Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography
Arboleda, Carolina ; Wang, Zhentian ; Koehler, Thomas ; Martens, Gerhard ; Van Stevendaal, Udo ; Bartels, Matthias ; Villanueva-Perez, Pablo LU
; Roessl, Ewald
and Stampanoni, Marco
(2017)
In Optics Express
25(6).
p.6349-6364
- Abstract
An X-ray grating interferometer (GI) suitable for clinical mammography must comply with quite strict dose, scanning time and geometry limitations, while being able to detect tumors, microcalcifications and other abnormalities. Such a design task is not straightforward, since obtaining optimal phase-contrast and dark-field signals with clinically compatible doses and geometrical constraints is remarkably challenging. In this work, we present a wave propagation based optimization that uses the phase and dark-field sensitivities as figures of merit. This method was used to calculate the optimal interferometer designs for a commercial mammography setup. Its accuracy was validated by measuring the visibility of polycarbonate samples of... (More)
An X-ray grating interferometer (GI) suitable for clinical mammography must comply with quite strict dose, scanning time and geometry limitations, while being able to detect tumors, microcalcifications and other abnormalities. Such a design task is not straightforward, since obtaining optimal phase-contrast and dark-field signals with clinically compatible doses and geometrical constraints is remarkably challenging. In this work, we present a wave propagation based optimization that uses the phase and dark-field sensitivities as figures of merit. This method was used to calculate the optimal interferometer designs for a commercial mammography setup. Its accuracy was validated by measuring the visibility of polycarbonate samples of different thicknesses on a Talbot-Lau interferometer installed on this device and considering some of the most common grating imperfections to be able to reproduce the experimental values. The optimization method outcomes indicate that small grating pitches are required to boost sensitivity in such a constrained setup and that there is a different optimal scenario for each signal type.
(Less)
- author
- Arboleda, Carolina
; Wang, Zhentian
; Koehler, Thomas
; Martens, Gerhard
; Van Stevendaal, Udo
; Bartels, Matthias
; Villanueva-Perez, Pablo
LU
; Roessl, Ewald
and Stampanoni, Marco
- publishing date
- 2017-03-20
- type
- Contribution to journal
- publication status
- published
- in
- Optics Express
- volume
- 25
- issue
- 6
- pages
- 16 pages
- publisher
- Optical Society of America
- external identifiers
-
- scopus:85015787384
- pmid:28380987
- ISSN
- 1094-4087
- DOI
- 10.1364/OE.25.006349
- language
- English
- LU publication?
- no
- id
- 558e114f-8924-40b4-a6d7-abbc4fd3fd45
- date added to LUP
- 2019-03-29 16:55:19
- date last changed
- 2024-02-14 20:38:50
@article{558e114f-8924-40b4-a6d7-abbc4fd3fd45,
abstract = {{<p>An X-ray grating interferometer (GI) suitable for clinical mammography must comply with quite strict dose, scanning time and geometry limitations, while being able to detect tumors, microcalcifications and other abnormalities. Such a design task is not straightforward, since obtaining optimal phase-contrast and dark-field signals with clinically compatible doses and geometrical constraints is remarkably challenging. In this work, we present a wave propagation based optimization that uses the phase and dark-field sensitivities as figures of merit. This method was used to calculate the optimal interferometer designs for a commercial mammography setup. Its accuracy was validated by measuring the visibility of polycarbonate samples of different thicknesses on a Talbot-Lau interferometer installed on this device and considering some of the most common grating imperfections to be able to reproduce the experimental values. The optimization method outcomes indicate that small grating pitches are required to boost sensitivity in such a constrained setup and that there is a different optimal scenario for each signal type.</p>}},
author = {{Arboleda, Carolina and Wang, Zhentian and Koehler, Thomas and Martens, Gerhard and Van Stevendaal, Udo and Bartels, Matthias and Villanueva-Perez, Pablo and Roessl, Ewald and Stampanoni, Marco}},
issn = {{1094-4087}},
language = {{eng}},
month = {{03}},
number = {{6}},
pages = {{6349--6364}},
publisher = {{Optical Society of America}},
series = {{Optics Express}},
title = {{Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography}},
url = {{http://dx.doi.org/10.1364/OE.25.006349}},
doi = {{10.1364/OE.25.006349}},
volume = {{25}},
year = {{2017}},
}