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The Frontotemporal Dementias.

Landqvist, Maria LU (2015) In Psychiatric Clinics of North America 38(2). p.193-193
Abstract
Frontotemporal dementia (FTD) is a heterogeneous group of hereditary and sporadic neurodegenerative disorders affecting frontotemporal areas. FTD, a leading cause of young-onset dementia, is often initially mistaken for primary psychiatric disorders. Based on early and predominant symptoms, different clinical syndromes can be distinguished: the behavioral variant and 2 variants of progressive aphasia; semantic dementia and progressive nonfluent aphasia. Neuropathological classification is based on protein accumulation in the brain. Pathogenic mutations in different genes have been identified. Specific pharmacological treatment is the main research goal. Meanwhile the management must focus on early correct diagnosis, symptom alleviation,... (More)
Frontotemporal dementia (FTD) is a heterogeneous group of hereditary and sporadic neurodegenerative disorders affecting frontotemporal areas. FTD, a leading cause of young-onset dementia, is often initially mistaken for primary psychiatric disorders. Based on early and predominant symptoms, different clinical syndromes can be distinguished: the behavioral variant and 2 variants of progressive aphasia; semantic dementia and progressive nonfluent aphasia. Neuropathological classification is based on protein accumulation in the brain. Pathogenic mutations in different genes have been identified. Specific pharmacological treatment is the main research goal. Meanwhile the management must focus on early correct diagnosis, symptom alleviation, caregiver support and educational interventions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Psychiatric Clinics of North America
volume
38
issue
2
pages
193 - 193
publisher
Elsevier
external identifiers
  • pmid:25998110
  • wos:000356634700002
  • scopus:84929656224
ISSN
1558-3147
DOI
10.1016/j.psc.2015.02.001
language
English
LU publication?
yes
id
0a596652-9912-4a6c-809e-c61dd148d7dc (old id 5442690)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25998110?dopt=Abstract
date added to LUP
2015-06-05 11:55:40
date last changed
2017-05-28 03:14:56
@article{0a596652-9912-4a6c-809e-c61dd148d7dc,
  abstract     = {Frontotemporal dementia (FTD) is a heterogeneous group of hereditary and sporadic neurodegenerative disorders affecting frontotemporal areas. FTD, a leading cause of young-onset dementia, is often initially mistaken for primary psychiatric disorders. Based on early and predominant symptoms, different clinical syndromes can be distinguished: the behavioral variant and 2 variants of progressive aphasia; semantic dementia and progressive nonfluent aphasia. Neuropathological classification is based on protein accumulation in the brain. Pathogenic mutations in different genes have been identified. Specific pharmacological treatment is the main research goal. Meanwhile the management must focus on early correct diagnosis, symptom alleviation, caregiver support and educational interventions.},
  author       = {Landqvist, Maria},
  issn         = {1558-3147},
  language     = {eng},
  number       = {2},
  pages        = {193--193},
  publisher    = {Elsevier},
  series       = {Psychiatric Clinics of North America},
  title        = {The Frontotemporal Dementias.},
  url          = {http://dx.doi.org/10.1016/j.psc.2015.02.001},
  volume       = {38},
  year         = {2015},
}