Anomalous Protein-Protein Interactions in Multivalent Salt Solution
Pasquier, Coralie LU ; Vazdar, Mario ; Forsman, Jan LU ; Jungwirth, Pavel and Lund, Mikael LU
(2017)
In Journal of Physical Chemistry B
121(14).
p.3000-3006
- Abstract
The stability of aqueous protein solutions is strongly affected by multivalent ions, which induce ion-ion correlations beyond the scope of classical mean-field theory. Using all-atom molecular dynamics (MD) and coarse grained Monte Carlo (MC) simulations, we investigate the interaction between a pair of protein molecules in 3:1 electrolyte solution. In agreement with available experimental findings of "reentrant protein condensation", we observe an anomalous trend in the protein-protein potential of mean force with increasing electrolyte concentration in the order: (i) double-layer repulsion, (ii) ion-ion correlation attraction, (iii) overcharge repulsion, and in excess of 1:1 salt, (iv) non Coulombic attraction. To efficiently sample... (More)
The stability of aqueous protein solutions is strongly affected by multivalent ions, which induce ion-ion correlations beyond the scope of classical mean-field theory. Using all-atom molecular dynamics (MD) and coarse grained Monte Carlo (MC) simulations, we investigate the interaction between a pair of protein molecules in 3:1 electrolyte solution. In agreement with available experimental findings of "reentrant protein condensation", we observe an anomalous trend in the protein-protein potential of mean force with increasing electrolyte concentration in the order: (i) double-layer repulsion, (ii) ion-ion correlation attraction, (iii) overcharge repulsion, and in excess of 1:1 salt, (iv) non Coulombic attraction. To efficiently sample configurational space we explore hybrid continuum solvent models, applicable to many-protein systems, where weakly coupled ions are treated implicitly, while strongly coupled ones are treated explicitly. Good agreement is found with the primitive model of electrolytes, as well as with atomic models of protein and solvent.
(Less)
- author
- Pasquier, Coralie
LU
; Vazdar, Mario
; Forsman, Jan
LU
; Jungwirth, Pavel
and Lund, Mikael
LU
- organization
- publishing date
- 2017-04-13
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Physical Chemistry B
- volume
- 121
- issue
- 14
- pages
- 7 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000399435400009
- pmid:28319376
- scopus:85020040861
- ISSN
- 1520-6106
- DOI
- 10.1021/acs.jpcb.7b01051
- language
- English
- LU publication?
- yes
- id
- 5488a1e3-8000-403e-8b6a-7463bf3abe3c
- date added to LUP
- 2017-06-28 15:53:12
- date last changed
- 2025-01-07 16:14:19
@article{5488a1e3-8000-403e-8b6a-7463bf3abe3c,
abstract = {{<p>The stability of aqueous protein solutions is strongly affected by multivalent ions, which induce ion-ion correlations beyond the scope of classical mean-field theory. Using all-atom molecular dynamics (MD) and coarse grained Monte Carlo (MC) simulations, we investigate the interaction between a pair of protein molecules in 3:1 electrolyte solution. In agreement with available experimental findings of "reentrant protein condensation", we observe an anomalous trend in the protein-protein potential of mean force with increasing electrolyte concentration in the order: (i) double-layer repulsion, (ii) ion-ion correlation attraction, (iii) overcharge repulsion, and in excess of 1:1 salt, (iv) non Coulombic attraction. To efficiently sample configurational space we explore hybrid continuum solvent models, applicable to many-protein systems, where weakly coupled ions are treated implicitly, while strongly coupled ones are treated explicitly. Good agreement is found with the primitive model of electrolytes, as well as with atomic models of protein and solvent.</p>}},
author = {{Pasquier, Coralie and Vazdar, Mario and Forsman, Jan and Jungwirth, Pavel and Lund, Mikael}},
issn = {{1520-6106}},
language = {{eng}},
month = {{04}},
number = {{14}},
pages = {{3000--3006}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Journal of Physical Chemistry B}},
title = {{Anomalous Protein-Protein Interactions in Multivalent Salt Solution}},
url = {{https://lup.lub.lu.se/search/files/27802008/pasquier_et_al_protein_multivalents.pdf}},
doi = {{10.1021/acs.jpcb.7b01051}},
volume = {{121}},
year = {{2017}},
}