Malignant hyperthermia, a Scandinavian update.
(2015) In Acta Anaesthesiologica Scandinavica 59(8). p.951-961- Abstract
- Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5448644
- author
- Broman, Marcus Ewert LU ; Islander, Gunilla LU and Müller, C R
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 59
- issue
- 8
- pages
- 951 - 961
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:25989378
- wos:000359421100001
- scopus:84938749461
- pmid:25989378
- ISSN
- 0001-5172
- DOI
- 10.1111/aas.12541
- language
- English
- LU publication?
- yes
- id
- 641e011f-ae69-4bf8-9e49-0d46950e1b72 (old id 5448644)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25989378?dopt=Abstract
- date added to LUP
- 2016-04-01 09:51:18
- date last changed
- 2022-04-11 23:34:04
@article{641e011f-ae69-4bf8-9e49-0d46950e1b72, abstract = {{Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.}}, author = {{Broman, Marcus Ewert and Islander, Gunilla and Müller, C R}}, issn = {{0001-5172}}, language = {{eng}}, number = {{8}}, pages = {{951--961}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Anaesthesiologica Scandinavica}}, title = {{Malignant hyperthermia, a Scandinavian update.}}, url = {{http://dx.doi.org/10.1111/aas.12541}}, doi = {{10.1111/aas.12541}}, volume = {{59}}, year = {{2015}}, }