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Are changes in meniscus volume and extrusion associated to knee osteoarthritis development? A structural equation model

Xu, D. ; van der Voet, J. ; Waarsing, J. H. ; Oei, E. H. ; Klein, S. ; Englund, M. LU orcid ; Zhang, F. LU ; Bierma-Zeinstra, S. and Runhaar, J. (2021) In Osteoarthritis and Cartilage 29(10). p.1426-1431
Abstract

Objective: To explore the interplay between (changes in) medial meniscus volume, meniscus extrusion and radiographic knee osteoarthritis (OA) development over 30 months follow-up (FU). Methods: Data from the PRevention of knee Osteoarthritis in Overweight Females study were used. This cohort included 407 middle-aged women with a body mass index ≥27 kg/m2, who were free of knee OA at baseline. Demographics were collected by questionnaires at baseline. All menisci at both baseline and FU were automatically segmented from MRI scans to obtain the meniscus volume and the change over time (delta volume). Baseline and FU meniscus body extrusion was quantitatively measured on mid-coronal proton density MR images. A structural... (More)

Objective: To explore the interplay between (changes in) medial meniscus volume, meniscus extrusion and radiographic knee osteoarthritis (OA) development over 30 months follow-up (FU). Methods: Data from the PRevention of knee Osteoarthritis in Overweight Females study were used. This cohort included 407 middle-aged women with a body mass index ≥27 kg/m2, who were free of knee OA at baseline. Demographics were collected by questionnaires at baseline. All menisci at both baseline and FU were automatically segmented from MRI scans to obtain the meniscus volume and the change over time (delta volume). Baseline and FU meniscus body extrusion was quantitatively measured on mid-coronal proton density MR images. A structural equation model was created to assess the interplay between both medial meniscus volume and central extrusion at baseline, delta volume, delta extrusion, and incident radiographic knee OA at FU. Results: The structural equation modeling yielded a fair to good fit of the data. The direct effects of both medial meniscus volume and extrusion at baseline on incident OA were statistically significant (Estimate = 0.124, p = 0.029, and Estimate = 0.194, p < 0.001, respectively). Additional indirect effects on incident radiographic OA through delta meniscus volume or delta meniscus extrusion were not statistically significant. Conclusion: Baseline medial meniscus volume and extrusion were associated to incidence of radiographic knee OA at FU in middle-aged overweight and obese women, while their changes were not involved in these effects. To prevent knee OA, interventions might need to target the onset of meniscal pathologies rather than their progression.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Knee osteoarthritis, Meniscus extrusion, Meniscus volume, MRI
in
Osteoarthritis and Cartilage
volume
29
issue
10
pages
1426 - 1431
publisher
Elsevier
external identifiers
  • pmid:34298195
  • scopus:85111720714
ISSN
1063-4584
DOI
10.1016/j.joca.2021.07.007
language
English
LU publication?
yes
id
55441dc3-9aee-44f5-93a2-38ec1c2e5a93
date added to LUP
2021-08-30 15:18:23
date last changed
2024-05-04 11:25:44
@article{55441dc3-9aee-44f5-93a2-38ec1c2e5a93,
  abstract     = {{<p>Objective: To explore the interplay between (changes in) medial meniscus volume, meniscus extrusion and radiographic knee osteoarthritis (OA) development over 30 months follow-up (FU). Methods: Data from the PRevention of knee Osteoarthritis in Overweight Females study were used. This cohort included 407 middle-aged women with a body mass index ≥27 kg/m<sup>2</sup>, who were free of knee OA at baseline. Demographics were collected by questionnaires at baseline. All menisci at both baseline and FU were automatically segmented from MRI scans to obtain the meniscus volume and the change over time (delta volume). Baseline and FU meniscus body extrusion was quantitatively measured on mid-coronal proton density MR images. A structural equation model was created to assess the interplay between both medial meniscus volume and central extrusion at baseline, delta volume, delta extrusion, and incident radiographic knee OA at FU. Results: The structural equation modeling yielded a fair to good fit of the data. The direct effects of both medial meniscus volume and extrusion at baseline on incident OA were statistically significant (Estimate = 0.124, p = 0.029, and Estimate = 0.194, p &lt; 0.001, respectively). Additional indirect effects on incident radiographic OA through delta meniscus volume or delta meniscus extrusion were not statistically significant. Conclusion: Baseline medial meniscus volume and extrusion were associated to incidence of radiographic knee OA at FU in middle-aged overweight and obese women, while their changes were not involved in these effects. To prevent knee OA, interventions might need to target the onset of meniscal pathologies rather than their progression.</p>}},
  author       = {{Xu, D. and van der Voet, J. and Waarsing, J. H. and Oei, E. H. and Klein, S. and Englund, M. and Zhang, F. and Bierma-Zeinstra, S. and Runhaar, J.}},
  issn         = {{1063-4584}},
  keywords     = {{Knee osteoarthritis; Meniscus extrusion; Meniscus volume; MRI}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1426--1431}},
  publisher    = {{Elsevier}},
  series       = {{Osteoarthritis and Cartilage}},
  title        = {{Are changes in meniscus volume and extrusion associated to knee osteoarthritis development? A structural equation model}},
  url          = {{http://dx.doi.org/10.1016/j.joca.2021.07.007}},
  doi          = {{10.1016/j.joca.2021.07.007}},
  volume       = {{29}},
  year         = {{2021}},
}