Distinct haplotype structure at the innate immune receptor Toll-like receptor 2 across bank vole populations and lineages in Europe
(2015) In Biological Journal of the Linnean Society 116(1). p.124-133- Abstract
- Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplotypes from all populations grouped in four clearly... (More)
- Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplotypes from all populations grouped in four clearly differentiated clusters, with the three main clusters co-occurring in at least three previously described mitochondrial lineages. This pattern indicates that the distinct TLR2 haplotype structure may precede the split of the mitochondrial lineages 0.19-0.56Mya and suggests that haplotype clusters at this innate immune receptor are maintained over prolonged time in wild bank vole populations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7975726
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- balancing selection, diversity, gene evolution, immunogenetics, maintenance of genetic variation, Myodes glareolus, parasite resistance, phylogeography, rodents, TLR2
- in
- Biological Journal of the Linnean Society
- volume
- 116
- issue
- 1
- pages
- 124 - 133
- publisher
- Oxford University Press
- external identifiers
-
- wos:000359294700010
- scopus:84938749646
- ISSN
- 0024-4066
- DOI
- 10.1111/bij.12593
- language
- English
- LU publication?
- yes
- id
- 557515cc-4103-4d0e-9a5a-d8c61a6dfeb7 (old id 7975726)
- date added to LUP
- 2016-04-01 11:13:27
- date last changed
- 2022-02-03 00:43:46
@article{557515cc-4103-4d0e-9a5a-d8c61a6dfeb7, abstract = {{Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplotypes from all populations grouped in four clearly differentiated clusters, with the three main clusters co-occurring in at least three previously described mitochondrial lineages. This pattern indicates that the distinct TLR2 haplotype structure may precede the split of the mitochondrial lineages 0.19-0.56Mya and suggests that haplotype clusters at this innate immune receptor are maintained over prolonged time in wild bank vole populations.}}, author = {{Morger, Jennifer and Råberg, Lars and Hille, Sabine M. and Helsen, Sanne and Stefka, Jan and Al-Sabi, Mohammad M. and Kapel, Christian M. O. and Mappes, Tapio and Essbauer, Sandra and Ulrich, Rainer G. and Bartolommei, Paola and Mortelliti, Alessio and Balciauskas, Linas and van den Brink, Nico W. and Remy, Alice and Bajer, Anna and Cheprakov, Mihail and Korva, Misa and Garcia-Perez, Ana L. and Biek, Roman and Withenshaw, Susan and Tschirren, Barbara}}, issn = {{0024-4066}}, keywords = {{balancing selection; diversity; gene evolution; immunogenetics; maintenance of genetic variation; Myodes glareolus; parasite resistance; phylogeography; rodents; TLR2}}, language = {{eng}}, number = {{1}}, pages = {{124--133}}, publisher = {{Oxford University Press}}, series = {{Biological Journal of the Linnean Society}}, title = {{Distinct haplotype structure at the innate immune receptor Toll-like receptor 2 across bank vole populations and lineages in Europe}}, url = {{http://dx.doi.org/10.1111/bij.12593}}, doi = {{10.1111/bij.12593}}, volume = {{116}}, year = {{2015}}, }