Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Tissue specific functions of Early B-cell factor in cellular differentiation.

Lagergren, Anna LU (2006)
Abstract
This work focus on the functions by which the transcription factor Early B-cell Factor (EBF) regulate gene expression in different cell types. To address this question, gene expression analyses aimed to investigate the regulatory role of EBF in neuroblastoma cells, B-lymphocytes, adipocytes and stromal cells were performed.



The addresses question is of crucial importantse for the understanding of basic concepts in the area of developmental biology, were a limited set of transcription factors are able to support the development of different cell types. This could be achieved by that different differentiation-pathways share vital target genes involved in differentiation in general, or that TFs act on different target genes... (More)
This work focus on the functions by which the transcription factor Early B-cell Factor (EBF) regulate gene expression in different cell types. To address this question, gene expression analyses aimed to investigate the regulatory role of EBF in neuroblastoma cells, B-lymphocytes, adipocytes and stromal cells were performed.



The addresses question is of crucial importantse for the understanding of basic concepts in the area of developmental biology, were a limited set of transcription factors are able to support the development of different cell types. This could be achieved by that different differentiation-pathways share vital target genes involved in differentiation in general, or that TFs act on different target genes in different tissues. This work strongly suggests that in the case of EBF, it is an issue of regulation of different target genes in different tissues. The work indicates that the mechanism by which this is achieved would be a combination of coordinated expression of co-factors and chromatin configuration. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Professor Rothenberg, Ellen, California Institute of Technology, Pasadena, CA
organization
publishing date
type
Thesis
publication status
published
subject
keywords
transcription factor, extracellular fluids, Haematology, tissue specific, cellular differentiation, EBF, Hematologi, extracellulära vätskor
pages
57 pages
publisher
Lund Strategic Research Center for Stem Cell Biology and Cell Therapy
defense location
Segerfalk lecture hall Wallenberg Neurosciense Center, Sölvegatan 19, Lund
defense date
2006-10-02 13:00:00
ISBN
91-85559-25-3
language
English
LU publication?
yes
additional info
Anna Lagergren, Christina Manetopoulos, Håkan Axelson and Mikael Sigvardsson. 2004. Neuroblastoma and pre-B lymphoma cells share expression of key transcription factors but display tissue restricted target gene expression. BMC Cancer, vol 4
Robert Månsson, Panagiotis Tsapogas, Mikael Åkerlund, Anna Lagergren, Ramiro Gisler and Mikael Sigvardsson. 2004. Pearson correlation analysis of microarray data allows for the identification of genetic targets for Early B-cell Factor. Journal of Biological Chemistry, vol 279 pp 17905-17913.
Anna Lagergren, Robert Månsson, Emma Smith, Barbro Basta, David Bryder, Peter Åkerblad and Mikael Sigvardsson. . Early B-cell Factor regulates the expression of B-lineage growth factors in stromacells. (submitted)
Peter Åkerblad, Robert Månsson, Anna Lagergren, Simonetta Westerlund, Barbro Basta, Ulrika Lind, Anders Thelin, Ramiro Gisler, David Liberg, Sven Nelander, Krister Bamberg and Mikael Sigvardsson. 2005. Gene expression analysis suggests that EBF-1 and PPAR?2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics. Physiological Genomics, vol 23 pp 206-216.
Anna Lagergren, Robert Månsson, Frida Hansson, Simonetta Westerlund, Krister Bamberg, Evan Rosen, Mikael Sigvardsson and Peter Åkerblad. . EBF (O/E)-1 is a positive regulator of the IGFII and Glut-4 genes and stimulates adipogenic conversion of NIH3T3 cells with a reduced insulin dependency. (manuscript)
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)
id
c579c56e-ed58-4712-aad9-2e8e1443bc3b (old id 547144)
date added to LUP
2016-04-01 16:50:17
date last changed
2018-11-21 20:44:36
@phdthesis{c579c56e-ed58-4712-aad9-2e8e1443bc3b,
  abstract     = {{This work focus on the functions by which the transcription factor Early B-cell Factor (EBF) regulate gene expression in different cell types. To address this question, gene expression analyses aimed to investigate the regulatory role of EBF in neuroblastoma cells, B-lymphocytes, adipocytes and stromal cells were performed.<br/><br>
<br/><br>
The addresses question is of crucial importantse for the understanding of basic concepts in the area of developmental biology, were a limited set of transcription factors are able to support the development of different cell types. This could be achieved by that different differentiation-pathways share vital target genes involved in differentiation in general, or that TFs act on different target genes in different tissues. This work strongly suggests that in the case of EBF, it is an issue of regulation of different target genes in different tissues. The work indicates that the mechanism by which this is achieved would be a combination of coordinated expression of co-factors and chromatin configuration.}},
  author       = {{Lagergren, Anna}},
  isbn         = {{91-85559-25-3}},
  keywords     = {{transcription factor; extracellular fluids; Haematology; tissue specific; cellular differentiation; EBF; Hematologi; extracellulära vätskor}},
  language     = {{eng}},
  publisher    = {{Lund Strategic Research Center for Stem Cell Biology and Cell Therapy}},
  school       = {{Lund University}},
  title        = {{Tissue specific functions of Early B-cell factor in cellular differentiation.}},
  year         = {{2006}},
}