Dysfunctional but viable myocardium - ischemic heart disease assessed by magnetic resonance imaging and single photon emission computed tomography
(2005)- Abstract
- The assessment of ischemic heart disease (IHD) often focuses on the detection of dysfunctional but viable myocardium which may improve in function following revascularization. Dysfunctional but viable myocardium is identified by distinct characteristics with regards to function, perfusion and viability. Therefore, in Paper I we developed a method for quantitative polar representation of left ventricular myocardial function, perfusion and viability using single photon emission computed tomography (SPECT) and cardiac magnetic resonance (CMR). Polar representation of these parameters was feasible, and the quantitative method agreed with visual assessment.
Paper II showed that wall thickening decreases with increasing... (More) - The assessment of ischemic heart disease (IHD) often focuses on the detection of dysfunctional but viable myocardium which may improve in function following revascularization. Dysfunctional but viable myocardium is identified by distinct characteristics with regards to function, perfusion and viability. Therefore, in Paper I we developed a method for quantitative polar representation of left ventricular myocardial function, perfusion and viability using single photon emission computed tomography (SPECT) and cardiac magnetic resonance (CMR). Polar representation of these parameters was feasible, and the quantitative method agreed with visual assessment.
Paper II showed that wall thickening decreases with increasing infarct transmurality. However, the variation in wall thickening was large, and importantly, influenced more so by the function of adjacent myocardium than by infarct transmurality. This underscores the difficulty of using resting function alone to accurately assess myocardial infarction in revascularized IHD.
In Paper III we assessed the relationship between left ventricular ejection fraction (LVEF) and infarct size and found that LVEF cannot be used to estimate infarct size, and vice versa. However, the study showed that LVEF can be used to estimate a maximum predicted infarct size, and that infarct size can be used to estimate a maximum predicted LVEF. These results emphasize the importance of direct infarct imaging by CMR when attempting to estimate the size of infarction in patients with IHD.
Paper IV was designed to assess the time course of recovery of myocardial perfusion and function after revascularization. The recovery of perfusion was found to occur in the first month, while the recovery of function was delayed in segments with non-transmural infarction.
In summary, the presented studies emphasize the importance of direct infarct imaging by CMR for the accurate identification of infarction in the assessment of dysfunctional myocardium. Neither regional nor global myocardial function have a close correlation to infarction, but the presence of non-transmural infarction is a marker for delayed recovery of function following revascularization. (Less) - Abstract (Swedish)
- Popular Abstract in Swedish
En hjärtinfarkt definieras som celldöd i hjärtmuskeln, och om celldöden är omfattande, orsakar den en oåterkallelig nedsättning i hjärtats pumpfunktion. Pumpfunktionen kan även vara långvarigt nedsatt p.g.a. att hjärtat inte får tillräckligt med blod. Man kan då förbättra pumpfunktionen genom att återställa blodtillförseln med en operation. För att kunna hitta områden i hjärtat med nedsatt funktion men levande hjärtmuskel ("dysfunctional but viable myocardium") är det nödvändigt att bedöma tre egenskaper: (1) hjärtats pumpfunktion, (2) dess genomblödning (perfusion) och (3) huruvida cellerna lever eller ej.
Delarbete I beskriver utvecklingen av en ny metod för att objektivt... (More) - Popular Abstract in Swedish
En hjärtinfarkt definieras som celldöd i hjärtmuskeln, och om celldöden är omfattande, orsakar den en oåterkallelig nedsättning i hjärtats pumpfunktion. Pumpfunktionen kan även vara långvarigt nedsatt p.g.a. att hjärtat inte får tillräckligt med blod. Man kan då förbättra pumpfunktionen genom att återställa blodtillförseln med en operation. För att kunna hitta områden i hjärtat med nedsatt funktion men levande hjärtmuskel ("dysfunctional but viable myocardium") är det nödvändigt att bedöma tre egenskaper: (1) hjärtats pumpfunktion, (2) dess genomblödning (perfusion) och (3) huruvida cellerna lever eller ej.
Delarbete I beskriver utvecklingen av en ny metod för att objektivt mäta dessa tre egenskaper med hjälp av funktionsbilder och infarktbilder från magnetisk resonanstomografi (MR) och bilder av perfusion från SPECT (en metod för att avbilda hjärtmuskelns genomblödning med en radioaktiv isotop som injiceras i blodet). Metoden implementerades och mätresultaten visade god överensstämmelse med visuell bedömning.
Delarbete II visar att pumpfunktionen i ett område beror mer på funktionen i omgivande hjärtmuskel än på utbredningen av infarkt i området. Delarbete III visar att hjärtats totala pumpfunktion varierar påtagligt i förhållande till den totala infarktstorleken, men att det föreligger en maximalt förväntad pumpfunktion i förhållande till infarktstorlek. Dessa arbeten visar att det varken går att påvisa eller utesluta förekomsten av infarkt genom att endast värdera pumpfunktionen.
Delarbete IV visar att även om perfusionen ökar tidigt efter en operation så kan funktionsåterhämtningen i levande hjärtmuskel vara fördröjd i områden i nära anslutning till infarkt. Detta ökar vår förståelse för återhämtningsförloppet efter en operation.
Varken regional eller total pumpfunktion korrelerar starkt till infarkt, men områden som delvis drabbats av infarkt uppvisar fördröjd funktionsåterhämtning efter operation. Sammanfattningsvis visar avhandlingen på vikten av att direkt avbilda infarkt med MR för att kunna bedöma möjligheten till funktionsåterhämtning i hjärtmuskel efter operation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/545445
- author
- Ugander, Martin LU
- supervisor
- opponent
-
- M.D., Professor Bonow, Robert O., Division of Cardiology, Northwestern University, Chicago, IL, USA
- organization
- publishing date
- 2005
- type
- Thesis
- publication status
- published
- subject
- keywords
- medicinsk instrumentering, tomografi, radiologi, medical instrumentation, Klinisk fysiologi, radiology, tomography, Clinical physics, non-invasive imaging, myocardial infarction, viability, Physiology, Fysiologi, Cardiovascular system, Kardiovaskulära systemet
- pages
- 155 pages
- publisher
- Department of Clinical Physiology, Lund University
- defense location
- Segerfalksalen, Wallenberg Neuroscience Center, Sölvegatan 17, Lund, Sweden
- defense date
- 2006-02-04 10:00:00
- ISBN
- 91-85439-84-3
- language
- English
- LU publication?
- yes
- additional info
- PA Cain, M Ugander, J Palmer, M Carlsson, E Heiberg and H Arheden. 2005. Quantitative polar representation of left ventricular myocardial perfusion, function and viability using SPECT and cardiac magnetic resonance: initial results. Clin Physiol Funct Imaging., vol 25 pp 215-222.M Ugander, PA Cain, A Perron, E Hedström and H Arheden. 2005. Infarct transmurality and adjacent segmental function as determinants of wall thickening in revascularized chronic ischemic heart disease. Clin Physiol Funct Imaging., vol 25 pp 209-214.M Ugander, B Ekmehag and H Arheden. . A maximum predicted left ventricular ejection fraction in relation to infarct size in patients with ischemic heart disease. (submitted)M Ugander, P Cain, P Johnsson, J Palmer and H Arheden. . Influence of the presence of chronic non-transmural myocardial infarction on the time course of perfusion and functional recovery after revascularization. (manuscript)
- id
- 35ef5ea6-43b7-4069-a2cb-35f7c73a8d63 (old id 545445)
- date added to LUP
- 2016-04-01 15:19:01
- date last changed
- 2022-01-25 13:42:42
@phdthesis{35ef5ea6-43b7-4069-a2cb-35f7c73a8d63, abstract = {{The assessment of ischemic heart disease (IHD) often focuses on the detection of dysfunctional but viable myocardium which may improve in function following revascularization. Dysfunctional but viable myocardium is identified by distinct characteristics with regards to function, perfusion and viability. Therefore, in Paper I we developed a method for quantitative polar representation of left ventricular myocardial function, perfusion and viability using single photon emission computed tomography (SPECT) and cardiac magnetic resonance (CMR). Polar representation of these parameters was feasible, and the quantitative method agreed with visual assessment.<br/><br> <br/><br> Paper II showed that wall thickening decreases with increasing infarct transmurality. However, the variation in wall thickening was large, and importantly, influenced more so by the function of adjacent myocardium than by infarct transmurality. This underscores the difficulty of using resting function alone to accurately assess myocardial infarction in revascularized IHD.<br/><br> <br/><br> In Paper III we assessed the relationship between left ventricular ejection fraction (LVEF) and infarct size and found that LVEF cannot be used to estimate infarct size, and vice versa. However, the study showed that LVEF can be used to estimate a maximum predicted infarct size, and that infarct size can be used to estimate a maximum predicted LVEF. These results emphasize the importance of direct infarct imaging by CMR when attempting to estimate the size of infarction in patients with IHD.<br/><br> <br/><br> Paper IV was designed to assess the time course of recovery of myocardial perfusion and function after revascularization. The recovery of perfusion was found to occur in the first month, while the recovery of function was delayed in segments with non-transmural infarction.<br/><br> <br/><br> In summary, the presented studies emphasize the importance of direct infarct imaging by CMR for the accurate identification of infarction in the assessment of dysfunctional myocardium. Neither regional nor global myocardial function have a close correlation to infarction, but the presence of non-transmural infarction is a marker for delayed recovery of function following revascularization.}}, author = {{Ugander, Martin}}, isbn = {{91-85439-84-3}}, keywords = {{medicinsk instrumentering; tomografi; radiologi; medical instrumentation; Klinisk fysiologi; radiology; tomography; Clinical physics; non-invasive imaging; myocardial infarction; viability; Physiology; Fysiologi; Cardiovascular system; Kardiovaskulära systemet}}, language = {{eng}}, publisher = {{Department of Clinical Physiology, Lund University}}, school = {{Lund University}}, title = {{Dysfunctional but viable myocardium - ischemic heart disease assessed by magnetic resonance imaging and single photon emission computed tomography}}, url = {{https://lup.lub.lu.se/search/files/4365636/545446.pdf}}, year = {{2005}}, }