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Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression

Gonzales, Mitzi M.; Insel, Philip S. LU ; Nelson, Craig; Tosun, Duygu; Mattsson, Niklas LU ; Mueller, Susanne G.; Sacuiu, Simona; Bickford, David; Weiner, Michael W and Mackin, R Scott, et al. (2017) In American Journal of Geriatric Psychiatry 25(9). p.980-991
Abstract

Objectives: To investigate the association between cognitive decline and cortical atrophy in individuals with mild cognitive impairment (MCI) and chronic subsyndromal symptoms of depression (SSD) over a 4-year period. Design: Prospective cohort study. Setting: Multicenter, clinic-based. Participants: Within the Alzheimer's Disease Neuroimaging Initiative repository, the Neuropsychiatric Inventory was used to identify individuals with MCI and stable endorsement (SSD group N = 32) or no endorsement (non-SSD group N = 69) of depressive symptoms across time points. Measurements: Repeated measures of cognitive outcomes, cortical atrophy, and their associations were evaluated with mixed effects models adjusting for age, education, sex, and... (More)

Objectives: To investigate the association between cognitive decline and cortical atrophy in individuals with mild cognitive impairment (MCI) and chronic subsyndromal symptoms of depression (SSD) over a 4-year period. Design: Prospective cohort study. Setting: Multicenter, clinic-based. Participants: Within the Alzheimer's Disease Neuroimaging Initiative repository, the Neuropsychiatric Inventory was used to identify individuals with MCI and stable endorsement (SSD group N = 32) or no endorsement (non-SSD group N = 69) of depressive symptoms across time points. Measurements: Repeated measures of cognitive outcomes, cortical atrophy, and their associations were evaluated with mixed effects models adjusting for age, education, sex, and APOE genotype. Results: The SSD group demonstrated accelerated decline on measures of global cognition (Alzheimer Disease Assessment Scale; df = 421, t = 2.242, p = 0.025), memory (Wechsler Memory Scale-Revised Logical Memory II; df = 244, t = -2.525, p = 0.011), information processing speed (Trail Making Test Parts A [df = 421, t = 2.376, p = 0.018] and B [df = 421, t = 2.533, p = 0.012]), and semantic fluency (Category Fluency; df = 424, t = -2.418, p = 0.016), as well as accelerated frontal lobe (df = 341, t = -2.648, p = 0.008) and anterior cingulate (df = 341, t = -3.786, p < 0.001) atrophy. No group differenceswere observed for rate of decline on measures of attention, learning, and confrontation naming or for rate of atrophy in any other regions. Accelerated frontal lobe and anterior cingulate atrophy was associated with cognitive decline on measures of global cognition, information processing speed, and semantic fluency (all p < 0.05), but not memory. Conclusions: Individuals with chronic SSD may represent an MCI subgroup that is highly vulnerable to accelerated cognitive decline, an effect that may be governed by frontal lobe and anterior cingulate atrophy.

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publication status
published
subject
keywords
Anterior cingulate, Cognitive decline, Cortical atrophy, Depressive symptoms, Frontal lobe, Mild cognitive impairment
in
American Journal of Geriatric Psychiatry
volume
25
issue
9
pages
980 - 991
publisher
Elsevier
external identifiers
  • scopus:85020804870
ISSN
1064-7481
DOI
10.1016/j.jagp.2017.04.011
language
English
LU publication?
yes
id
54840dc0-2c09-431a-a5ac-954ca6ebdff4
date added to LUP
2017-08-18 09:32:39
date last changed
2017-09-03 05:26:12
@article{54840dc0-2c09-431a-a5ac-954ca6ebdff4,
  abstract     = {<p>Objectives: To investigate the association between cognitive decline and cortical atrophy in individuals with mild cognitive impairment (MCI) and chronic subsyndromal symptoms of depression (SSD) over a 4-year period. Design: Prospective cohort study. Setting: Multicenter, clinic-based. Participants: Within the Alzheimer's Disease Neuroimaging Initiative repository, the Neuropsychiatric Inventory was used to identify individuals with MCI and stable endorsement (SSD group N = 32) or no endorsement (non-SSD group N = 69) of depressive symptoms across time points. Measurements: Repeated measures of cognitive outcomes, cortical atrophy, and their associations were evaluated with mixed effects models adjusting for age, education, sex, and APOE genotype. Results: The SSD group demonstrated accelerated decline on measures of global cognition (Alzheimer Disease Assessment Scale; df = 421, t = 2.242, p = 0.025), memory (Wechsler Memory Scale-Revised Logical Memory II; df = 244, t = -2.525, p = 0.011), information processing speed (Trail Making Test Parts A [df = 421, t = 2.376, p = 0.018] and B [df = 421, t = 2.533, p = 0.012]), and semantic fluency (Category Fluency; df = 424, t = -2.418, p = 0.016), as well as accelerated frontal lobe (df = 341, t = -2.648, p = 0.008) and anterior cingulate (df = 341, t = -3.786, p &lt; 0.001) atrophy. No group differenceswere observed for rate of decline on measures of attention, learning, and confrontation naming or for rate of atrophy in any other regions. Accelerated frontal lobe and anterior cingulate atrophy was associated with cognitive decline on measures of global cognition, information processing speed, and semantic fluency (all p &lt; 0.05), but not memory. Conclusions: Individuals with chronic SSD may represent an MCI subgroup that is highly vulnerable to accelerated cognitive decline, an effect that may be governed by frontal lobe and anterior cingulate atrophy.</p>},
  author       = {Gonzales, Mitzi M. and Insel, Philip S. and Nelson, Craig and Tosun, Duygu and Mattsson, Niklas and Mueller, Susanne G. and Sacuiu, Simona and Bickford, David and Weiner, Michael W and Mackin, R Scott and , },
  issn         = {1064-7481},
  keyword      = {Anterior cingulate,Cognitive decline,Cortical atrophy,Depressive symptoms,Frontal lobe,Mild cognitive impairment},
  language     = {eng},
  number       = {9},
  pages        = {980--991},
  publisher    = {Elsevier},
  series       = {American Journal of Geriatric Psychiatry},
  title        = {Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression},
  url          = {http://dx.doi.org/10.1016/j.jagp.2017.04.011},
  volume       = {25},
  year         = {2017},
}