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Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae).

Kohli, Gurjeet S; John, Uwe; Figueroa, Rosa LU ; Rhodes, Lesley L; Harwood, D Tim; Groth, Marco; Bolch, Christopher J S and Murray, Shauna A (2015) In BMC Genomics 16.
Abstract
Marine microbial protists, in particular, dinoflagellates, produce polyketide toxins with ecosystem-wide and human health impacts. Species of Gambierdiscus produce the polyether ladder compounds ciguatoxins and maitotoxins, which can lead to ciguatera fish poisoning, a serious human illness associated with reef fish consumption. Genes associated with the biosynthesis of polyether ladder compounds are yet to be elucidated, however, stable isotope feeding studies of such compounds consistently support their polyketide origin indicating that polyketide synthases are involved in their biosynthesis.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Genomics
volume
16
publisher
BioMed Central
external identifiers
  • pmid:26016672
  • wos:000355146100002
  • scopus:84938961854
ISSN
1471-2164
DOI
10.1186/s12864-015-1625-y
language
English
LU publication?
yes
id
0c3802a8-25b2-4b47-ae9f-ea487f1a1f52 (old id 5442101)
date added to LUP
2015-06-23 14:46:55
date last changed
2017-07-30 04:15:16
@article{0c3802a8-25b2-4b47-ae9f-ea487f1a1f52,
  abstract     = {Marine microbial protists, in particular, dinoflagellates, produce polyketide toxins with ecosystem-wide and human health impacts. Species of Gambierdiscus produce the polyether ladder compounds ciguatoxins and maitotoxins, which can lead to ciguatera fish poisoning, a serious human illness associated with reef fish consumption. Genes associated with the biosynthesis of polyether ladder compounds are yet to be elucidated, however, stable isotope feeding studies of such compounds consistently support their polyketide origin indicating that polyketide synthases are involved in their biosynthesis.},
  articleno    = {410},
  author       = {Kohli, Gurjeet S and John, Uwe and Figueroa, Rosa and Rhodes, Lesley L and Harwood, D Tim and Groth, Marco and Bolch, Christopher J S and Murray, Shauna A},
  issn         = {1471-2164},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Genomics},
  title        = {Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae).},
  url          = {http://dx.doi.org/10.1186/s12864-015-1625-y},
  volume       = {16},
  year         = {2015},
}