Short and long-term associations between serum proteins linked to cardiovascular disease and particle exposure among constructions workers
Gliga, Anda R. ; Grahn, Karin ; Gustavsson, Per ; Ljungman, Petter ; Albin, Maria LU ; Selander, Jenny and Broberg, Karin LU
(2023)
In Scandinavian Journal of Work, Environment and Health
49(2).
p.145-154
- Abstract
Objectives Construction workers are exposed to respirable dust, including respirable crystalline silica (RCS), which is a potential risk factor for cardiovascular disease (CVD). The aim of this study was to evaluate whether exposure to particles among construction workers is associated with short-and long-term alterations in CVD-related serum proteins. Methods Using proximity extension assay, we measured 92 serum proteins linked to CVD among active male construction workers (N=65, non-smokers) sampled on two occasions: during work and after vacation. First, we used linear models to identify short-term changes in proteins associated with particle exposure (assessed as respirable dust and RCS) during work. Secondly, we used linear mixed... (More)
Objectives Construction workers are exposed to respirable dust, including respirable crystalline silica (RCS), which is a potential risk factor for cardiovascular disease (CVD). The aim of this study was to evaluate whether exposure to particles among construction workers is associated with short-and long-term alterations in CVD-related serum proteins. Methods Using proximity extension assay, we measured 92 serum proteins linked to CVD among active male construction workers (N=65, non-smokers) sampled on two occasions: during work and after vacation. First, we used linear models to identify short-term changes in proteins associated with particle exposure (assessed as respirable dust and RCS) during work. Secondly, we used linear mixed models to evaluate whether these associations were long-term, ie, persistent after vacation. Results The median exposure to respirable dust and RCS during work were 0.25 mg/m3 and 0.01 mg/m3, respec-tively. Respirable dust was associated with short-term changes in six proteins (tissue factor, growth hormone, heme oxygenase-1, dickkopf-related protein-1, platelet-derived growth factor-B, stem cell factor); long-term associations were observed for the former three proteins. RCS was associated with short-term changes in five proteins (carcinoembryonic antigen-related cell adhesion molecule-8, hydroxyacid oxidase-1, tissue factor, car-bonic anhydrase-5A, lectin-like oxidized LDL receptor-1); long-term associations were observed for the former four proteins. Conclusions Moderate exposure to particles in the construction industry is associated with both short-and long-term changes in circulating CVD-related proteins. Further studies are needed to evaluate if these changes are predictors of occupationally induced clinical CVD.
(Less)
- author
- Gliga, Anda R.
; Grahn, Karin
; Gustavsson, Per
; Ljungman, Petter
; Albin, Maria
LU
; Selander, Jenny
and Broberg, Karin
LU
- organization
- publishing date
- 2023-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biomarker, cardiovascular biomarker, occupational exposure, respirable crystalline silica
- in
- Scandinavian Journal of Work, Environment and Health
- volume
- 49
- issue
- 2
- pages
- 10 pages
- publisher
- Finnish Institute of Occupational Health
- external identifiers
-
- pmid:36409488
- scopus:85149053334
- ISSN
- 0355-3140
- DOI
- 10.5271/sjweh.4071
- language
- English
- LU publication?
- yes
- id
- 55869b70-311b-4d31-9d33-f6dcd2fb64d6
- date added to LUP
- 2024-01-12 13:23:45
- date last changed
- 2024-04-13 06:51:58
@article{55869b70-311b-4d31-9d33-f6dcd2fb64d6,
abstract = {{<p>Objectives Construction workers are exposed to respirable dust, including respirable crystalline silica (RCS), which is a potential risk factor for cardiovascular disease (CVD). The aim of this study was to evaluate whether exposure to particles among construction workers is associated with short-and long-term alterations in CVD-related serum proteins. Methods Using proximity extension assay, we measured 92 serum proteins linked to CVD among active male construction workers (N=65, non-smokers) sampled on two occasions: during work and after vacation. First, we used linear models to identify short-term changes in proteins associated with particle exposure (assessed as respirable dust and RCS) during work. Secondly, we used linear mixed models to evaluate whether these associations were long-term, ie, persistent after vacation. Results The median exposure to respirable dust and RCS during work were 0.25 mg/m<sup>3</sup> and 0.01 mg/m<sup>3</sup>, respec-tively. Respirable dust was associated with short-term changes in six proteins (tissue factor, growth hormone, heme oxygenase-1, dickkopf-related protein-1, platelet-derived growth factor-B, stem cell factor); long-term associations were observed for the former three proteins. RCS was associated with short-term changes in five proteins (carcinoembryonic antigen-related cell adhesion molecule-8, hydroxyacid oxidase-1, tissue factor, car-bonic anhydrase-5A, lectin-like oxidized LDL receptor-1); long-term associations were observed for the former four proteins. Conclusions Moderate exposure to particles in the construction industry is associated with both short-and long-term changes in circulating CVD-related proteins. Further studies are needed to evaluate if these changes are predictors of occupationally induced clinical CVD.</p>}},
author = {{Gliga, Anda R. and Grahn, Karin and Gustavsson, Per and Ljungman, Petter and Albin, Maria and Selander, Jenny and Broberg, Karin}},
issn = {{0355-3140}},
keywords = {{biomarker; cardiovascular biomarker; occupational exposure; respirable crystalline silica}},
language = {{eng}},
month = {{03}},
number = {{2}},
pages = {{145--154}},
publisher = {{Finnish Institute of Occupational Health}},
series = {{Scandinavian Journal of Work, Environment and Health}},
title = {{Short and long-term associations between serum proteins linked to cardiovascular disease and particle exposure among constructions workers}},
url = {{http://dx.doi.org/10.5271/sjweh.4071}},
doi = {{10.5271/sjweh.4071}},
volume = {{49}},
year = {{2023}},
}