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Non-ionic contrast media in acrylic bone cement

Kjellson, Fred LU (2005)
Abstract
Non-ionic, water-soluble, contrast media, iohexol and/or iodixanol, have been investigated for use in acrylic bone cement aimed for arthroplasty.



Bone cement, containing the new particulate contrast media , was investigated for: quasi-static mechanical properties, water uptake properties, release of contrast media from the bone cement, biological responses from particulate bone cement, polymerisation reaction, polymerisation temperature, glass transition temperature, injectability and penetration into human cancellous bone, and radiopacity.



The quasi-static mechanical properties of acrylic bone cement are influenced by the size and amount of contrast media in the bone cement; the particle size of... (More)
Non-ionic, water-soluble, contrast media, iohexol and/or iodixanol, have been investigated for use in acrylic bone cement aimed for arthroplasty.



Bone cement, containing the new particulate contrast media , was investigated for: quasi-static mechanical properties, water uptake properties, release of contrast media from the bone cement, biological responses from particulate bone cement, polymerisation reaction, polymerisation temperature, glass transition temperature, injectability and penetration into human cancellous bone, and radiopacity.



The quasi-static mechanical properties of acrylic bone cement are influenced by the size and amount of contrast media in the bone cement; the particle size of iodixanol should be above 8 µm in order to have good mechanical properties. At a ratio of 8 wt%, good tensile strength is achieved while creating clear images on a standard X-ray.



The molecular weight and glass transition temperature of the cement are not affected by the addition of iodixanol; however, iodixanol does lower the maximum polymerisation temperature.



Both iohexol and iodixanol show better biocompatibility than conventional contrast medium; cement particles with iodixanol induce higher bone resorption in vitro than particles with iohexol, and there is a trend that particles with iodixanol show increased bone formation compared to particles with iohexol.



The release of iohexol or iodixanol from wet bone cement does not result in a discernable radiolucent zone in the bone cement. The water uptake of cement containing iohexol is significantly higher than that of cement containing iodixanol, which shows higher water uptake than Palacos R.



High viscosity cement (Palacos R) achieves better penetration into human cancellous bone in femoral heads than low viscosity cement (Osteopal). Cement containing iodixanol achieves higher bone cement penetration and injectability than low viscosity cement, but lower than Palacos R.



The attenuation of X-rays in a contrast medium should be investigated in a standardised way using clinically relevant exposures. Therefore, the attenuation of bone cements (for use in hip- or knee- operations) should be investigated using an X-ray tube voltage of 70 ? 80 kV, with 0.1 m of water as a soft tissue phantom. At 80 kV, with water (similar to clinical situations), iodixanol attenuates photons to the same degree as equal amounts of ZrO2. (Less)
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author
supervisor
opponent
  • Professor Orr, John, Queen's University Belfast, UK
organization
publishing date
type
Thesis
publication status
published
subject
keywords
traumatology, Kirurgi, ortopedi, traumatologi, Material technology, Materiallära, materialteknik, PMMA, Bone cement, particle size, contrast media, radiopacity, iohexol, iodixanol, Clinical physics, radiology, tomography, medical instrumentation, Klinisk fysiologi, radiologi, tomografi, orthopaedics, Surgery, medicinsk instrumentering
pages
104 pages
publisher
Department of Orthopaedics, Lund University
defense location
Föreläsningssal F1 Centralblocket, Universitetssjukhuset i Lund
defense date
2005-10-07 13:15:00
ISBN
91-85439-66-5
language
English
LU publication?
yes
additional info
F Kjellson, JS Wang, T Almén, A Mattsson, J Klaveness, KE Tanner and L Lidgren. 2001. Tensile properties of a bone cement containing non-ionic contrast media J Mater Sci Mater Med, vol 12 pp 889-94.
F Kjellson, B Brudeli, ID McCarthy and L Lidgren. 2004. Water uptake and release from iodine-containing bone cement J Biomed Mater Res A, vol 71 pp 292-8.
JS Wang, J Diaz, A Sabokbar, N Athanasou, F Kjellson, KE Tanner, ID McCarty and L Lidgren. 2005. In vitro and in vivo biological responses to a novel radiopacifying agent for bone cement J Roy Soc Interface, vol 2 pp 71-8.
F Kjellson, S Abdulghani, KE Tanner, ID McCarthy and L Lidgren. . Effect of iodixanol particle size on the mechanical properties of a PMMA based bone cement (submitted)
S Abdulghani, F Kjellson, J-S Wang and L Lidgren. . Low viscosity cement does not improve bone cement penetration in human femoral heads (submitted)
F Kjellson, T Almén, KE Tanner, ID McCarthy and L Lidgren. 2004. Bone cement X-ray contrast media: a clinically relevant method of measuring their efficacy J Biomed Mater Res, vol 70B pp 354-61.
id
23a31ebb-6808-4f45-92f4-22dc914319dd (old id 545411)
date added to LUP
2016-04-01 15:59:01
date last changed
2018-11-21 20:37:52
@phdthesis{23a31ebb-6808-4f45-92f4-22dc914319dd,
  abstract     = {{Non-ionic, water-soluble, contrast media, iohexol and/or iodixanol, have been investigated for use in acrylic bone cement aimed for arthroplasty.<br/><br>
<br/><br>
Bone cement, containing the new particulate contrast media , was investigated for: quasi-static mechanical properties, water uptake properties, release of contrast media from the bone cement, biological responses from particulate bone cement, polymerisation reaction, polymerisation temperature, glass transition temperature, injectability and penetration into human cancellous bone, and radiopacity.<br/><br>
<br/><br>
The quasi-static mechanical properties of acrylic bone cement are influenced by the size and amount of contrast media in the bone cement; the particle size of iodixanol should be above 8 µm in order to have good mechanical properties. At a ratio of 8 wt%, good tensile strength is achieved while creating clear images on a standard X-ray.<br/><br>
<br/><br>
The molecular weight and glass transition temperature of the cement are not affected by the addition of iodixanol; however, iodixanol does lower the maximum polymerisation temperature.<br/><br>
<br/><br>
Both iohexol and iodixanol show better biocompatibility than conventional contrast medium; cement particles with iodixanol induce higher bone resorption in vitro than particles with iohexol, and there is a trend that particles with iodixanol show increased bone formation compared to particles with iohexol.<br/><br>
<br/><br>
The release of iohexol or iodixanol from wet bone cement does not result in a discernable radiolucent zone in the bone cement. The water uptake of cement containing iohexol is significantly higher than that of cement containing iodixanol, which shows higher water uptake than Palacos R.<br/><br>
<br/><br>
High viscosity cement (Palacos R) achieves better penetration into human cancellous bone in femoral heads than low viscosity cement (Osteopal). Cement containing iodixanol achieves higher bone cement penetration and injectability than low viscosity cement, but lower than Palacos R.<br/><br>
<br/><br>
The attenuation of X-rays in a contrast medium should be investigated in a standardised way using clinically relevant exposures. Therefore, the attenuation of bone cements (for use in hip- or knee- operations) should be investigated using an X-ray tube voltage of 70 ? 80 kV, with 0.1 m of water as a soft tissue phantom. At 80 kV, with water (similar to clinical situations), iodixanol attenuates photons to the same degree as equal amounts of ZrO2.}},
  author       = {{Kjellson, Fred}},
  isbn         = {{91-85439-66-5}},
  keywords     = {{traumatology; Kirurgi; ortopedi; traumatologi; Material technology; Materiallära; materialteknik; PMMA; Bone cement; particle size; contrast media; radiopacity; iohexol; iodixanol; Clinical physics; radiology; tomography; medical instrumentation; Klinisk fysiologi; radiologi; tomografi; orthopaedics; Surgery; medicinsk instrumentering}},
  language     = {{eng}},
  publisher    = {{Department of Orthopaedics, Lund University}},
  school       = {{Lund University}},
  title        = {{Non-ionic contrast media in acrylic bone cement}},
  year         = {{2005}},
}