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Growth patterns and their contributing factors among HIV-exposed uninfected infants

Ndiaye, Aminata ; Suneson, Klara LU ; Njuguna, Irene ; Ambler, Gwen ; Hanke, Tomas ; John-Stewart, Grace ; Jaoko, Walter and Reilly, Marie (2021) In Maternal and Child Nutrition 17(2).
Abstract

With expanded HIV treatment and prevention programmes, most infants born to HIV-positive women are uninfected, but the patterns and determinants of their growth are not well described. This study aimed to assess growth patterns in a cohort of HIV-exposed uninfected (HEU) infants who participated in an experimental HIV vaccine trial and to test for associations with maternal and infant factors, including in-utero exposure to antiretroviral therapy (ART), mode of delivery, exclusive breastfeeding, mother's education and receipt of the vaccine. Infants in the trial were seen at regular clinic visits from birth to 48 weeks of age. From the anthropometric measurements at these visits, weight-for-age z-scores (WAZ), weight-for-length z-scores... (More)

With expanded HIV treatment and prevention programmes, most infants born to HIV-positive women are uninfected, but the patterns and determinants of their growth are not well described. This study aimed to assess growth patterns in a cohort of HIV-exposed uninfected (HEU) infants who participated in an experimental HIV vaccine trial and to test for associations with maternal and infant factors, including in-utero exposure to antiretroviral therapy (ART), mode of delivery, exclusive breastfeeding, mother's education and receipt of the vaccine. Infants in the trial were seen at regular clinic visits from birth to 48 weeks of age. From the anthropometric measurements at these visits, weight-for-age z-scores (WAZ), weight-for-length z-scores (WLZ) and length-for-age z-scores (LAZ) were computed using World Health Organization (WHO) software and reference tables. Growth patterns were investigated with respect to maternal and infant factors, using linear mixed regression models. From 94 infants included at birth, growth data were available for 75.5% at 48 weeks. The determinants of infant growth in this population are multifactorial: infant LAZ during the first year was significantly lower among infants delivered by caesarean section (p = 0.043); both WAZ and LAZ were depressed among infants with longer exposure to maternal ART (WAZ: p = 0.015; LAZ: p < 0.0001) and among infants of mothers with lower educational level (WAZ: p = 0.038; LAZ: p < 0.0001); the effect of maternal education was modified by breastfeeding practice, with no differences seen in exclusively breastfed infants. These findings inform intervention strategies to preserve growth in this vulnerable infant population.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ART, HIV, infant growth, length-for-age, predictors, pregnancy, weight-for-age
in
Maternal and Child Nutrition
volume
17
issue
2
publisher
Wiley-Blackwell
external identifiers
  • pmid:33269548
  • scopus:85096962013
ISSN
1740-8695
DOI
10.1111/mcn.13110
language
English
LU publication?
yes
id
54b9f7e5-3885-4fe9-9eff-493fa1fe4160
date added to LUP
2020-12-14 11:16:18
date last changed
2024-09-05 10:12:03
@article{54b9f7e5-3885-4fe9-9eff-493fa1fe4160,
  abstract     = {{<p>With expanded HIV treatment and prevention programmes, most infants born to HIV-positive women are uninfected, but the patterns and determinants of their growth are not well described. This study aimed to assess growth patterns in a cohort of HIV-exposed uninfected (HEU) infants who participated in an experimental HIV vaccine trial and to test for associations with maternal and infant factors, including in-utero exposure to antiretroviral therapy (ART), mode of delivery, exclusive breastfeeding, mother's education and receipt of the vaccine. Infants in the trial were seen at regular clinic visits from birth to 48 weeks of age. From the anthropometric measurements at these visits, weight-for-age z-scores (WAZ), weight-for-length z-scores (WLZ) and length-for-age z-scores (LAZ) were computed using World Health Organization (WHO) software and reference tables. Growth patterns were investigated with respect to maternal and infant factors, using linear mixed regression models. From 94 infants included at birth, growth data were available for 75.5% at 48 weeks. The determinants of infant growth in this population are multifactorial: infant LAZ during the first year was significantly lower among infants delivered by caesarean section (p = 0.043); both WAZ and LAZ were depressed among infants with longer exposure to maternal ART (WAZ: p = 0.015; LAZ: p &lt; 0.0001) and among infants of mothers with lower educational level (WAZ: p = 0.038; LAZ: p &lt; 0.0001); the effect of maternal education was modified by breastfeeding practice, with no differences seen in exclusively breastfed infants. These findings inform intervention strategies to preserve growth in this vulnerable infant population.</p>}},
  author       = {{Ndiaye, Aminata and Suneson, Klara and Njuguna, Irene and Ambler, Gwen and Hanke, Tomas and John-Stewart, Grace and Jaoko, Walter and Reilly, Marie}},
  issn         = {{1740-8695}},
  keywords     = {{ART; HIV; infant growth; length-for-age; predictors; pregnancy; weight-for-age}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Maternal and Child Nutrition}},
  title        = {{Growth patterns and their contributing factors among HIV-exposed uninfected infants}},
  url          = {{http://dx.doi.org/10.1111/mcn.13110}},
  doi          = {{10.1111/mcn.13110}},
  volume       = {{17}},
  year         = {{2021}},
}