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Aerobic capacity in adolescence is associated with time to intervention in adult men with atrial septal defects

Larsson, Lena; Rinnström, Daniel; Sandberg, Camilla; Högström, Gabriel LU ; Thilén, Ulf LU ; Nordström, Peter and Johansson, Bengt (2019) In International Journal of Cardiology 280. p.57-60
Abstract

Background: Atrial septal defect (ASD) is a congenital heart lesion that often remains undiagnosed until adulthood. The reasons for this may be multifactorial. It is, however, known that closure of a hemodynamically significant ASD improves exercise capacity. This study aimed to explore whether the aerobic capacity in late adolescence is associated with time to diagnosis and intervention in adult men with late diagnosis of an atrial shunt. Methods: The Swedish Military Conscription Service Register contains data on exercise tests performed in late adolescence. By linking these data with the National Patient Register, 254 men with a later intervention for an ASD were identified. Results: Interventions were performed at a mean of 26.5 ±... (More)

Background: Atrial septal defect (ASD) is a congenital heart lesion that often remains undiagnosed until adulthood. The reasons for this may be multifactorial. It is, however, known that closure of a hemodynamically significant ASD improves exercise capacity. This study aimed to explore whether the aerobic capacity in late adolescence is associated with time to diagnosis and intervention in adult men with late diagnosis of an atrial shunt. Methods: The Swedish Military Conscription Service Register contains data on exercise tests performed in late adolescence. By linking these data with the National Patient Register, 254 men with a later intervention for an ASD were identified. Results: Interventions were performed at a mean of 26.5 ± 7.9 years after the initial exercise tests. The mean absolute workload among those with a later diagnosed ASD was similar to those without a later diagnosed ASD (274 ± 51 W vs. 276 ± 52 W, p = 0.49). Men with a higher exercise capacity (≥1 SD) had their intervention earlier (21.9 ± 8.6 years vs. 27.5 ± 7.4 years, p < 0.001). Conclusions: The aerobic exercise capacity was similar in adolescent men with later interventions for ASD compared to the reference population. Furthermore, those with high exercise capacity appeared to be diagnosed earlier. Thus, low exercise capacity may not be a feature of ASD during adolescence, but rather develop later in life as a natural progression of the disease.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atrial septal defect, Congenital heart disease
in
International Journal of Cardiology
volume
280
pages
57 - 60
publisher
Elsevier
external identifiers
  • scopus:85059809658
ISSN
0167-5273
DOI
10.1016/j.ijcard.2018.12.073
language
English
LU publication?
yes
id
55648953-b7b2-4e5f-8aa0-a2a0f73d96b4
date added to LUP
2019-01-24 10:40:06
date last changed
2019-05-27 19:09:18
@article{55648953-b7b2-4e5f-8aa0-a2a0f73d96b4,
  abstract     = {<p>Background: Atrial septal defect (ASD) is a congenital heart lesion that often remains undiagnosed until adulthood. The reasons for this may be multifactorial. It is, however, known that closure of a hemodynamically significant ASD improves exercise capacity. This study aimed to explore whether the aerobic capacity in late adolescence is associated with time to diagnosis and intervention in adult men with late diagnosis of an atrial shunt. Methods: The Swedish Military Conscription Service Register contains data on exercise tests performed in late adolescence. By linking these data with the National Patient Register, 254 men with a later intervention for an ASD were identified. Results: Interventions were performed at a mean of 26.5 ± 7.9 years after the initial exercise tests. The mean absolute workload among those with a later diagnosed ASD was similar to those without a later diagnosed ASD (274 ± 51 W vs. 276 ± 52 W, p = 0.49). Men with a higher exercise capacity (≥1 SD) had their intervention earlier (21.9 ± 8.6 years vs. 27.5 ± 7.4 years, p &lt; 0.001). Conclusions: The aerobic exercise capacity was similar in adolescent men with later interventions for ASD compared to the reference population. Furthermore, those with high exercise capacity appeared to be diagnosed earlier. Thus, low exercise capacity may not be a feature of ASD during adolescence, but rather develop later in life as a natural progression of the disease.</p>},
  author       = {Larsson, Lena and Rinnström, Daniel and Sandberg, Camilla and Högström, Gabriel and Thilén, Ulf and Nordström, Peter and Johansson, Bengt},
  issn         = {0167-5273},
  keyword      = {Atrial septal defect,Congenital heart disease},
  language     = {eng},
  pages        = {57--60},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {Aerobic capacity in adolescence is associated with time to intervention in adult men with atrial septal defects},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2018.12.073},
  volume       = {280},
  year         = {2019},
}