Silvanus Thompson Memorial Lecture Molecular imaging using hyperpolarized C-13
(2003) In British Journal of Radiology 76(Spec No 2). p.118-127- Abstract
- MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhancement enables imaging of nuclei other than protons, e.g. C-13 and N-15, and their molecular distribution in vivo can be visualized in a clinically relevant time window. This article reviews different hyperpolarization techniques and some of the many application areas. As an example, experiments are presented where hyperpolarized C-13 nuclei have been injected into rabbits, followed by rapid C-13 MRI with high spatial resolution (scan time <1... (More)
- MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhancement enables imaging of nuclei other than protons, e.g. C-13 and N-15, and their molecular distribution in vivo can be visualized in a clinically relevant time window. This article reviews different hyperpolarization techniques and some of the many application areas. As an example, experiments are presented where hyperpolarized C-13 nuclei have been injected into rabbits, followed by rapid C-13 MRI with high spatial resolution (scan time <1 s and 1.0 mm in-plane resolution). The high degree of polarization thus enabled mapping of the molecular distribution within various organs, a few seconds after injection. The hyperpolarized C-13 MRI technique allows a selective identification of the molecules that give rise to the MR signal, offering direct molecular imaging. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/897944
- author
- Golman, Klaes LU ; Olsson, Lars E LU ; Axelsson, O ; Månsson, Sven LU ; Karlsson, M and Petersson, J S LU
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Carbon Isotopes, Humans, Lung Diseases, Magnetic Resonance Imaging, Male, Models, Chemical, Rabbits, Thermodynamics
- in
- British Journal of Radiology
- volume
- 76
- issue
- Spec No 2
- pages
- 118 - 127
- publisher
- British Institute of Radiology
- external identifiers
-
- wos:000225157000004
- scopus:8844271662
- pmid:15572334
- ISSN
- 1748-880X
- DOI
- 10.1259/bjr/26631666
- language
- English
- LU publication?
- no
- id
- 541dd130-9ec7-4899-aba2-c7c45cc360a8 (old id 897944)
- alternative location
- http://bjr.birjournals.org/cgi/content/abstract/76/suppl_2/S118
- date added to LUP
- 2016-04-01 16:42:21
- date last changed
- 2022-03-07 07:47:32
@article{541dd130-9ec7-4899-aba2-c7c45cc360a8, abstract = {{MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhancement enables imaging of nuclei other than protons, e.g. C-13 and N-15, and their molecular distribution in vivo can be visualized in a clinically relevant time window. This article reviews different hyperpolarization techniques and some of the many application areas. As an example, experiments are presented where hyperpolarized C-13 nuclei have been injected into rabbits, followed by rapid C-13 MRI with high spatial resolution (scan time <1 s and 1.0 mm in-plane resolution). The high degree of polarization thus enabled mapping of the molecular distribution within various organs, a few seconds after injection. The hyperpolarized C-13 MRI technique allows a selective identification of the molecules that give rise to the MR signal, offering direct molecular imaging.}}, author = {{Golman, Klaes and Olsson, Lars E and Axelsson, O and Månsson, Sven and Karlsson, M and Petersson, J S}}, issn = {{1748-880X}}, keywords = {{Animals; Carbon Isotopes; Humans; Lung Diseases; Magnetic Resonance Imaging; Male; Models, Chemical; Rabbits; Thermodynamics}}, language = {{eng}}, number = {{Spec No 2}}, pages = {{118--127}}, publisher = {{British Institute of Radiology}}, series = {{British Journal of Radiology}}, title = {{Silvanus Thompson Memorial Lecture Molecular imaging using hyperpolarized C-13}}, url = {{http://dx.doi.org/10.1259/bjr/26631666}}, doi = {{10.1259/bjr/26631666}}, volume = {{76}}, year = {{2003}}, }