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Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging

Wisse, Laura E M LU orcid ; Biessels, Geert Jan ; Heringa, Sophie M ; Kuijf, Hugo J ; Koek, Dineke H L ; Luijten, Peter R and Geerlings, Mirjam I (2014) In Neurobiology of Aging 35(9). p.45-2039
Abstract

We compared hippocampal subfield and entorhinal cortex (ERC) volumes between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls without cognitive impairment. Additionally, we investigated the relation between age and hippocampal subfields and ERC in controls. We performed ultra-high field 0.7 mm(3) 7Tesla magnetic resonance imaging in 16 patients with amnestic MCI, 9 with AD, and 29 controls. ERC, subiculum, cornu ammonis (CA)1, CA2, CA3, and dentate gyrus (DG)&CA4 were traced on T2-weighted images. Analyses of covariance, adjusted for age, sex, and intracranial volume showed that compared with controls and patients with MCI, patients with AD had significantly smaller ERC, subiculum, CA1, CA3, and... (More)

We compared hippocampal subfield and entorhinal cortex (ERC) volumes between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls without cognitive impairment. Additionally, we investigated the relation between age and hippocampal subfields and ERC in controls. We performed ultra-high field 0.7 mm(3) 7Tesla magnetic resonance imaging in 16 patients with amnestic MCI, 9 with AD, and 29 controls. ERC, subiculum, cornu ammonis (CA)1, CA2, CA3, and dentate gyrus (DG)&CA4 were traced on T2-weighted images. Analyses of covariance, adjusted for age, sex, and intracranial volume showed that compared with controls and patients with MCI, patients with AD had significantly smaller ERC, subiculum, CA1, CA3, and DG&CA4 volumes. Trend analyses revealed similar associations between ERC and hippocampal subfields and diagnostic group. Older age was significantly associated with smaller CA1 and DG&CA4 volumes. In conclusion, almost all hippocampal subfields and ERC show volume reductions in patients with AD compared with controls and patients with MCI. Future, larger studies should determine which subfields are affected earliest in the disease process and what mechanisms underlie the volume loss.

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author collaboration
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Aged, 80 and over, Aging/pathology, Alzheimer Disease/pathology, CA1 Region, Hippocampal/pathology, CA2 Region, Hippocampal/pathology, CA3 Region, Hippocampal/pathology, Cognitive Dysfunction/pathology, Dentate Gyrus/pathology, Diffusion Magnetic Resonance Imaging, Entorhinal Cortex/pathology, Female, Humans, Male, Organ Size
in
Neurobiology of Aging
volume
35
issue
9
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:84902073705
  • pmid:24684788
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2014.02.021
language
English
LU publication?
no
additional info
Copyright © 2014 Elsevier Inc. All rights reserved.
id
54664d77-01cb-4e9b-b949-f203bac1bc6c
date added to LUP
2024-02-28 15:03:43
date last changed
2025-06-23 17:27:44
@article{54664d77-01cb-4e9b-b949-f203bac1bc6c,
  abstract     = {{<p>We compared hippocampal subfield and entorhinal cortex (ERC) volumes between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls without cognitive impairment. Additionally, we investigated the relation between age and hippocampal subfields and ERC in controls. We performed ultra-high field 0.7 mm(3) 7Tesla magnetic resonance imaging in 16 patients with amnestic MCI, 9 with AD, and 29 controls. ERC, subiculum, cornu ammonis (CA)1, CA2, CA3, and dentate gyrus (DG)&amp;CA4 were traced on T2-weighted images. Analyses of covariance, adjusted for age, sex, and intracranial volume showed that compared with controls and patients with MCI, patients with AD had significantly smaller ERC, subiculum, CA1, CA3, and DG&amp;CA4 volumes. Trend analyses revealed similar associations between ERC and hippocampal subfields and diagnostic group. Older age was significantly associated with smaller CA1 and DG&amp;CA4 volumes. In conclusion, almost all hippocampal subfields and ERC show volume reductions in patients with AD compared with controls and patients with MCI. Future, larger studies should determine which subfields are affected earliest in the disease process and what mechanisms underlie the volume loss.</p>}},
  author       = {{Wisse, Laura E M and Biessels, Geert Jan and Heringa, Sophie M and Kuijf, Hugo J and Koek, Dineke H L and Luijten, Peter R and Geerlings, Mirjam I}},
  issn         = {{1558-1497}},
  keywords     = {{Aged; Aged, 80 and over; Aging/pathology; Alzheimer Disease/pathology; CA1 Region, Hippocampal/pathology; CA2 Region, Hippocampal/pathology; CA3 Region, Hippocampal/pathology; Cognitive Dysfunction/pathology; Dentate Gyrus/pathology; Diffusion Magnetic Resonance Imaging; Entorhinal Cortex/pathology; Female; Humans; Male; Organ Size}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{45--2039}},
  publisher    = {{Elsevier}},
  series       = {{Neurobiology of Aging}},
  title        = {{Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging}},
  url          = {{http://dx.doi.org/10.1016/j.neurobiolaging.2014.02.021}},
  doi          = {{10.1016/j.neurobiolaging.2014.02.021}},
  volume       = {{35}},
  year         = {{2014}},
}