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Malignant hyperthermia, a Scandinavian update.

Broman, Marcus Ewert LU ; Islander, Gunilla LU and Müller, C R (2015) In Acta Anaesthesiologica Scandinavica 59(8). p.951-961
Abstract
Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Anaesthesiologica Scandinavica
volume
59
issue
8
pages
951 - 961
publisher
Wiley-Blackwell
external identifiers
  • pmid:25989378
  • wos:000359421100001
  • scopus:84938749461
ISSN
0001-5172
DOI
10.1111/aas.12541
language
English
LU publication?
yes
id
641e011f-ae69-4bf8-9e49-0d46950e1b72 (old id 5448644)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25989378?dopt=Abstract
date added to LUP
2015-06-05 00:22:52
date last changed
2017-09-24 03:01:21
@article{641e011f-ae69-4bf8-9e49-0d46950e1b72,
  abstract     = {Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.},
  author       = {Broman, Marcus Ewert and Islander, Gunilla and Müller, C R},
  issn         = {0001-5172},
  language     = {eng},
  number       = {8},
  pages        = {951--961},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Malignant hyperthermia, a Scandinavian update.},
  url          = {http://dx.doi.org/10.1111/aas.12541},
  volume       = {59},
  year         = {2015},
}