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Acute pancreatitis : a prospective study on incidence, etiology, and outcome

Vidarsdottir, Hanna; Möller, Pall H LU ; Vidarsdottir, Halla LU ; Thorarinsdottir, Hildur and Björnsson, Einar S (2013) In European Journal of Gastroenterology and Hepatology 25(9). p.75-1068
Abstract

BACKGROUND AND AIMS: Prospective and population-based studies on the incidence of acute pancreatitis (AP) are lacking. Alcohol consumption has increased considerably in Iceland during the last decade. We aimed to determine the incidence, etiology, severity, and complications of AP and compare the results with a previous study on AP in Iceland.

METHODS: A prospective population-based study of patients diagnosed with AP at the National University Hospital of Iceland during 1 year (2010-2011). Information on symptoms, etiology, and complications was registered.

RESULTS: During the study period, 134 patients were diagnosed with AP, 78 men (58%), median age 57 years (interquartile range 42-71). Overall, 89/104 (86%) patients had... (More)

BACKGROUND AND AIMS: Prospective and population-based studies on the incidence of acute pancreatitis (AP) are lacking. Alcohol consumption has increased considerably in Iceland during the last decade. We aimed to determine the incidence, etiology, severity, and complications of AP and compare the results with a previous study on AP in Iceland.

METHODS: A prospective population-based study of patients diagnosed with AP at the National University Hospital of Iceland during 1 year (2010-2011). Information on symptoms, etiology, and complications was registered.

RESULTS: During the study period, 134 patients were diagnosed with AP, 78 men (58%), median age 57 years (interquartile range 42-71). Overall, 89/104 (86%) patients had their first attack of pancreatitis, yielding a crude incidence of 40/100 000 inhabitants/year. The major etiological groups were as follows: gallstones, 52 cases (42%); alcohol 29, (23%); postendoscopic retrograde cholangio-pancreatography in 12 (9.5%); medications in eight (6.3%); and idiopathic in 15 (12%). Alcohol was more often the cause in men (25 vs. 4, P<0.05) but the incidence of gallstone-induced pancreatitis was similar in men and women (26 vs. 27). Seven patients had severe complications, three had pancreatic necrosis, two had pseudocysts, and one developed renal failure. Another patient developed acute respiratory distress syndrome and was admitted to the ICU. No patient died of AP during the study period.

CONCLUSION: The incidence of AP has not increased significantly in Iceland in the last decade. Alcohol-induced pancreatitis has not increased proportionally despite increased alcohol consumption in Iceland. In a population-based setting, the vast majority of AP is of mild severity.

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publishing date
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Contribution to journal
publication status
published
keywords
Acute Disease, Adult, Aged, Aged, 80 and over, Alcohol Drinking, Female, Hospitals, University, Humans, Iceland, Incidence, Male, Middle Aged, Pancreatic Pseudocyst, Pancreatitis, Pancreatitis, Acute Necrotizing, Pancreatitis, Alcoholic, Prospective Studies, Renal Insufficiency, Respiratory Distress Syndrome, Adult, Risk Factors, Severity of Illness Index, Time Factors, Young Adult, Journal Article
in
European Journal of Gastroenterology and Hepatology
volume
25
issue
9
pages
8 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:84881369676
ISSN
1473-5687
DOI
10.1097/MEG.0b013e3283640fc8
language
English
LU publication?
no
id
54546271-5bfc-4dc8-abf8-ad88491e3c9d
date added to LUP
2016-11-17 14:09:41
date last changed
2018-05-29 11:35:27
@article{54546271-5bfc-4dc8-abf8-ad88491e3c9d,
  abstract     = {<p>BACKGROUND AND AIMS: Prospective and population-based studies on the incidence of acute pancreatitis (AP) are lacking. Alcohol consumption has increased considerably in Iceland during the last decade. We aimed to determine the incidence, etiology, severity, and complications of AP and compare the results with a previous study on AP in Iceland.</p><p>METHODS: A prospective population-based study of patients diagnosed with AP at the National University Hospital of Iceland during 1 year (2010-2011). Information on symptoms, etiology, and complications was registered.</p><p>RESULTS: During the study period, 134 patients were diagnosed with AP, 78 men (58%), median age 57 years (interquartile range 42-71). Overall, 89/104 (86%) patients had their first attack of pancreatitis, yielding a crude incidence of 40/100 000 inhabitants/year. The major etiological groups were as follows: gallstones, 52 cases (42%); alcohol 29, (23%); postendoscopic retrograde cholangio-pancreatography in 12 (9.5%); medications in eight (6.3%); and idiopathic in 15 (12%). Alcohol was more often the cause in men (25 vs. 4, P&lt;0.05) but the incidence of gallstone-induced pancreatitis was similar in men and women (26 vs. 27). Seven patients had severe complications, three had pancreatic necrosis, two had pseudocysts, and one developed renal failure. Another patient developed acute respiratory distress syndrome and was admitted to the ICU. No patient died of AP during the study period.</p><p>CONCLUSION: The incidence of AP has not increased significantly in Iceland in the last decade. Alcohol-induced pancreatitis has not increased proportionally despite increased alcohol consumption in Iceland. In a population-based setting, the vast majority of AP is of mild severity.</p>},
  author       = {Vidarsdottir, Hanna and Möller, Pall H and Vidarsdottir, Halla and Thorarinsdottir, Hildur and Björnsson, Einar S},
  issn         = {1473-5687},
  keyword      = {Acute Disease,Adult,Aged,Aged, 80 and over,Alcohol Drinking,Female,Hospitals, University,Humans,Iceland,Incidence,Male,Middle Aged,Pancreatic Pseudocyst,Pancreatitis,Pancreatitis, Acute Necrotizing,Pancreatitis, Alcoholic,Prospective Studies,Renal Insufficiency,Respiratory Distress Syndrome, Adult,Risk Factors,Severity of Illness Index,Time Factors,Young Adult,Journal Article},
  language     = {eng},
  number       = {9},
  pages        = {75--1068},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Gastroenterology and Hepatology},
  title        = {Acute pancreatitis : a prospective study on incidence, etiology, and outcome},
  url          = {http://dx.doi.org/10.1097/MEG.0b013e3283640fc8},
  volume       = {25},
  year         = {2013},
}