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Central nervous system relapse in peripheral T-cell lymphomas: A Swedish lymphoma registry study.

Ellin, Fredrik LU ; Landström, Jenny; Jerkeman, Mats LU and Relander, Thomas LU (2015) In Blood 126(1). p.36-41
Abstract
Central Nervous System (CNS) relapse in non-Hodgkin lymphomas (NHL) carries a very poor prognosis. Risk factors and outcome have been studied in aggressive B-cell lymphomas but very little is known about the risk in peripheral T-cell lymphoma (PTCL). We aimed at analyzing risk factors for CNS involvement at first relapse or progression, and the outcome of these patients, in a large population-based cohort of PTCL patients. Twenty-eight out of 625 patients (4.5%) developed CNS disease over time. In multivariable analysis disease characteristics at diagnosis independently associated with an increased risk of later CNS involvement were involvement of >1 extranodal site (Hazard Ratio [HR] 2.60, 95% Confidence Interval [95% CI] 1.07-6.29,... (More)
Central Nervous System (CNS) relapse in non-Hodgkin lymphomas (NHL) carries a very poor prognosis. Risk factors and outcome have been studied in aggressive B-cell lymphomas but very little is known about the risk in peripheral T-cell lymphoma (PTCL). We aimed at analyzing risk factors for CNS involvement at first relapse or progression, and the outcome of these patients, in a large population-based cohort of PTCL patients. Twenty-eight out of 625 patients (4.5%) developed CNS disease over time. In multivariable analysis disease characteristics at diagnosis independently associated with an increased risk of later CNS involvement were involvement of >1 extranodal site (Hazard Ratio [HR] 2.60, 95% Confidence Interval [95% CI] 1.07-6.29, p=0.035), skin (HR 3.51, 95% CI 1.26-9.74, p=0.016) and gastrointestinal involvement (HR 3.06, 95% CI 1.30-7.18, p=0.010). The outcome of relapsed/refractory patients was very poor and CNS involvement was not associated with a significantly worse outcome compared to relapsed/refractory patients without CNS involvement in multivariable analysis (HR 1.6, 95% CI 0.96-2.6, p=0.074). The results from the present study indicate that CNS relapse in PTCL occurs at a frequency similar to what is seen in aggressive B-cell lymphomas, but the poor outcomes in relapse are largely driven by systemic rather than CNS disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
126
issue
1
pages
36 - 41
publisher
American Society of Hematology
external identifiers
  • pmid:25957393
  • wos:000357696200009
  • scopus:84937826373
ISSN
1528-0020
DOI
10.1182/blood-2014-12-616961
language
English
LU publication?
yes
id
6a9d6aac-289f-42ae-9ce2-91c9585bcc4c (old id 5453630)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25957393?dopt=Abstract
date added to LUP
2015-06-04 15:25:38
date last changed
2017-09-03 03:12:59
@article{6a9d6aac-289f-42ae-9ce2-91c9585bcc4c,
  abstract     = {Central Nervous System (CNS) relapse in non-Hodgkin lymphomas (NHL) carries a very poor prognosis. Risk factors and outcome have been studied in aggressive B-cell lymphomas but very little is known about the risk in peripheral T-cell lymphoma (PTCL). We aimed at analyzing risk factors for CNS involvement at first relapse or progression, and the outcome of these patients, in a large population-based cohort of PTCL patients. Twenty-eight out of 625 patients (4.5%) developed CNS disease over time. In multivariable analysis disease characteristics at diagnosis independently associated with an increased risk of later CNS involvement were involvement of >1 extranodal site (Hazard Ratio [HR] 2.60, 95% Confidence Interval [95% CI] 1.07-6.29, p=0.035), skin (HR 3.51, 95% CI 1.26-9.74, p=0.016) and gastrointestinal involvement (HR 3.06, 95% CI 1.30-7.18, p=0.010). The outcome of relapsed/refractory patients was very poor and CNS involvement was not associated with a significantly worse outcome compared to relapsed/refractory patients without CNS involvement in multivariable analysis (HR 1.6, 95% CI 0.96-2.6, p=0.074). The results from the present study indicate that CNS relapse in PTCL occurs at a frequency similar to what is seen in aggressive B-cell lymphomas, but the poor outcomes in relapse are largely driven by systemic rather than CNS disease.},
  author       = {Ellin, Fredrik and Landström, Jenny and Jerkeman, Mats and Relander, Thomas},
  issn         = {1528-0020},
  language     = {eng},
  number       = {1},
  pages        = {36--41},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Central nervous system relapse in peripheral T-cell lymphomas: A Swedish lymphoma registry study.},
  url          = {http://dx.doi.org/10.1182/blood-2014-12-616961},
  volume       = {126},
  year         = {2015},
}