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Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants in the rat brain

Bassant, M H ; Joly, M ; Nilsson, O G LU ; Björklund, A LU and Lamour, Y (1988) In Brain Research 460(1). p.8-16
Abstract

Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants were studied in adult rats anesthetized with urethane. No specific topography of the neurons recorded was observed within the graft. The mean spontaneous activity of the grafted neurons (GNs) was relatively low (4.9 impulses/s) but not unlike that of other central neurons in situ. A large proportion of GNs fired with regular discharges, but other modes of discharge were also observed. A few rhythmically bursting GNs were recorded having a discharge pattern very much like that of the rhythmically bursting medial septal neurons. The responses of GNs to glutamate, gamma-aminobutyric acid, acetylcholine, serotonin and norepinephrine was... (More)

Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants were studied in adult rats anesthetized with urethane. No specific topography of the neurons recorded was observed within the graft. The mean spontaneous activity of the grafted neurons (GNs) was relatively low (4.9 impulses/s) but not unlike that of other central neurons in situ. A large proportion of GNs fired with regular discharges, but other modes of discharge were also observed. A few rhythmically bursting GNs were recorded having a discharge pattern very much like that of the rhythmically bursting medial septal neurons. The responses of GNs to glutamate, gamma-aminobutyric acid, acetylcholine, serotonin and norepinephrine was fairly similar to those described in other central structures.

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keywords
Acetylcholine/pharmacology, Animals, Brain/physiology, Carbachol/pharmacology, Electrophysiology/methods, Glutamates/pharmacology, Glutamic Acid, Male, Nerve Tissue/transplantation, Neurons/drug effects, Neurotransmitter Agents/pharmacology, Norepinephrine/pharmacology, Rats, Rats, Inbred Strains, Reference Values, Serotonin/pharmacology, gamma-Aminobutyric Acid/pharmacology
in
Brain Research
volume
460
issue
1
pages
8 - 16
publisher
Elsevier
external identifiers
  • pmid:2905923
  • scopus:0023680078
ISSN
0006-8993
DOI
10.1016/0006-8993(88)90424-6
language
English
LU publication?
yes
id
5545283e-9ad8-4b41-a747-fe51128ca401
date added to LUP
2019-06-25 10:24:19
date last changed
2019-11-07 08:01:17
@article{5545283e-9ad8-4b41-a747-fe51128ca401,
  abstract     = {<p>Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants were studied in adult rats anesthetized with urethane. No specific topography of the neurons recorded was observed within the graft. The mean spontaneous activity of the grafted neurons (GNs) was relatively low (4.9 impulses/s) but not unlike that of other central neurons in situ. A large proportion of GNs fired with regular discharges, but other modes of discharge were also observed. A few rhythmically bursting GNs were recorded having a discharge pattern very much like that of the rhythmically bursting medial septal neurons. The responses of GNs to glutamate, gamma-aminobutyric acid, acetylcholine, serotonin and norepinephrine was fairly similar to those described in other central structures.</p>},
  author       = {Bassant, M H and Joly, M and Nilsson, O G and Björklund, A and Lamour, Y},
  issn         = {0006-8993},
  language     = {eng},
  month        = {09},
  number       = {1},
  pages        = {8--16},
  publisher    = {Elsevier},
  series       = {Brain Research},
  title        = {Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants in the rat brain},
  url          = {http://dx.doi.org/10.1016/0006-8993(88)90424-6},
  doi          = {10.1016/0006-8993(88)90424-6},
  volume       = {460},
  year         = {1988},
}