OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for primary prevention of osteoarthritis by joint injury prevention in sport and recreation.
Emery, C A ; Roos, E M ; Verhagen, E ; Finch, C F ; Bennell, K L ; Story, B ; Spindler, K ; Kemp, J and Lohmander, Stefan LU
(2015)
In Osteoarthritis and Cartilage
23(5).
p.815-825
- Abstract
- The risk of post-traumatic osteoarthritis (PTOA) substantially increases following joint injury. Research efforts should focus on investigating the efficacy of preventative strategies in high quality randomized controlled trials (RCT). The objective of these OARSI RCT recommendations is to inform the design, conduct and analytical approaches to RCTs evaluating the preventative effect of joint injury prevention strategies. Recommendations regarding the design, conduct, and reporting of RCTs evaluating injury prevention interventions were established based on the consensus of nine researchers internationally with expertise in epidemiology, injury prevention and/or osteoarthritis (OA). Input and resultant consensus was established through... (More)
- The risk of post-traumatic osteoarthritis (PTOA) substantially increases following joint injury. Research efforts should focus on investigating the efficacy of preventative strategies in high quality randomized controlled trials (RCT). The objective of these OARSI RCT recommendations is to inform the design, conduct and analytical approaches to RCTs evaluating the preventative effect of joint injury prevention strategies. Recommendations regarding the design, conduct, and reporting of RCTs evaluating injury prevention interventions were established based on the consensus of nine researchers internationally with expertise in epidemiology, injury prevention and/or osteoarthritis (OA). Input and resultant consensus was established through teleconference, face to face and email correspondence over a 1 year period. Recommendations for injury prevention RCTs include context specific considerations regarding the research question, research design, study participants, randomization, baseline characteristics, intervention, outcome measurement, analysis, implementation, cost evaluation, reporting and future considerations including the impact on development of PTOA. Methodological recommendations for injury prevention RCTs are critical to informing evidence-based practice and policy decisions in health care, public health and the community. Recommendations regarding the interpretation and conduct of injury prevention RCTs will inform the highest level of evidence in the field. These recommendations will facilitate between study comparisons to inform best practice in injury prevention that will have the greatest public health impact. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5456692
- author
- Emery, C A
; Roos, E M
; Verhagen, E
; Finch, C F
; Bennell, K L
; Story, B
; Spindler, K
; Kemp, J
and Lohmander, Stefan
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Osteoarthritis and Cartilage
- volume
- 23
- issue
- 5
- pages
- 815 - 825
- publisher
- W.B. Saunders
- external identifiers
-
- pmid:25952352
- wos:000353821200014
- scopus:84933514047
- pmid:25952352
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2015.03.009
- language
- English
- LU publication?
- yes
- id
- 99018523-fd50-428d-8923-08c89191fe37 (old id 5456692)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25952352?dopt=Abstract
- date added to LUP
- 2016-04-01 11:02:58
- date last changed
- 2025-04-04 14:30:58
@article{99018523-fd50-428d-8923-08c89191fe37,
abstract = {{The risk of post-traumatic osteoarthritis (PTOA) substantially increases following joint injury. Research efforts should focus on investigating the efficacy of preventative strategies in high quality randomized controlled trials (RCT). The objective of these OARSI RCT recommendations is to inform the design, conduct and analytical approaches to RCTs evaluating the preventative effect of joint injury prevention strategies. Recommendations regarding the design, conduct, and reporting of RCTs evaluating injury prevention interventions were established based on the consensus of nine researchers internationally with expertise in epidemiology, injury prevention and/or osteoarthritis (OA). Input and resultant consensus was established through teleconference, face to face and email correspondence over a 1 year period. Recommendations for injury prevention RCTs include context specific considerations regarding the research question, research design, study participants, randomization, baseline characteristics, intervention, outcome measurement, analysis, implementation, cost evaluation, reporting and future considerations including the impact on development of PTOA. Methodological recommendations for injury prevention RCTs are critical to informing evidence-based practice and policy decisions in health care, public health and the community. Recommendations regarding the interpretation and conduct of injury prevention RCTs will inform the highest level of evidence in the field. These recommendations will facilitate between study comparisons to inform best practice in injury prevention that will have the greatest public health impact.}},
author = {{Emery, C A and Roos, E M and Verhagen, E and Finch, C F and Bennell, K L and Story, B and Spindler, K and Kemp, J and Lohmander, Stefan}},
issn = {{1063-4584}},
language = {{eng}},
number = {{5}},
pages = {{815--825}},
publisher = {{W.B. Saunders}},
series = {{Osteoarthritis and Cartilage}},
title = {{OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for primary prevention of osteoarthritis by joint injury prevention in sport and recreation.}},
url = {{http://dx.doi.org/10.1016/j.joca.2015.03.009}},
doi = {{10.1016/j.joca.2015.03.009}},
volume = {{23}},
year = {{2015}},
}