A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes
(2016) In Scientific Reports 6.- Abstract
The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxidation. Strikingly, RoxP is crucial for the survival of P. acnes in oxic conditions and for skin colonization of P. acnes ex vivo. Taken together, our study strongly suggests that RoxP facilitates P. acnes' survival on human skin, and is an... (More)
The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxidation. Strikingly, RoxP is crucial for the survival of P. acnes in oxic conditions and for skin colonization of P. acnes ex vivo. Taken together, our study strongly suggests that RoxP facilitates P. acnes' survival on human skin, and is an important beneficial factor for the host-commensal interaction. Thus, RoxP is the first described skin microbiota-derived mutualistic factor that potentially can be exploited for human skin protection.
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- author
- Allhorn, Maria LU ; Arve, Sabine LU ; Brüggemann, Holger and Lood, Rolf LU
- organization
- publishing date
- 2016-11-02
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 6
- article number
- 36412
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:27805044
- wos:000386766600001
- scopus:84994378274
- ISSN
- 2045-2322
- DOI
- 10.1038/srep36412
- project
- RoxP - en potent gynnsam antioxidant producerad av hudbakterien Propionibacterium acnes
- language
- English
- LU publication?
- yes
- id
- 5427e15a-1c74-4370-b1fa-3702006e1c94
- date added to LUP
- 2016-12-01 14:14:09
- date last changed
- 2024-08-24 01:58:34
@article{5427e15a-1c74-4370-b1fa-3702006e1c94, abstract = {{<p>The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxidation. Strikingly, RoxP is crucial for the survival of P. acnes in oxic conditions and for skin colonization of P. acnes ex vivo. Taken together, our study strongly suggests that RoxP facilitates P. acnes' survival on human skin, and is an important beneficial factor for the host-commensal interaction. Thus, RoxP is the first described skin microbiota-derived mutualistic factor that potentially can be exploited for human skin protection.</p>}}, author = {{Allhorn, Maria and Arve, Sabine and Brüggemann, Holger and Lood, Rolf}}, issn = {{2045-2322}}, language = {{eng}}, month = {{11}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes}}, url = {{http://dx.doi.org/10.1038/srep36412}}, doi = {{10.1038/srep36412}}, volume = {{6}}, year = {{2016}}, }