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BIOACTIVE SECONDARY METABOLITES -Isolation Characterization and Synthesis

Valdivia, Carola LU (2006)
Abstract
Nature produces biologically active and chemically intriguing secondary metabolites. To isolate and characterize compounds of novel activity and structure, bioassay-guided fractionations were applied to several plants as well as to a basidiomycete. Our studies resulted in the purification and characterization of a diverse range of compounds displaying activity in a variety of biological assays. New secondary metabolites and semi-synthetic compounds were obtained from Bolivian species Piper heterophyllum, Piper obliquum, Piper longestylosum and Baccharis genistelloides, from the European species Myrtus communis, Thapsia garganica and from the basidiomycete Coprinus heptemerus.
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Professor Björk, Lars, Institutionen för evolution, genomik och systematik, Systematisk botanik
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Organisk kemi, Organic chemistry, Baccharis genistelloides, Piper heterophyllum, Myrtus Communis, Coprinus heptemerus, Thapsia garganica, Piper longestylosum, Piper obliquum, Natural Products
pages
141 pages
publisher
Organic Chemistry, Lund University
defense location
Kemicentrum, sal K:G, Lunds Tekniska Högskola
defense date
2006-08-18 09:30:00
ISBN
91-628-6881-0
language
English
LU publication?
yes
additional info
Giovanni Appendino, Lucia Maxia, Piergiorgio Bettoni, Monica Locatelli, Carola Valdivia, Mauro Ballero, Michael Stavri, Simon Gibbons and Olov Sterner. 2006. Antibacterial Galloylated Alkylphloroglucinol Glucides from Myrtle (Myrtus communis) Journal of Natural products, vol 69 pp 67-70. Media-Tryck
Giovanni Appendino, Simona Prosperini, Carola Valdivia, Mauro Ballero, Giampiero Colombano, Richard Billington, Armando Genazzani and Olov Sterner. 2005. SERCA-Inhibiting Activity of C-19 Terpenolides from Thapsia garganica and their possible biogenesis Journal of natural products, vol 68 pp 71-75. Media-Tryck
. 2005. SERCA-Inhibiting Activity of C-19 Terpenolides from Thapsia garganica and their Possible Biogenesis Journal of Natural Products, vol 68 pp 71-75. Media-Tryck
Carola Valdivia. 2005. Diterpenoid from Coprinus heptemerus Tetrahedron, pp 77-82. Media-Tryck
Carola Valdivia, Patricia Mollinedo, Antonio Vilaseca and Olov Sterner. . Prenylated protocatechuic acid derivatives with antioxidant activity from Piper heterophyllum (manuscript)
Carola Valdivia, John Eriksson, Antonio Vilaseca and Olov Sterner. . Alkenylphenols and a new 4-chromanone derivative from Piper obliquum (manuscript)
Carola Valdivia, Antonio Vilaseca and Olov Sterner. . Benzoic acid derivatives from piper longestylosum (manuscript)
Carola Valdivia, Åke Boketof, Björn Olde, Christer Owman, Antonio Vilaseca, Lenny Fuentes and Olov Sterner. . Activation of the free fatty acid receptor GPR40 by (+)-curcuphenol and related synthetic compounds (manuscript)
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
87a8e484-9733-4aeb-95e8-750b916c0765 (old id 547015)
date added to LUP
2016-04-04 11:59:53
date last changed
2018-11-21 21:08:25
@phdthesis{87a8e484-9733-4aeb-95e8-750b916c0765,
  abstract     = {{Nature produces biologically active and chemically intriguing secondary metabolites. To isolate and characterize compounds of novel activity and structure, bioassay-guided fractionations were applied to several plants as well as to a basidiomycete. Our studies resulted in the purification and characterization of a diverse range of compounds displaying activity in a variety of biological assays. New secondary metabolites and semi-synthetic compounds were obtained from Bolivian species Piper heterophyllum, Piper obliquum, Piper longestylosum and Baccharis genistelloides, from the European species Myrtus communis, Thapsia garganica and from the basidiomycete Coprinus heptemerus.}},
  author       = {{Valdivia, Carola}},
  isbn         = {{91-628-6881-0}},
  keywords     = {{Organisk kemi; Organic chemistry; Baccharis genistelloides; Piper heterophyllum; Myrtus Communis; Coprinus heptemerus; Thapsia garganica; Piper longestylosum; Piper obliquum; Natural Products}},
  language     = {{eng}},
  publisher    = {{Organic Chemistry, Lund University}},
  school       = {{Lund University}},
  title        = {{BIOACTIVE SECONDARY METABOLITES -Isolation Characterization and Synthesis}},
  year         = {{2006}},
}