman, Jan and Svensson, Maria},
  issn         = {1873-460X},
  keyword      = {IgG2 and IgG4,immurroglobulin,glycosaminoglycans,size selectivity,Tamm-Horsfall protein,transforming,glomerular,growth factor (TGF beta 1),diabetic retinopathy},
  language     = {eng},
  number       = {4},
  pages        = {246--251},
  publisher    = {Elsevier},
  series       = {Journal of Diabetes and its Complications},
  title        = {Early changes in glomerular size selectivity in young adults with type 1 diabetes and retinopathy. Results from the Diabetes Incidence Study in Sweden.},
  url          = {http://dx.doi.org/10.1016/j.jdiacomp.2006.01.002},
  volume       = {21},
  year         = {2007},
}