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Arterial Stiffness and Peripheral and Central Blood Pressure in Patients With Sickle Cell Disease.

Pikilidou, Maria; Yavropoulou, Maria; Antoniou, Maria; Papakonstantinou, Eleftherios; Pantelidou, Despoina; Chalkia, Panagiota; Nilsson, Peter LU ; Yovos, John and Zebekakis, Pantelis (2015) In The Journal of Clinical Hypertension 17(9). p.726-731
Abstract
Blood pressure (BP) in patients with sickle cell disease (SCD) has been reported to be lower than in persons in the general population. Data on arterial stiffness, which is an important risk factor for the progression of BP, are inconclusive for this patient population. Forty-five adult patients with SCD and 40 controls matched for sex, age, and body mass index were studied. Brachial systolic BP (SBP) and diastolic BP (DBP) were significantly lower in the patient group (SBP 115.1±13.8 mm Hg vs 121.9±11.3 mm Hg and DBP 68.5±8.0 mm Hg vs 80.6±9.1 mm Hg, P<.05, respectively). Augmentation index (AIx), however, was significantly higher in SCD patients compared with healthy controls (24.9±9.6 for patients vs 12.4±10.8 for controls,... (More)
Blood pressure (BP) in patients with sickle cell disease (SCD) has been reported to be lower than in persons in the general population. Data on arterial stiffness, which is an important risk factor for the progression of BP, are inconclusive for this patient population. Forty-five adult patients with SCD and 40 controls matched for sex, age, and body mass index were studied. Brachial systolic BP (SBP) and diastolic BP (DBP) were significantly lower in the patient group (SBP 115.1±13.8 mm Hg vs 121.9±11.3 mm Hg and DBP 68.5±8.0 mm Hg vs 80.6±9.1 mm Hg, P<.05, respectively). Augmentation index (AIx), however, was significantly higher in SCD patients compared with healthy controls (24.9±9.6 for patients vs 12.4±10.8 for controls, P<.001), while carotid femoral pulse wave velocity was comparable between the two groups. The study shows that mechanisms other than arterial elasticity are involved in the low BP phenotype of patients with SCD. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
The Journal of Clinical Hypertension
volume
17
issue
9
pages
726 - 731
publisher
Wiley-Blackwell
external identifiers
  • pmid:25991400
  • wos:000360767100015
  • scopus:84940899854
ISSN
1751-7176
DOI
10.1111/jch.12572
language
English
LU publication?
yes
id
b14e6483-e816-439b-aa83-990e51e89259 (old id 5448579)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25991400?dopt=Abstract
date added to LUP
2015-06-05 00:27:52
date last changed
2017-01-01 03:07:11
@article{b14e6483-e816-439b-aa83-990e51e89259,
  abstract     = {Blood pressure (BP) in patients with sickle cell disease (SCD) has been reported to be lower than in persons in the general population. Data on arterial stiffness, which is an important risk factor for the progression of BP, are inconclusive for this patient population. Forty-five adult patients with SCD and 40 controls matched for sex, age, and body mass index were studied. Brachial systolic BP (SBP) and diastolic BP (DBP) were significantly lower in the patient group (SBP 115.1±13.8 mm Hg vs 121.9±11.3 mm Hg and DBP 68.5±8.0 mm Hg vs 80.6±9.1 mm Hg, P&lt;.05, respectively). Augmentation index (AIx), however, was significantly higher in SCD patients compared with healthy controls (24.9±9.6 for patients vs 12.4±10.8 for controls, P&lt;.001), while carotid femoral pulse wave velocity was comparable between the two groups. The study shows that mechanisms other than arterial elasticity are involved in the low BP phenotype of patients with SCD.},
  author       = {Pikilidou, Maria and Yavropoulou, Maria and Antoniou, Maria and Papakonstantinou, Eleftherios and Pantelidou, Despoina and Chalkia, Panagiota and Nilsson, Peter and Yovos, John and Zebekakis, Pantelis},
  issn         = {1751-7176},
  language     = {eng},
  number       = {9},
  pages        = {726--731},
  publisher    = {Wiley-Blackwell},
  series       = {The Journal of Clinical Hypertension},
  title        = {Arterial Stiffness and Peripheral and Central Blood Pressure in Patients With Sickle Cell Disease.},
  url          = {http://dx.doi.org/10.1111/jch.12572},
  volume       = {17},
  year         = {2015},
}