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Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-Term Valacyclovir Therapy.

Gnann, John W; Sköldenberg, Birgit; Hart, John; Aurelius, Elisabeth; Schliamser, Silvia LU ; Studahl, Marie; Eriksson, Britt-Marie; Hanley, Daniel; Aoki, Fred and Jackson, Alan C, et al. (2015) In Clinical Infectious Diseases 61(5). p.683-691
Abstract
Despite the proven efficacy of acyclovir therapy, herpes simplex encephalitis (HSE) continues to cause substantial morbidity and mortality. Among patients with HSE treated with acyclovir (ACV), the mortality rate is approximately 14-19%. Among survivors, 45-60% have neuropsychological sequelae at 1 year. Thus, improving therapeutic approaches to HSE remains a high priority.
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Contribution to journal
publication status
published
subject
in
Clinical Infectious Diseases
volume
61
issue
5
pages
683 - 691
publisher
The Infectious Diseases Society of America
external identifiers
  • pmid:25956891
  • wos:000361468700003
  • scopus:84942061344
ISSN
1537-6591
DOI
10.1093/cid/civ369
language
English
LU publication?
yes
id
d9f62c58-30db-4749-b398-65f298f3f0bf (old id 5453682)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25956891?dopt=Abstract
date added to LUP
2015-06-04 15:23:17
date last changed
2017-10-22 03:30:04
@article{d9f62c58-30db-4749-b398-65f298f3f0bf,
  abstract     = {Despite the proven efficacy of acyclovir therapy, herpes simplex encephalitis (HSE) continues to cause substantial morbidity and mortality. Among patients with HSE treated with acyclovir (ACV), the mortality rate is approximately 14-19%. Among survivors, 45-60% have neuropsychological sequelae at 1 year. Thus, improving therapeutic approaches to HSE remains a high priority.},
  author       = {Gnann, John W and Sköldenberg, Birgit and Hart, John and Aurelius, Elisabeth and Schliamser, Silvia and Studahl, Marie and Eriksson, Britt-Marie and Hanley, Daniel and Aoki, Fred and Jackson, Alan C and Griffiths, Paul and Miedzinski, Lil and Hanfelt-Goade, Diane and Hinthorn, Daniel and Ahlm, Clas and Aksamit, Allen and Cruz-Flores, Salvador and Dale, Ilet and Cloud, Gretchen and Jester, Penelope and Whitley, Richard J},
  issn         = {1537-6591},
  language     = {eng},
  number       = {5},
  pages        = {683--691},
  publisher    = {The Infectious Diseases Society of America},
  series       = {Clinical Infectious Diseases},
  title        = {Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-Term Valacyclovir Therapy.},
  url          = {http://dx.doi.org/10.1093/cid/civ369},
  volume       = {61},
  year         = {2015},
}