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Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

Schelbergen, R F ; Geven, E J ; van den Bosch, M H J ; Eriksson, H ; Leanderson, Tomas LU ; Vogl, T ; Roth, J ; van de Loo, F A J ; Koenders, M I and van der Kraan, P M , et al. (2015) In Annals of the Rheumatic Diseases 74(12). p.2254-2258
Abstract
Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We investigated the effect of paquinimod on experimental OA and human OA synovium.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
74
issue
12
pages
2254 - 2258
publisher
BMJ Publishing Group
external identifiers
  • pmid:25969431
  • wos:000365846400029
  • pmid:25969431
  • scopus:84945246230
ISSN
1468-2060
DOI
10.1136/annrheumdis-2014-206517
language
English
LU publication?
yes
id
9a4db149-513a-4f4d-8da3-40c8f85fb27a (old id 5453272)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25969431?dopt=Abstract
date added to LUP
2016-04-01 10:51:43
date last changed
2022-04-04 21:57:17
@article{9a4db149-513a-4f4d-8da3-40c8f85fb27a,
  abstract     = {{Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We investigated the effect of paquinimod on experimental OA and human OA synovium.}},
  author       = {{Schelbergen, R F and Geven, E J and van den Bosch, M H J and Eriksson, H and Leanderson, Tomas and Vogl, T and Roth, J and van de Loo, F A J and Koenders, M I and van der Kraan, P M and van den Berg, W B and Blom, A B and van Lent, P L E M}},
  issn         = {{1468-2060}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2254--2258}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Annals of the Rheumatic Diseases}},
  title        = {{Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.}},
  url          = {{http://dx.doi.org/10.1136/annrheumdis-2014-206517}},
  doi          = {{10.1136/annrheumdis-2014-206517}},
  volume       = {{74}},
  year         = {{2015}},
}