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The Emerging Role of Topical Ocular Drugs to Target the Posterior Eye

Wang, Lixiang ; Zhou, Mikael Ben LU and Zhang, Hui (2021) In Ophthalmology and Therapy 10(3). p.465-494
Abstract

The prevalence of chronic fundus diseases is increasing with the aging of the general population. The treatment of these intraocular diseases relies on invasive drug delivery because of the globular structure and multiple barriers of the eye. Frequent intraocular injections bring heavy burdens to the medical care system and patients. The use of topical drugs to treat retinal diseases has always been an attractive solution. The fast development of new materials and technologies brings the possibility to develop innovative topical formulations. This article reviews anatomical and physiological barriers of the eye which affect the bioavailability of topical drugs. In addition, we summarize innovative topical formulations which enhance the... (More)

The prevalence of chronic fundus diseases is increasing with the aging of the general population. The treatment of these intraocular diseases relies on invasive drug delivery because of the globular structure and multiple barriers of the eye. Frequent intraocular injections bring heavy burdens to the medical care system and patients. The use of topical drugs to treat retinal diseases has always been an attractive solution. The fast development of new materials and technologies brings the possibility to develop innovative topical formulations. This article reviews anatomical and physiological barriers of the eye which affect the bioavailability of topical drugs. In addition, we summarize innovative topical formulations which enhance the permeability of drugs through the ocular surface and/or extend the drug retention time in the eye. This article also reviews the differences of eyes between different laboratory animals to address the translational challenges of preclinical models. The fast development of in vitro eye models may provide more tools to increase the clinical translationality of topical formulations for intraocular diseases. Clinical successes of topical formulations rely on continuous and collaborative efforts between different disciplines.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Comparative anatomy of the eye, In vitro eye model, In vivo eye models, Nanoparticles, Ocular barriers, Ocular drug delivery, Ocular fundus diseases, Topical formulation
in
Ophthalmology and Therapy
volume
10
issue
3
pages
30 pages
publisher
Springer
external identifiers
  • pmid:34218424
  • scopus:85109288078
ISSN
2193-8245
DOI
10.1007/s40123-021-00365-y
language
English
LU publication?
yes
id
5502e5ff-5ceb-4b3e-89f8-a8d49044ccc6
date added to LUP
2021-08-12 14:35:11
date last changed
2022-05-24 07:31:00
@article{5502e5ff-5ceb-4b3e-89f8-a8d49044ccc6,
  abstract     = {{<p>The prevalence of chronic fundus diseases is increasing with the aging of the general population. The treatment of these intraocular diseases relies on invasive drug delivery because of the globular structure and multiple barriers of the eye. Frequent intraocular injections bring heavy burdens to the medical care system and patients. The use of topical drugs to treat retinal diseases has always been an attractive solution. The fast development of new materials and technologies brings the possibility to develop innovative topical formulations. This article reviews anatomical and physiological barriers of the eye which affect the bioavailability of topical drugs. In addition, we summarize innovative topical formulations which enhance the permeability of drugs through the ocular surface and/or extend the drug retention time in the eye. This article also reviews the differences of eyes between different laboratory animals to address the translational challenges of preclinical models. The fast development of in vitro eye models may provide more tools to increase the clinical translationality of topical formulations for intraocular diseases. Clinical successes of topical formulations rely on continuous and collaborative efforts between different disciplines.</p>}},
  author       = {{Wang, Lixiang and Zhou, Mikael Ben and Zhang, Hui}},
  issn         = {{2193-8245}},
  keywords     = {{Comparative anatomy of the eye; In vitro eye model; In vivo eye models; Nanoparticles; Ocular barriers; Ocular drug delivery; Ocular fundus diseases; Topical formulation}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{465--494}},
  publisher    = {{Springer}},
  series       = {{Ophthalmology and Therapy}},
  title        = {{The Emerging Role of Topical Ocular Drugs to Target the Posterior Eye}},
  url          = {{http://dx.doi.org/10.1007/s40123-021-00365-y}},
  doi          = {{10.1007/s40123-021-00365-y}},
  volume       = {{10}},
  year         = {{2021}},
}