Arterial Stiffness and Peripheral and Central Blood Pressure in Patients With Sickle Cell Disease.
(2015) In The Journal of Clinical Hypertension 17(9). p.726-731- Abstract
- Blood pressure (BP) in patients with sickle cell disease (SCD) has been reported to be lower than in persons in the general population. Data on arterial stiffness, which is an important risk factor for the progression of BP, are inconclusive for this patient population. Forty-five adult patients with SCD and 40 controls matched for sex, age, and body mass index were studied. Brachial systolic BP (SBP) and diastolic BP (DBP) were significantly lower in the patient group (SBP 115.1±13.8 mm Hg vs 121.9±11.3 mm Hg and DBP 68.5±8.0 mm Hg vs 80.6±9.1 mm Hg, P<.05, respectively). Augmentation index (AIx), however, was significantly higher in SCD patients compared with healthy controls (24.9±9.6 for patients vs 12.4±10.8 for controls,... (More)
- Blood pressure (BP) in patients with sickle cell disease (SCD) has been reported to be lower than in persons in the general population. Data on arterial stiffness, which is an important risk factor for the progression of BP, are inconclusive for this patient population. Forty-five adult patients with SCD and 40 controls matched for sex, age, and body mass index were studied. Brachial systolic BP (SBP) and diastolic BP (DBP) were significantly lower in the patient group (SBP 115.1±13.8 mm Hg vs 121.9±11.3 mm Hg and DBP 68.5±8.0 mm Hg vs 80.6±9.1 mm Hg, P<.05, respectively). Augmentation index (AIx), however, was significantly higher in SCD patients compared with healthy controls (24.9±9.6 for patients vs 12.4±10.8 for controls, P<.001), while carotid femoral pulse wave velocity was comparable between the two groups. The study shows that mechanisms other than arterial elasticity are involved in the low BP phenotype of patients with SCD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5448579
- author
- Pikilidou, Maria ; Yavropoulou, Maria ; Antoniou, Maria ; Papakonstantinou, Eleftherios ; Pantelidou, Despoina ; Chalkia, Panagiota ; Nilsson, Peter LU ; Yovos, John and Zebekakis, Pantelis
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of Clinical Hypertension
- volume
- 17
- issue
- 9
- pages
- 726 - 731
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:25991400
- wos:000360767100015
- scopus:84940899854
- pmid:25991400
- ISSN
- 1751-7176
- DOI
- 10.1111/jch.12572
- language
- English
- LU publication?
- yes
- id
- b14e6483-e816-439b-aa83-990e51e89259 (old id 5448579)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25991400?dopt=Abstract
- date added to LUP
- 2016-04-01 09:55:44
- date last changed
- 2022-04-12 00:13:04
@article{b14e6483-e816-439b-aa83-990e51e89259, abstract = {{Blood pressure (BP) in patients with sickle cell disease (SCD) has been reported to be lower than in persons in the general population. Data on arterial stiffness, which is an important risk factor for the progression of BP, are inconclusive for this patient population. Forty-five adult patients with SCD and 40 controls matched for sex, age, and body mass index were studied. Brachial systolic BP (SBP) and diastolic BP (DBP) were significantly lower in the patient group (SBP 115.1±13.8 mm Hg vs 121.9±11.3 mm Hg and DBP 68.5±8.0 mm Hg vs 80.6±9.1 mm Hg, P<.05, respectively). Augmentation index (AIx), however, was significantly higher in SCD patients compared with healthy controls (24.9±9.6 for patients vs 12.4±10.8 for controls, P<.001), while carotid femoral pulse wave velocity was comparable between the two groups. The study shows that mechanisms other than arterial elasticity are involved in the low BP phenotype of patients with SCD.}}, author = {{Pikilidou, Maria and Yavropoulou, Maria and Antoniou, Maria and Papakonstantinou, Eleftherios and Pantelidou, Despoina and Chalkia, Panagiota and Nilsson, Peter and Yovos, John and Zebekakis, Pantelis}}, issn = {{1751-7176}}, language = {{eng}}, number = {{9}}, pages = {{726--731}}, publisher = {{Wiley-Blackwell}}, series = {{The Journal of Clinical Hypertension}}, title = {{Arterial Stiffness and Peripheral and Central Blood Pressure in Patients With Sickle Cell Disease.}}, url = {{http://dx.doi.org/10.1111/jch.12572}}, doi = {{10.1111/jch.12572}}, volume = {{17}}, year = {{2015}}, }