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A new imaging technology based on Compton X-ray scattering

Hernández, Ángela Saá ; González-Díaz, Diego ; Villanueva, Pablo LU orcid ; Azevedo, Carlos and Seoane, Marcos (2021) In Journal of Synchrotron Radiation 28. p.1558-1572
Abstract

A feasible implementation of a novel X-ray detector for highly energetic X-ray photons with a large solid angle coverage, optimal for the detection of Compton X-ray scattered photons, is described. The device consists of a 20 cm-thick sensitive volume filled with xenon at atmospheric pressure. When the Compton-scattered photons interact with the xenon, the released photoelectrons create clouds of secondary ionization, which are imaged using the electroluminescence produced in a custom-made multi-hole acrylic structure. Photon-by-photon counting can be achieved by processing the resulting image, taken in a continuous readout mode. Based on Geant4 simulations, by considering a realistic detector design and response, it is shown that... (More)

A feasible implementation of a novel X-ray detector for highly energetic X-ray photons with a large solid angle coverage, optimal for the detection of Compton X-ray scattered photons, is described. The device consists of a 20 cm-thick sensitive volume filled with xenon at atmospheric pressure. When the Compton-scattered photons interact with the xenon, the released photoelectrons create clouds of secondary ionization, which are imaged using the electroluminescence produced in a custom-made multi-hole acrylic structure. Photon-by-photon counting can be achieved by processing the resulting image, taken in a continuous readout mode. Based on Geant4 simulations, by considering a realistic detector design and response, it is shown that photon rates up to at least 1011photons s-1on-sample (5 μm water-equivalent cell) can be processed, limited by the spatial diffusion of the photoelectrons in the gas. Illustratively, if making use of the Rose criterion and assuming the dose partitioning theorem, it is shown how such a detector would allow obtaining 3D images of 5 μm-size unstained cells in their native environment in about 24 h, with a resolution of 36 nm.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cell imaging, Compton scattering, electroluminescence, hard X-rays, time projection chamber
in
Journal of Synchrotron Radiation
volume
28
pages
15 pages
publisher
International Union of Crystallography
external identifiers
  • scopus:85110273548
  • pmid:34475303
ISSN
0909-0495
DOI
10.1107/S1600577521005919
language
English
LU publication?
yes
id
550b53bb-c015-4285-9324-53f0c5d914bd
date added to LUP
2022-03-23 10:17:18
date last changed
2025-01-19 19:19:50
@article{550b53bb-c015-4285-9324-53f0c5d914bd,
  abstract     = {{<p>A feasible implementation of a novel X-ray detector for highly energetic X-ray photons with a large solid angle coverage, optimal for the detection of Compton X-ray scattered photons, is described. The device consists of a 20 cm-thick sensitive volume filled with xenon at atmospheric pressure. When the Compton-scattered photons interact with the xenon, the released photoelectrons create clouds of secondary ionization, which are imaged using the electroluminescence produced in a custom-made multi-hole acrylic structure. Photon-by-photon counting can be achieved by processing the resulting image, taken in a continuous readout mode. Based on Geant4 simulations, by considering a realistic detector design and response, it is shown that photon rates up to at least 10<sup>11</sup>photons s<sup>-1</sup>on-sample (5 μm water-equivalent cell) can be processed, limited by the spatial diffusion of the photoelectrons in the gas. Illustratively, if making use of the Rose criterion and assuming the dose partitioning theorem, it is shown how such a detector would allow obtaining 3D images of 5 μm-size unstained cells in their native environment in about 24 h, with a resolution of 36 nm.</p>}},
  author       = {{Hernández, Ángela Saá and González-Díaz, Diego and Villanueva, Pablo and Azevedo, Carlos and Seoane, Marcos}},
  issn         = {{0909-0495}},
  keywords     = {{cell imaging; Compton scattering; electroluminescence; hard X-rays; time projection chamber}},
  language     = {{eng}},
  month        = {{09}},
  pages        = {{1558--1572}},
  publisher    = {{International Union of Crystallography}},
  series       = {{Journal of Synchrotron Radiation}},
  title        = {{A new imaging technology based on Compton X-ray scattering}},
  url          = {{http://dx.doi.org/10.1107/S1600577521005919}},
  doi          = {{10.1107/S1600577521005919}},
  volume       = {{28}},
  year         = {{2021}},
}