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A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes

Allhorn, Maria LU ; Arve, Sabine LU ; Brüggemann, Holger and Lood, Rolf LU (2016) In Scientific Reports 6.
Abstract

The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxidation. Strikingly, RoxP is crucial for the survival of P. acnes in oxic conditions and for skin colonization of P. acnes ex vivo. Taken together, our study strongly suggests that RoxP facilitates P. acnes' survival on human skin, and is an... (More)

The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxidation. Strikingly, RoxP is crucial for the survival of P. acnes in oxic conditions and for skin colonization of P. acnes ex vivo. Taken together, our study strongly suggests that RoxP facilitates P. acnes' survival on human skin, and is an important beneficial factor for the host-commensal interaction. Thus, RoxP is the first described skin microbiota-derived mutualistic factor that potentially can be exploited for human skin protection.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
6
publisher
Nature Publishing Group
external identifiers
  • scopus:84994378274
  • wos:000386766600001
ISSN
2045-2322
DOI
10.1038/srep36412
language
English
LU publication?
yes
id
5427e15a-1c74-4370-b1fa-3702006e1c94
date added to LUP
2016-12-01 14:14:09
date last changed
2017-07-09 04:55:31
@article{5427e15a-1c74-4370-b1fa-3702006e1c94,
  abstract     = {<p>The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxidation. Strikingly, RoxP is crucial for the survival of P. acnes in oxic conditions and for skin colonization of P. acnes ex vivo. Taken together, our study strongly suggests that RoxP facilitates P. acnes' survival on human skin, and is an important beneficial factor for the host-commensal interaction. Thus, RoxP is the first described skin microbiota-derived mutualistic factor that potentially can be exploited for human skin protection.</p>},
  articleno    = {36412},
  author       = {Allhorn, Maria and Arve, Sabine and Brüggemann, Holger and Lood, Rolf},
  issn         = {2045-2322},
  language     = {eng},
  month        = {11},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes},
  url          = {http://dx.doi.org/10.1038/srep36412},
  volume       = {6},
  year         = {2016},
}