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An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.

Blein, Sophie; Bardel, Claire; Danjean, Vincent; McGuffog, Lesley; Healey, Sue; Barrowdale, Daniel; Lee, Andrew; Dennis, Joe; Kuchenbaecker, Karoline B and Soucy, Penny, et al. (2015) In Breast Cancer Research 17(1).
Abstract
Individuals carrying pathogenic mutations in BRCA1/2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals from different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. Here we test the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers.
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Breast Cancer Research
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17
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1
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BioMed Central
external identifiers
  • pmid:25925750
  • wos:000356773600001
  • scopus:84932607033
ISSN
1465-5411
DOI
10.1186/s13058-015-0567-2
language
English
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yes
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b451bc25-c056-4853-b75f-b051f06eb29e (old id 5461561)
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http://www.ncbi.nlm.nih.gov/pubmed/25925750?dopt=Abstract
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2015-06-06 12:57:56
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2017-09-03 03:28:37
@article{b451bc25-c056-4853-b75f-b051f06eb29e,
  abstract     = {Individuals carrying pathogenic mutations in BRCA1/2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals from different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. Here we test the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers.},
  articleno    = {61},
  author       = {Blein, Sophie and Bardel, Claire and Danjean, Vincent and McGuffog, Lesley and Healey, Sue and Barrowdale, Daniel and Lee, Andrew and Dennis, Joe and Kuchenbaecker, Karoline B and Soucy, Penny and Terry, Mary Beth and Chung, Wendy K and Goldgar, David E and Buys, Saundra S and Janavicius, Ramunas and Tihomirova, Laima and Tung, Nadine and Dorfling, Cecilia M and van Rensburg, Elizabeth J and Neuhausen, Susan L and Ding, Yuan Chun and Gerdes, Anne-Marie and Ejlertsen, Bent and Nielsen, Finn C and Hansen, Thomas Vo and Osorio, Ana and Benitez, Javier and Andrés-Conejero, Raquel and Segota, Ena and Weitzel, Jeffrey N and Thelander, Margo and Peterlongo, Paolo and Radice, Paolo and Pensotti, Valeria and Dolcetti, Riccardo and Bonanni, Bernardo and Peissel, Bernard and Zaffaroni, Daniela and Scuvera, Giulietta and Manoukian, Siranoush and Varesco, Liliana and Capone, Gabriele L and Papi, Laura and Ottini, Laura and Yannoukakos, Drakoulis and Konstantopoulou, Irene and Garber, Judy and Hamann, Ute and Donaldson, Alan and Brady, Angela and Brewer, Carole and Foo, Claire and Evans, D Gareth and Frost, Debra and Eccles, Diana and Douglas, Fiona and Cook, Jackie and Adlard, Julian and Barwell, Julian and Walker, Lisa and Izatt, Louise and Side, Lucy E and Kennedy, M John and Tischkowitz, Marc and Rogers, Mark T and Porteous, Mary E and Morrison, Patrick J and Platte, Radka and Eeles, Ros and Davidson, Rosemarie and Hodgson, Shirley and Cole, Trevor and Godwin, Andrew K and Isaacs, Claudine and Claes, Kathleen and De Leeneer, Kim and Meindl, Alfons and Gehrig, Andrea and Wappenschmidt, Barbara and Sutter, Christian and Engel, Christoph and Niederacher, Dieter and Steinemann, Doris and Plendl, Hansjoerg and Kast, Karin and Rhiem, Kerstin and Ditsch, Nina and Arnold, Norbert and Varon-Mateeva, Raymonda and Schmutzler, Rita K and Preisler-Adams, Sabine and Markov, Nadja Bogdanova and Wang-Gohrke, Shan and de Pauw, Antoine and Lefol, Cédrick and Lasset, Christine and Leroux, Dominique and Rouleau, Etienne and Damiola, Francesca and Dreyfus, Hélène and Barjhoux, Laure and Golmard, Lisa and Uhrhammer, Nancy and Bonadona, Valérie and Sornin, Valérie and Bignon, Yves-Jean and Carter, Jonathan and Van Le, Linda and Piedmonte, Marion and DiSilvestro, Paul A and de la Hoya, Miguel and Caldes, Trinidad and Nevanlinna, Heli and Aittomäki, Kristiina and Jager, Agnes and van den Ouweland, Ans Mw and Kets, Carolien M and Aalfs, Cora M and van Leeuwen, Flora E and Hogervorst, Frans Bl and Meijers-Heijboer, Hanne Ej and Oosterwijk, Jan C and van Roozendaal, Kees Ep and Rookus, Matti A and Devilee, Peter and van der Luijt, Rob B and Olah, Edith and Diez, Orland and Teulé, Alex and Lazaro, Conxi and Blanco, Ignacio and Del Valle, Jesús and Jakubowska, Anna and Sukiennicki, Grzegorz and Gronwald, Jacek and Lubinski, Jan and Durda, Katarzyna and Jaworska-Bieniek, Katarzyna and Agnarsson, Bjarni A and Maugard, Christine and Amadori, Alberto and Montagna, Marco and Teixeira, Manuel R and Spurdle, Amanda B and Foulkes, William and Olswold, Curtis and Lindor, Noralane and Pankratz, Vernon S and Szabo, Csilla I and Lincoln, Anne and Jacobs, Lauren and Corines, Marina and Robson, Mark and Vijai, Joseph and Berger, Andreas and Fink-Retter, Anneliese and Singer, Christian F and Rappaport, Christine and Kaulich, Daphne Geschwantler and Pfeiler, Georg and Tea, Muy-Kheng and Greene, Mark H and Mai, Phuong L and Rennert, Gad and Imyanitov, Evgeny N and Mulligan, Anna Marie and Glendon, Gord and Andrulis, Irene L and Tchatchou, Sandrine and Toland, Amanda Ewart and Pedersen, Inge Sokilde and Thomassen, Mads and Kruse, Torben A and Jensen, Uffe Birk and Caligo, Maria A and Friedman, Eitan and Zidan, Jamal and Laitman, Yael and Lindblom, Annika and Melin, Beatrice and Arver, Brita and Loman, Niklas and Rosenquist, Richard and Olopade, Olufunmilayo I and Nussbaum, Robert L and Ramus, Susan J and Nathanson, Katherine L and Domchek, Susan M and Rebbeck, Timothy R and Arun, Banu K and Mitchell, Gillian and Karlan, Beth Y and Lester, Jenny and Orsulic, Sandra and Stoppa-Lyonnet, Dominique and Thomas, Gilles and Simard, Jacques and Couch, Fergus J and Offit, Kenneth and Easton, Douglas F and Chenevix-Trench, Georgia and Antoniou, Antonis C and Mazoyer, Sylvie and Phelan, Catherine M and Sinilnikova, Olga M and Cox, David G},
  issn         = {1465-5411},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Breast Cancer Research},
  title        = {An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.},
  url          = {http://dx.doi.org/10.1186/s13058-015-0567-2},
  volume       = {17},
  year         = {2015},
}