Advanced

Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors?

Currow, David C; Quinn, Stephen; Ekström, Magnus LU ; Kaasa, Stein; Johnson, Miriam J; Somogyi, Andrew A and Klepstad, Päl (2015) In BMJ Open 5(5).
Abstract
Opioids modulate the perception of breathlessness with a considerable variation in response, with poor correlation between the required opioid dose and symptom severity. The objective of this hypothesis-generating, secondary analysis was to identify candidate single nucleotide polymorphisms (SNP) from those associated with opioid receptors, signalling or pain modulation to identify any related to intensity of breathlessness while on opioids. This can help to inform prospective studies and potentially lead to better tailoring of opioid therapy for refractory breathlessness.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMJ Open
volume
5
issue
5
publisher
British Medical Journal Publishing Group
external identifiers
  • pmid:25948405
  • wos:000354648100014
  • scopus:84930226948
ISSN
2044-6055
DOI
10.1136/bmjopen-2014-006818
language
English
LU publication?
yes
id
2de15f45-953d-4473-a341-0a0f74e81f0c (old id 5456772)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25948405?dopt=Abstract
date added to LUP
2015-06-02 15:57:18
date last changed
2017-10-29 04:01:07
@article{2de15f45-953d-4473-a341-0a0f74e81f0c,
  abstract     = {Opioids modulate the perception of breathlessness with a considerable variation in response, with poor correlation between the required opioid dose and symptom severity. The objective of this hypothesis-generating, secondary analysis was to identify candidate single nucleotide polymorphisms (SNP) from those associated with opioid receptors, signalling or pain modulation to identify any related to intensity of breathlessness while on opioids. This can help to inform prospective studies and potentially lead to better tailoring of opioid therapy for refractory breathlessness.},
  articleno    = {e006818},
  author       = {Currow, David C and Quinn, Stephen and Ekström, Magnus and Kaasa, Stein and Johnson, Miriam J and Somogyi, Andrew A and Klepstad, Päl},
  issn         = {2044-6055},
  language     = {eng},
  number       = {5},
  publisher    = {British Medical Journal Publishing Group},
  series       = {BMJ Open},
  title        = {Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors?},
  url          = {http://dx.doi.org/10.1136/bmjopen-2014-006818},
  volume       = {5},
  year         = {2015},
}