Advanced

Characterization of long-term motor deficits in the 6-OHDA model of Parkinson's disease in the common marmoset.

Santana, M; Palmér, Tobias LU ; Simplício, H; Fuentes, R and Petersson, Per LU (2015) In Behavioural Brain Research 290. p.90-101
Abstract
Research aimed at developing new therapies for Parkinson's disease (PD) critically depend on valid animal models of the disease that allows for repeated testing of motor disabilities over extended time periods. We here present an extensive characterization of a wide range of motor symptoms in the 6-OHDA marmoset model of PD when tested over several months. The severity of motor deficits was quantified in two ways: (i) through manual scoring protocols appropriately adapted to include species specific motor behavior and (ii) using automated quantitative motion tracking based on image processing of the digital video recordings. We show that the automated methods allow for rapid and reliable characterization of motor dysfunctions, thus... (More)
Research aimed at developing new therapies for Parkinson's disease (PD) critically depend on valid animal models of the disease that allows for repeated testing of motor disabilities over extended time periods. We here present an extensive characterization of a wide range of motor symptoms in the 6-OHDA marmoset model of PD when tested over several months. The severity of motor deficits was quantified in two ways: (i) through manual scoring protocols appropriately adapted to include species specific motor behavior and (ii) using automated quantitative motion tracking based on image processing of the digital video recordings. We show that the automated methods allow for rapid and reliable characterization of motor dysfunctions, thus complementing the manual scoring procedures, and that robust motor symptoms lasting for several months could be induced when using a two-stage neurotoxic lesioning procedure involving one hemisphere at a time. This non-human primate model of PD should therefore be well suited for long-term evaluation of novel therapies for treatment of PD. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Behavioural Brain Research
volume
290
pages
90 - 101
publisher
Elsevier
external identifiers
  • pmid:25934488
  • wos:000356551000011
  • scopus:84929321647
ISSN
0166-4328
DOI
10.1016/j.bbr.2015.04.037
language
English
LU publication?
yes
id
08e7aab4-cd69-4858-9bb2-2030558ef7fc (old id 5461361)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25934488?dopt=Abstract
date added to LUP
2015-06-04 12:56:57
date last changed
2017-07-30 03:11:30
@article{08e7aab4-cd69-4858-9bb2-2030558ef7fc,
  abstract     = {Research aimed at developing new therapies for Parkinson's disease (PD) critically depend on valid animal models of the disease that allows for repeated testing of motor disabilities over extended time periods. We here present an extensive characterization of a wide range of motor symptoms in the 6-OHDA marmoset model of PD when tested over several months. The severity of motor deficits was quantified in two ways: (i) through manual scoring protocols appropriately adapted to include species specific motor behavior and (ii) using automated quantitative motion tracking based on image processing of the digital video recordings. We show that the automated methods allow for rapid and reliable characterization of motor dysfunctions, thus complementing the manual scoring procedures, and that robust motor symptoms lasting for several months could be induced when using a two-stage neurotoxic lesioning procedure involving one hemisphere at a time. This non-human primate model of PD should therefore be well suited for long-term evaluation of novel therapies for treatment of PD.},
  author       = {Santana, M and Palmér, Tobias and Simplício, H and Fuentes, R and Petersson, Per},
  issn         = {0166-4328},
  language     = {eng},
  pages        = {90--101},
  publisher    = {Elsevier},
  series       = {Behavioural Brain Research},
  title        = {Characterization of long-term motor deficits in the 6-OHDA model of Parkinson's disease in the common marmoset.},
  url          = {http://dx.doi.org/10.1016/j.bbr.2015.04.037},
  volume       = {290},
  year         = {2015},
}