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Tissue specific functions of Early B-cell factor in cellular differentiation.

Lagergren, Anna LU (2006)
Abstract
This work focus on the functions by which the transcription factor Early B-cell Factor (EBF) regulate gene expression in different cell types. To address this question, gene expression analyses aimed to investigate the regulatory role of EBF in neuroblastoma cells, B-lymphocytes, adipocytes and stromal cells were performed.



The addresses question is of crucial importantse for the understanding of basic concepts in the area of developmental biology, were a limited set of transcription factors are able to support the development of different cell types. This could be achieved by that different differentiation-pathways share vital target genes involved in differentiation in general, or that TFs act on different target genes... (More)
This work focus on the functions by which the transcription factor Early B-cell Factor (EBF) regulate gene expression in different cell types. To address this question, gene expression analyses aimed to investigate the regulatory role of EBF in neuroblastoma cells, B-lymphocytes, adipocytes and stromal cells were performed.



The addresses question is of crucial importantse for the understanding of basic concepts in the area of developmental biology, were a limited set of transcription factors are able to support the development of different cell types. This could be achieved by that different differentiation-pathways share vital target genes involved in differentiation in general, or that TFs act on different target genes in different tissues. This work strongly suggests that in the case of EBF, it is an issue of regulation of different target genes in different tissues. The work indicates that the mechanism by which this is achieved would be a combination of coordinated expression of co-factors and chromatin configuration. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Professor Rothenberg, Ellen, California Institute of Technology, Pasadena, CA
organization
publishing date
type
Thesis
publication status
published
subject
keywords
transcription factor, extracellular fluids, Haematology, tissue specific, cellular differentiation, EBF, Hematologi, extracellulära vätskor
pages
57 pages
publisher
Lund Strategic Research Center for Stem Cell Biology and Cell Therapy
defense location
Segerfalk lecture hall Wallenberg Neurosciense Center, Sölvegatan 19, Lund
defense date
2006-10-02 13:00:00
ISBN
91-85559-25-3
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)
id
c579c56e-ed58-4712-aad9-2e8e1443bc3b (old id 547144)
date added to LUP
2016-04-01 16:50:17
date last changed
2018-11-21 20:44:36
@phdthesis{c579c56e-ed58-4712-aad9-2e8e1443bc3b,
  abstract     = {This work focus on the functions by which the transcription factor Early B-cell Factor (EBF) regulate gene expression in different cell types. To address this question, gene expression analyses aimed to investigate the regulatory role of EBF in neuroblastoma cells, B-lymphocytes, adipocytes and stromal cells were performed.<br/><br>
<br/><br>
The addresses question is of crucial importantse for the understanding of basic concepts in the area of developmental biology, were a limited set of transcription factors are able to support the development of different cell types. This could be achieved by that different differentiation-pathways share vital target genes involved in differentiation in general, or that TFs act on different target genes in different tissues. This work strongly suggests that in the case of EBF, it is an issue of regulation of different target genes in different tissues. The work indicates that the mechanism by which this is achieved would be a combination of coordinated expression of co-factors and chromatin configuration.},
  author       = {Lagergren, Anna},
  isbn         = {91-85559-25-3},
  language     = {eng},
  publisher    = {Lund Strategic Research Center for Stem Cell Biology and Cell Therapy},
  school       = {Lund University},
  title        = {Tissue specific functions of Early B-cell factor in cellular differentiation.},
  year         = {2006},
}