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Retinal structure in young patients aged 10 years or less with Best vitelliform macular dystrophy.

Schatz, Patrik LU ; Sharon, Dror; Al-Hamdani, Sermed; Andréasson, Sten LU and Larsen, Michael (2015) In Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Abstract
Our aim was to analyze retinal structure in young patients with Best disease with reference to future gene therapy. This was a retrospective observational spectral domain optical coherence tomography study of four patients aged 10 years or less with Best disease.

Findings ranged from subtle thickening at the level of the retinal pigment epithelium-photoreceptor interdigitation line, to subretinal fluid and precipitate-like changes at the level of the photoreceptor outer segments, and further to choroidal neovascularization. The photoreceptor inner segment ellipsoid layer could be visualized seemingly undisturbed above the vitelliform lesions, except in the case of choroidal neovascularization.

Clinical variability is... (More)
Our aim was to analyze retinal structure in young patients with Best disease with reference to future gene therapy. This was a retrospective observational spectral domain optical coherence tomography study of four patients aged 10 years or less with Best disease.

Findings ranged from subtle thickening at the level of the retinal pigment epithelium-photoreceptor interdigitation line, to subretinal fluid and precipitate-like changes at the level of the photoreceptor outer segments, and further to choroidal neovascularization. The photoreceptor inner segment ellipsoid layer could be visualized seemingly undisturbed above the vitelliform lesions, except in the case of choroidal neovascularization.

Clinical variability is evident even among young patients aged 10 years or less with Best disease. The earliest structural alterations seem to occur at the level of the retinal pigment epithelium-photoreceptor interdigitation line. The photoreceptor inner segment seems to be unaffected unless choroidal neovascularization develops, which seems promising regarding future gene therapy. (Less)
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Contribution to journal
publication status
published
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Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
publisher
Springer
external identifiers
  • pmid:25940553
  • scopus:84955730477
  • wos:000370004300002
ISSN
1435-702X
DOI
10.1007/s00417-015-3025-z
language
English
LU publication?
yes
id
5419893d-d3ff-4972-bb0b-1d02f6f4b8e4 (old id 5457010)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25940553?dopt=Abstract
date added to LUP
2015-06-04 13:46:46
date last changed
2017-04-02 03:39:59
@article{5419893d-d3ff-4972-bb0b-1d02f6f4b8e4,
  abstract     = {Our aim was to analyze retinal structure in young patients with Best disease with reference to future gene therapy. This was a retrospective observational spectral domain optical coherence tomography study of four patients aged 10 years or less with Best disease.<br/><br>
Findings ranged from subtle thickening at the level of the retinal pigment epithelium-photoreceptor interdigitation line, to subretinal fluid and precipitate-like changes at the level of the photoreceptor outer segments, and further to choroidal neovascularization. The photoreceptor inner segment ellipsoid layer could be visualized seemingly undisturbed above the vitelliform lesions, except in the case of choroidal neovascularization.<br/><br>
Clinical variability is evident even among young patients aged 10 years or less with Best disease. The earliest structural alterations seem to occur at the level of the retinal pigment epithelium-photoreceptor interdigitation line. The photoreceptor inner segment seems to be unaffected unless choroidal neovascularization develops, which seems promising regarding future gene therapy.},
  author       = {Schatz, Patrik and Sharon, Dror and Al-Hamdani, Sermed and Andréasson, Sten and Larsen, Michael},
  issn         = {1435-702X},
  language     = {eng},
  month        = {05},
  publisher    = {Springer},
  series       = {Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie},
  title        = {Retinal structure in young patients aged 10 years or less with Best vitelliform macular dystrophy.},
  url          = {http://dx.doi.org/10.1007/s00417-015-3025-z},
  year         = {2015},
}