Resistance to phagocytosis in Streptococcus pyogenes
(2005) In Lund University Faculty of Medicine Doctoral Dissertation Series 83,5638888888889.- Abstract
- Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. To analyze the mechanisms by which M protein confers this ability we used, as model systems, two representative M proteins, the M22 and M5 proteins, which have properties typical for many M proteins of different M type.
- Abstract (Swedish)
- Popular Abstract in Swedish
Denna avhandling beskriver studier av de mekanismer varmed bakterien Streptococcus pyogenes undviker komplementdeposition och fagocytos.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/547386
- author
- Carlsson, Fredric LU
- supervisor
- opponent
-
- professor Wessels, Michael R., Harvad Medical School
- organization
- publishing date
- 2005
- type
- Thesis
- publication status
- published
- subject
- keywords
- Infektioner, Infections, Medicine (human and vertebrates), Medicin (människa och djur), phagocytosis, innate immunity, complement, Streptococcus pyogenes, M protein
- in
- Lund University Faculty of Medicine Doctoral Dissertation Series
- volume
- 83,5638888888889
- publisher
- Department of Laboratory Medicine, Lund University
- defense location
- Segerfalkssalen
- defense date
- 2005-05-21 09:30:00
- ISSN
- 1652-8220
- ISBN
- 91-85439-38-X
- language
- English
- LU publication?
- yes
- additional info
- F Carlsson, K Berggård, M Stålhammar-Carlemalm and G Lindahl. 2003. Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein. J Exp Med, vol 198 pp 1057-1068.F Carlsson, C Sandin and G Lindahl. 2005. Human fibrinogen bound to Streptococcus pyogenes M protein inhibits complement deposition via the classical pathway. Mol Microbiol., vol 56 pp 28-39.
- id
- 26af57a6-2f5c-498c-a9a6-b3f047130304 (old id 547386)
- date added to LUP
- 2016-04-01 16:14:29
- date last changed
- 2019-05-22 05:57:57
@phdthesis{26af57a6-2f5c-498c-a9a6-b3f047130304, abstract = {{Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. To analyze the mechanisms by which M protein confers this ability we used, as model systems, two representative M proteins, the M22 and M5 proteins, which have properties typical for many M proteins of different M type.}}, author = {{Carlsson, Fredric}}, isbn = {{91-85439-38-X}}, issn = {{1652-8220}}, keywords = {{Infektioner; Infections; Medicine (human and vertebrates); Medicin (människa och djur); phagocytosis; innate immunity; complement; Streptococcus pyogenes; M protein}}, language = {{eng}}, publisher = {{Department of Laboratory Medicine, Lund University}}, school = {{Lund University}}, series = {{Lund University Faculty of Medicine Doctoral Dissertation Series}}, title = {{Resistance to phagocytosis in Streptococcus pyogenes}}, volume = {{83,5638888888889}}, year = {{2005}}, }