Spiral av inflammation och koagulopati bakom svår covid-19
(2022) In Lakartidningen 119.- Abstract
Severe Covid-19 has a high mortality rate. Vital organ dysfunction results from pathophysiological self-amplifying loops of innate immunological hyperactivation, cytokine release, complement deposition, endothelial damage, and macro- and microvascular thromboembolism. Resulting alveolar exudation and pulmonary capillary thromboembolism lead to ventilation-perfusion mismatch, considered to be a primary cause of death in severe Covid-19. Therapeutic immunomodulation is believed to be safer and more effective during time periods with decreasing viral exposition and increasing inflammation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/544debda-3deb-4b39-8ee3-b3b515bcf465
- author
- Loo, Kristoffer LU and Åkeson, Jonas LU
- organization
- alternative title
- Severe Covid-19 comprises a self-amplifying loop of inflammation and coagulopathy
- publishing date
- 2022-01-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- COVID-19, COVID-19
- in
- Lakartidningen
- volume
- 119
- publisher
- Swedish Medical Association
- external identifiers
-
- scopus:85123270822
- pmid:34995356
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- 544debda-3deb-4b39-8ee3-b3b515bcf465
- alternative location
- https://lakartidningen.se/wp-content/uploads/2022/01/B21215.pdf
- date added to LUP
- 2022-03-21 10:47:58
- date last changed
- 2024-04-24 04:25:02
@article{544debda-3deb-4b39-8ee3-b3b515bcf465,
abstract = {{<p>Severe Covid-19 has a high mortality rate. Vital organ dysfunction results from pathophysiological self-amplifying loops of innate immunological hyperactivation, cytokine release, complement deposition, endothelial damage, and macro- and microvascular thromboembolism. Resulting alveolar exudation and pulmonary capillary thromboembolism lead to ventilation-perfusion mismatch, considered to be a primary cause of death in severe Covid-19. Therapeutic immunomodulation is believed to be safer and more effective during time periods with decreasing viral exposition and increasing inflammation.</p>}},
author = {{Loo, Kristoffer and Åkeson, Jonas}},
issn = {{0023-7205}},
keywords = {{COVID-19; COVID-19}},
language = {{swe}},
month = {{01}},
publisher = {{Swedish Medical Association}},
series = {{Lakartidningen}},
title = {{Spiral av inflammation och koagulopati bakom svår covid-19}},
url = {{https://lakartidningen.se/wp-content/uploads/2022/01/B21215.pdf}},
volume = {{119}},
year = {{2022}},
}