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Development of Curative Therapies for Ewing Sarcomas by Interdisciplinary Cooperative Groups in Europe.

Bölling, T; Braun-Munzinger, G; Burdach, S; Calaminus, G; Craft, A; Delattre, O; Deley, M-C L; Dirksen, U; Dockhorn-Dworniczak, B and Dunst, J, et al. (2015) In Klinische Pädiatrie 227(3). p.108-115
Abstract
Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.
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organization
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type
Contribution to journal
publication status
published
subject
in
Klinische Pädiatrie
volume
227
issue
3
pages
108 - 115
publisher
Georg Thieme Verlag
external identifiers
  • pmid:25985445
  • wos:000354653100002
  • scopus:84929575169
ISSN
1439-3824
DOI
10.1055/s-0035-1545263
language
English
LU publication?
yes
id
0e2a9337-d16e-40dd-85ce-11b10b504577 (old id 5448991)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25985445?dopt=Abstract
date added to LUP
2015-06-04 21:56:44
date last changed
2017-01-01 03:51:06
@article{0e2a9337-d16e-40dd-85ce-11b10b504577,
  abstract     = {Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.},
  author       = {Bölling, T and Braun-Munzinger, G and Burdach, S and Calaminus, G and Craft, A and Delattre, O and Deley, M-C L and Dirksen, U and Dockhorn-Dworniczak, B and Dunst, J and Engel, S and Faldum, A and Fröhlich, B and Gadner, H and Göbel, U and Gosheger, G and Hardes, J and Hawkins, D S and Hjorth, Lars and Hoffmann, C and Kovar, H and Kruseova, J and Ladenstein, R and Leuschner, I and Lewis, I J and Oberlin, O and Paulussen, M and Potratz, J and Ranft, A and Rössig, C and Rübe, C and Sauer, R and Schober, O and Schuck, A and Timmermann, B and Tirode, F and van den Berg, H and van Valen, F and Vieth, V and Willich, N and Winkelmann, W and Whelan, J and Womer, R B},
  issn         = {1439-3824},
  language     = {eng},
  number       = {3},
  pages        = {108--115},
  publisher    = {Georg Thieme Verlag},
  series       = {Klinische Pädiatrie},
  title        = {Development of Curative Therapies for Ewing Sarcomas by Interdisciplinary Cooperative Groups in Europe.},
  url          = {http://dx.doi.org/10.1055/s-0035-1545263},
  volume       = {227},
  year         = {2015},
}