The Emerging Role of Topical Ocular Drugs to Target the Posterior Eye
(2021) In Ophthalmology and Therapy 10(3). p.465-494- Abstract
The prevalence of chronic fundus diseases is increasing with the aging of the general population. The treatment of these intraocular diseases relies on invasive drug delivery because of the globular structure and multiple barriers of the eye. Frequent intraocular injections bring heavy burdens to the medical care system and patients. The use of topical drugs to treat retinal diseases has always been an attractive solution. The fast development of new materials and technologies brings the possibility to develop innovative topical formulations. This article reviews anatomical and physiological barriers of the eye which affect the bioavailability of topical drugs. In addition, we summarize innovative topical formulations which enhance the... (More)
The prevalence of chronic fundus diseases is increasing with the aging of the general population. The treatment of these intraocular diseases relies on invasive drug delivery because of the globular structure and multiple barriers of the eye. Frequent intraocular injections bring heavy burdens to the medical care system and patients. The use of topical drugs to treat retinal diseases has always been an attractive solution. The fast development of new materials and technologies brings the possibility to develop innovative topical formulations. This article reviews anatomical and physiological barriers of the eye which affect the bioavailability of topical drugs. In addition, we summarize innovative topical formulations which enhance the permeability of drugs through the ocular surface and/or extend the drug retention time in the eye. This article also reviews the differences of eyes between different laboratory animals to address the translational challenges of preclinical models. The fast development of in vitro eye models may provide more tools to increase the clinical translationality of topical formulations for intraocular diseases. Clinical successes of topical formulations rely on continuous and collaborative efforts between different disciplines.
(Less)
- author
- Wang, Lixiang ; Zhou, Mikael Ben LU and Zhang, Hui
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Comparative anatomy of the eye, In vitro eye model, In vivo eye models, Nanoparticles, Ocular barriers, Ocular drug delivery, Ocular fundus diseases, Topical formulation
- in
- Ophthalmology and Therapy
- volume
- 10
- issue
- 3
- pages
- 30 pages
- publisher
- Springer
- external identifiers
-
- scopus:85109288078
- pmid:34218424
- ISSN
- 2193-8245
- DOI
- 10.1007/s40123-021-00365-y
- language
- English
- LU publication?
- yes
- id
- 5502e5ff-5ceb-4b3e-89f8-a8d49044ccc6
- date added to LUP
- 2021-08-12 14:35:11
- date last changed
- 2024-06-15 14:09:13
@article{5502e5ff-5ceb-4b3e-89f8-a8d49044ccc6,
abstract = {{<p>The prevalence of chronic fundus diseases is increasing with the aging of the general population. The treatment of these intraocular diseases relies on invasive drug delivery because of the globular structure and multiple barriers of the eye. Frequent intraocular injections bring heavy burdens to the medical care system and patients. The use of topical drugs to treat retinal diseases has always been an attractive solution. The fast development of new materials and technologies brings the possibility to develop innovative topical formulations. This article reviews anatomical and physiological barriers of the eye which affect the bioavailability of topical drugs. In addition, we summarize innovative topical formulations which enhance the permeability of drugs through the ocular surface and/or extend the drug retention time in the eye. This article also reviews the differences of eyes between different laboratory animals to address the translational challenges of preclinical models. The fast development of in vitro eye models may provide more tools to increase the clinical translationality of topical formulations for intraocular diseases. Clinical successes of topical formulations rely on continuous and collaborative efforts between different disciplines.</p>}},
author = {{Wang, Lixiang and Zhou, Mikael Ben and Zhang, Hui}},
issn = {{2193-8245}},
keywords = {{Comparative anatomy of the eye; In vitro eye model; In vivo eye models; Nanoparticles; Ocular barriers; Ocular drug delivery; Ocular fundus diseases; Topical formulation}},
language = {{eng}},
number = {{3}},
pages = {{465--494}},
publisher = {{Springer}},
series = {{Ophthalmology and Therapy}},
title = {{The Emerging Role of Topical Ocular Drugs to Target the Posterior Eye}},
url = {{http://dx.doi.org/10.1007/s40123-021-00365-y}},
doi = {{10.1007/s40123-021-00365-y}},
volume = {{10}},
year = {{2021}},
}