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The emerging complexity of gene fusions in cancer.

Mertens, Fredrik LU ; Johansson, Bertil LU ; Fioretos, Thoas LU and Mitelman, Felix LU (2015) In Nature Reviews. Cancer 15(6). p.371-381
Abstract
Structural chromosome rearrangements may result in the exchange of coding or regulatory DNA sequences between genes. Many such gene fusions are strong driver mutations in neoplasia and have provided fundamental insights into the disease mechanisms that are involved in tumorigenesis. The close association between the type of gene fusion and the tumour phenotype makes gene fusions ideal for diagnostic purposes, enabling the subclassification of otherwise seemingly identical disease entities. In addition, many gene fusions add important information for risk stratification, and increasing numbers of chimeric proteins encoded by the gene fusions serve as specific targets for treatment, resulting in dramatically improved patient outcomes. In... (More)
Structural chromosome rearrangements may result in the exchange of coding or regulatory DNA sequences between genes. Many such gene fusions are strong driver mutations in neoplasia and have provided fundamental insights into the disease mechanisms that are involved in tumorigenesis. The close association between the type of gene fusion and the tumour phenotype makes gene fusions ideal for diagnostic purposes, enabling the subclassification of otherwise seemingly identical disease entities. In addition, many gene fusions add important information for risk stratification, and increasing numbers of chimeric proteins encoded by the gene fusions serve as specific targets for treatment, resulting in dramatically improved patient outcomes. In this Timeline article, we describe the spectrum of gene fusions in cancer and how the methods to identify them have evolved, and also discuss conceptual implications of current, sequencing-based approaches for detection. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews. Cancer
volume
15
issue
6
pages
371 - 381
publisher
Nature Publishing Group
external identifiers
  • pmid:25998716
  • wos:000354962600010
  • scopus:84929858006
ISSN
1474-1768
DOI
10.1038/nrc3947
language
English
LU publication?
yes
id
32ce9f90-426a-4f4d-aaf7-ffae01f4e979 (old id 5442683)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25998716?dopt=Abstract
date added to LUP
2015-06-05 12:07:12
date last changed
2017-11-19 03:11:13
@article{32ce9f90-426a-4f4d-aaf7-ffae01f4e979,
  abstract     = {Structural chromosome rearrangements may result in the exchange of coding or regulatory DNA sequences between genes. Many such gene fusions are strong driver mutations in neoplasia and have provided fundamental insights into the disease mechanisms that are involved in tumorigenesis. The close association between the type of gene fusion and the tumour phenotype makes gene fusions ideal for diagnostic purposes, enabling the subclassification of otherwise seemingly identical disease entities. In addition, many gene fusions add important information for risk stratification, and increasing numbers of chimeric proteins encoded by the gene fusions serve as specific targets for treatment, resulting in dramatically improved patient outcomes. In this Timeline article, we describe the spectrum of gene fusions in cancer and how the methods to identify them have evolved, and also discuss conceptual implications of current, sequencing-based approaches for detection.},
  author       = {Mertens, Fredrik and Johansson, Bertil and Fioretos, Thoas and Mitelman, Felix},
  issn         = {1474-1768},
  language     = {eng},
  number       = {6},
  pages        = {371--381},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews. Cancer},
  title        = {The emerging complexity of gene fusions in cancer.},
  url          = {http://dx.doi.org/10.1038/nrc3947},
  volume       = {15},
  year         = {2015},
}