Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia

Vikman, Petter LU (2006)
Abstract
The thesis consideres the molecular events that take place in the cerebral arteries following a stroke. The degree and temporal course of reperfusion following a stroke is pivotal for the survival of the neuronal tissue in the penumbra. Previous investigations have revealed upregulation of contractile receptors, a putative factor in the blood flow reduction following stroke that can could augment cell death. The major aim of the study is achieve a better understanding of the changes that occur in the cerebral arteries following a stroke and of the resulting activation of the signal pathways involved, along with changes in gene expression and protein regulation to further the knowledge of how arteries participate in the events that take... (More)
The thesis consideres the molecular events that take place in the cerebral arteries following a stroke. The degree and temporal course of reperfusion following a stroke is pivotal for the survival of the neuronal tissue in the penumbra. Previous investigations have revealed upregulation of contractile receptors, a putative factor in the blood flow reduction following stroke that can could augment cell death. The major aim of the study is achieve a better understanding of the changes that occur in the cerebral arteries following a stroke and of the resulting activation of the signal pathways involved, along with changes in gene expression and protein regulation to further the knowledge of how arteries participate in the events that take place following a stroke.



The more specific goals have been the following:



* To investigate the gene regulation in cerebral arteries following SAH, aimed at determining what the important processes involved in the increase in contraction are.



* Investigation of MAPK activation and its relation to gene expression.



* Comparison of the ischemic models MCAO and SAH with organ culture of cerebral arteries to determine similarities and to validate the use of organ culture as a model.



* Investigation of gene expression and protein regulation in human MCA following thromboembolic stroke so as validate previous findings in connection with experimental rat models.



* Molecular characterization of smoke induced changes in cerebral arteries. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • BSc, PhD Kelly, Paul, Western General Hospital, Edinburgh
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Naturvetenskap, Cardiovascular system, stroke, molecular investigation, gene expression, Mitogen Activated Protein Kinases, Natural science, Kardiovaskulära systemet, cerebral arteries
pages
57 pages
publisher
Experimental Vascular Research
defense location
Segerfalk salen BMC
defense date
2006-06-16 09:00:00
ISBN
91-85559-11-3
language
English
LU publication?
yes
additional info
P Vikman, S Beg, T Khurana, J Hansen-Schwartz and L Edvinsson. 2006. Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in rat. Journal of Neurosurgery, (accepted)
P Vikman and L Edvinsson. 2006. Gene expression profiling in the human middle cerebral artery after cerebral ischemia. European Journal of Neurology, (accepted)
P Vikman, S Beg, M Henriksson and L Edvinsson. 2006. Activation of p38, ERK1/2 and SAPK/JNK initiate transcription of inflammatory and extracellular matrix genes in cerebral arteries following cerebral ischemia in rat. (submitted)
P Vikman, S Beg and L Edvinsson. 2006. Signal transduction, inflammation and gene activation in cerebral arteries following experimental SAH in rat. (submitted)
P Vikman and L Edvinsson. 2006. Lipid soluble smoking particles induce an inflammatory response in rat cerebral arteries via p38MAPK activation and downstream transcription factors ATF-2 and Elk-1. (submitted)
id
ab94bfd5-fe3a-4b6f-be79-583558d4f54a (old id 547010)
date added to LUP
2016-04-01 15:45:57
date last changed
2018-11-21 20:36:11
@phdthesis{ab94bfd5-fe3a-4b6f-be79-583558d4f54a,
  abstract     = {{The thesis consideres the molecular events that take place in the cerebral arteries following a stroke. The degree and temporal course of reperfusion following a stroke is pivotal for the survival of the neuronal tissue in the penumbra. Previous investigations have revealed upregulation of contractile receptors, a putative factor in the blood flow reduction following stroke that can could augment cell death. The major aim of the study is achieve a better understanding of the changes that occur in the cerebral arteries following a stroke and of the resulting activation of the signal pathways involved, along with changes in gene expression and protein regulation to further the knowledge of how arteries participate in the events that take place following a stroke.<br/><br>
<br/><br>
The more specific goals have been the following:<br/><br>
<br/><br>
* To investigate the gene regulation in cerebral arteries following SAH, aimed at determining what the important processes involved in the increase in contraction are.<br/><br>
<br/><br>
* Investigation of MAPK activation and its relation to gene expression.<br/><br>
<br/><br>
* Comparison of the ischemic models MCAO and SAH with organ culture of cerebral arteries to determine similarities and to validate the use of organ culture as a model.<br/><br>
<br/><br>
* Investigation of gene expression and protein regulation in human MCA following thromboembolic stroke so as validate previous findings in connection with experimental rat models.<br/><br>
<br/><br>
* Molecular characterization of smoke induced changes in cerebral arteries.}},
  author       = {{Vikman, Petter}},
  isbn         = {{91-85559-11-3}},
  keywords     = {{Naturvetenskap; Cardiovascular system; stroke; molecular investigation; gene expression; Mitogen Activated Protein Kinases; Natural science; Kardiovaskulära systemet; cerebral arteries}},
  language     = {{eng}},
  publisher    = {{Experimental Vascular Research}},
  school       = {{Lund University}},
  title        = {{Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia}},
  url          = {{https://lup.lub.lu.se/search/files/4465581/547012.pdf}},
  year         = {{2006}},
}