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Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

Schelbergen, R F; Geven, E J; van den Bosch, M H J; Eriksson, H; Leanderson, Tomas LU ; Vogl, T; Roth, J; van de Loo, F A J; Koenders, M I and van der Kraan, P M, et al. (2015) In Annals of the Rheumatic Diseases 74(12). p.2254-2258
Abstract
Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We investigated the effect of paquinimod on experimental OA and human OA synovium.
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Contribution to journal
publication status
published
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in
Annals of the Rheumatic Diseases
volume
74
issue
12
pages
2254 - 2258
publisher
British Medical Association
external identifiers
  • pmid:25969431
  • wos:000365846400029
  • scopus:84945246230
ISSN
1468-2060
DOI
10.1136/annrheumdis-2014-206517
language
English
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yes
id
9a4db149-513a-4f4d-8da3-40c8f85fb27a (old id 5453272)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25969431?dopt=Abstract
date added to LUP
2015-06-04 19:21:58
date last changed
2017-10-22 03:24:19
@article{9a4db149-513a-4f4d-8da3-40c8f85fb27a,
  abstract     = {Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We investigated the effect of paquinimod on experimental OA and human OA synovium.},
  author       = {Schelbergen, R F and Geven, E J and van den Bosch, M H J and Eriksson, H and Leanderson, Tomas and Vogl, T and Roth, J and van de Loo, F A J and Koenders, M I and van der Kraan, P M and van den Berg, W B and Blom, A B and van Lent, P L E M},
  issn         = {1468-2060},
  language     = {eng},
  number       = {12},
  pages        = {2254--2258},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.},
  url          = {http://dx.doi.org/10.1136/annrheumdis-2014-206517},
  volume       = {74},
  year         = {2015},
}