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FAF and SufA: Proteins of Finegoldia magna That Modulate the Antibacterial Activity of Histones.

Murphy, Elizabeth LU ; Mohanty, Tirthankar LU and Frick, Inga-Maria LU (2013) In Journal of Innate Immunity
Abstract
Many bacterial pathogens have developed methods to overcome the defences of the host innate immune system. One such defence is the release of antimicrobial peptides (AMPs). Histones have been found to function as AMPs, in addition to their main biological function of packaging and organising DNA into nucleosomes. In this study, the Gram-positive anaerobic coccus Finegoldia magna was found to bind histones by Western blot and immunoprecipitation analysis. F. magna, which is normally a commensal of the skin and mucous membranes, is also known to act as an opportunistic pathogen and has been isolated from various clinical infection sites. It was found to bind to histones extracted from human skin epidermis through its surface and... (More)
Many bacterial pathogens have developed methods to overcome the defences of the host innate immune system. One such defence is the release of antimicrobial peptides (AMPs). Histones have been found to function as AMPs, in addition to their main biological function of packaging and organising DNA into nucleosomes. In this study, the Gram-positive anaerobic coccus Finegoldia magna was found to bind histones by Western blot and immunoprecipitation analysis. F. magna, which is normally a commensal of the skin and mucous membranes, is also known to act as an opportunistic pathogen and has been isolated from various clinical infection sites. It was found to bind to histones extracted from human skin epidermis through its surface and extracellular adhesion protein FAF. Through FAF binding, F. magna was protected from histone bactericidal activity. Furthermore, the histones were found to be degraded by SufA, a subtilisin-like extracellular serine protease of F. magna. Hence, the results of the present study will give more insight into how F. magna persists both as a commensal organism at the basement membrane of the skin and as an opportunistic pathogen during infection. © 2013 S. Karger AG, Basel. (Less)
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publication status
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Journal of Innate Immunity
publisher
Karger
external identifiers
  • pmid:24335013
  • wos:000333775000014
  • scopus:84897397119
  • pmid:24335013
ISSN
1662-811X
DOI
10.1159/000356432
language
English
LU publication?
yes
id
5535cfec-0cd6-42b5-977b-f011be3d54e1 (old id 4223756)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24335013?dopt=Abstract
date added to LUP
2016-04-01 10:21:28
date last changed
2022-04-04 17:17:47
@article{5535cfec-0cd6-42b5-977b-f011be3d54e1,
  abstract     = {{Many bacterial pathogens have developed methods to overcome the defences of the host innate immune system. One such defence is the release of antimicrobial peptides (AMPs). Histones have been found to function as AMPs, in addition to their main biological function of packaging and organising DNA into nucleosomes. In this study, the Gram-positive anaerobic coccus Finegoldia magna was found to bind histones by Western blot and immunoprecipitation analysis. F. magna, which is normally a commensal of the skin and mucous membranes, is also known to act as an opportunistic pathogen and has been isolated from various clinical infection sites. It was found to bind to histones extracted from human skin epidermis through its surface and extracellular adhesion protein FAF. Through FAF binding, F. magna was protected from histone bactericidal activity. Furthermore, the histones were found to be degraded by SufA, a subtilisin-like extracellular serine protease of F. magna. Hence, the results of the present study will give more insight into how F. magna persists both as a commensal organism at the basement membrane of the skin and as an opportunistic pathogen during infection. © 2013 S. Karger AG, Basel.}},
  author       = {{Murphy, Elizabeth and Mohanty, Tirthankar and Frick, Inga-Maria}},
  issn         = {{1662-811X}},
  language     = {{eng}},
  month        = {{12}},
  publisher    = {{Karger}},
  series       = {{Journal of Innate Immunity}},
  title        = {{FAF and SufA: Proteins of Finegoldia magna That Modulate the Antibacterial Activity of Histones.}},
  url          = {{http://dx.doi.org/10.1159/000356432}},
  doi          = {{10.1159/000356432}},
  year         = {{2013}},
}