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Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: Possible interaction with genes involved in 20-HETE and EETs metabolism.

Tagetti, Angela; Ericson, Ulrika LU ; Montagnana, Martina LU ; Danese, Elisa; Almgren, Peter LU ; Nilsson, Peter LU ; Engström, Gunnar LU ; Hedblad, Bo LU ; Minuz, Pietro and Orho-Melander, Marju LU , et al. (2015) In Prostaglandins & other Lipid Mediators 120(May 16). p.126-133
Abstract
A high intake of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been associated with reduced levels of blood pressure (BP). Their antihypertensive action may be due to the reduction of the ω-6/ω-3 ratio and the resulting competitive effect of ω-3 as compared to arachidonic acid (an ω-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators. Some functional polymorphisms (SNPs), in genes which encode for the same enzymes, were associated with hypertension and ischemic stroke in the Malmö Diet and Cancer (MDC), a Swedish urban-based longitudinal study. The aim of this study was to evaluate the effect of the intake of different types of PUFAs on BP change over time (Δ-BP; mean... (More)
A high intake of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been associated with reduced levels of blood pressure (BP). Their antihypertensive action may be due to the reduction of the ω-6/ω-3 ratio and the resulting competitive effect of ω-3 as compared to arachidonic acid (an ω-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators. Some functional polymorphisms (SNPs), in genes which encode for the same enzymes, were associated with hypertension and ischemic stroke in the Malmö Diet and Cancer (MDC), a Swedish urban-based longitudinal study. The aim of this study was to evaluate the effect of the intake of different types of PUFAs on BP change over time (Δ-BP; mean follow-up 16.6±1.5 years; n=3.550 with complete phenotypic data), also considering the interaction with SNPs in genes involved in their metabolism via CYP450. (Less)
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Contribution to journal
publication status
published
subject
in
Prostaglandins & other Lipid Mediators
volume
120
issue
May 16
pages
126 - 133
publisher
Elsevier
external identifiers
  • pmid:25986600
  • wos:000362142700016
  • scopus:84941803706
ISSN
1098-8823
DOI
10.1016/j.prostaglandins.2015.05.003
language
English
LU publication?
yes
id
1c2bf4ba-e840-4bc5-bd83-54b7939edb91 (old id 5448917)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25986600?dopt=Abstract
date added to LUP
2015-06-04 22:05:09
date last changed
2017-10-29 04:07:02
@article{1c2bf4ba-e840-4bc5-bd83-54b7939edb91,
  abstract     = {A high intake of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been associated with reduced levels of blood pressure (BP). Their antihypertensive action may be due to the reduction of the ω-6/ω-3 ratio and the resulting competitive effect of ω-3 as compared to arachidonic acid (an ω-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators. Some functional polymorphisms (SNPs), in genes which encode for the same enzymes, were associated with hypertension and ischemic stroke in the Malmö Diet and Cancer (MDC), a Swedish urban-based longitudinal study. The aim of this study was to evaluate the effect of the intake of different types of PUFAs on BP change over time (Δ-BP; mean follow-up 16.6±1.5 years; n=3.550 with complete phenotypic data), also considering the interaction with SNPs in genes involved in their metabolism via CYP450.},
  author       = {Tagetti, Angela and Ericson, Ulrika and Montagnana, Martina and Danese, Elisa and Almgren, Peter and Nilsson, Peter and Engström, Gunnar and Hedblad, Bo and Minuz, Pietro and Orho-Melander, Marju and Fava, Cristiano and Melander, Olle},
  issn         = {1098-8823},
  language     = {eng},
  number       = {May 16},
  pages        = {126--133},
  publisher    = {Elsevier},
  series       = {Prostaglandins & other Lipid Mediators},
  title        = {Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: Possible interaction with genes involved in 20-HETE and EETs metabolism.},
  url          = {http://dx.doi.org/10.1016/j.prostaglandins.2015.05.003},
  volume       = {120},
  year         = {2015},
}