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Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography

Arboleda, Carolina; Wang, Zhentian; Koehler, Thomas; Martens, Gerhard; Van Stevendaal, Udo; Bartels, Matthias; Villanueva-Perez, Pablo LU ; Roessl, Ewald and Stampanoni, Marco (2017) In Optics Express 25(6). p.6349-6364
Abstract

An X-ray grating interferometer (GI) suitable for clinical mammography must comply with quite strict dose, scanning time and geometry limitations, while being able to detect tumors, microcalcifications and other abnormalities. Such a design task is not straightforward, since obtaining optimal phase-contrast and dark-field signals with clinically compatible doses and geometrical constraints is remarkably challenging. In this work, we present a wave propagation based optimization that uses the phase and dark-field sensitivities as figures of merit. This method was used to calculate the optimal interferometer designs for a commercial mammography setup. Its accuracy was validated by measuring the visibility of polycarbonate samples of... (More)

An X-ray grating interferometer (GI) suitable for clinical mammography must comply with quite strict dose, scanning time and geometry limitations, while being able to detect tumors, microcalcifications and other abnormalities. Such a design task is not straightforward, since obtaining optimal phase-contrast and dark-field signals with clinically compatible doses and geometrical constraints is remarkably challenging. In this work, we present a wave propagation based optimization that uses the phase and dark-field sensitivities as figures of merit. This method was used to calculate the optimal interferometer designs for a commercial mammography setup. Its accuracy was validated by measuring the visibility of polycarbonate samples of different thicknesses on a Talbot-Lau interferometer installed on this device and considering some of the most common grating imperfections to be able to reproduce the experimental values. The optimization method outcomes indicate that small grating pitches are required to boost sensitivity in such a constrained setup and that there is a different optimal scenario for each signal type.

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author
publishing date
type
Contribution to journal
publication status
published
in
Optics Express
volume
25
issue
6
pages
16 pages
publisher
OSA
external identifiers
  • scopus:85015787384
ISSN
1094-4087
DOI
10.1364/OE.25.006349
language
English
LU publication?
no
id
558e114f-8924-40b4-a6d7-abbc4fd3fd45
date added to LUP
2019-03-29 16:55:19
date last changed
2019-06-19 04:10:16
@article{558e114f-8924-40b4-a6d7-abbc4fd3fd45,
  abstract     = {<p>An X-ray grating interferometer (GI) suitable for clinical mammography must comply with quite strict dose, scanning time and geometry limitations, while being able to detect tumors, microcalcifications and other abnormalities. Such a design task is not straightforward, since obtaining optimal phase-contrast and dark-field signals with clinically compatible doses and geometrical constraints is remarkably challenging. In this work, we present a wave propagation based optimization that uses the phase and dark-field sensitivities as figures of merit. This method was used to calculate the optimal interferometer designs for a commercial mammography setup. Its accuracy was validated by measuring the visibility of polycarbonate samples of different thicknesses on a Talbot-Lau interferometer installed on this device and considering some of the most common grating imperfections to be able to reproduce the experimental values. The optimization method outcomes indicate that small grating pitches are required to boost sensitivity in such a constrained setup and that there is a different optimal scenario for each signal type.</p>},
  author       = {Arboleda, Carolina and Wang, Zhentian and Koehler, Thomas and Martens, Gerhard and Van Stevendaal, Udo and Bartels, Matthias and Villanueva-Perez, Pablo and Roessl, Ewald and Stampanoni, Marco},
  issn         = {1094-4087},
  language     = {eng},
  month        = {03},
  number       = {6},
  pages        = {6349--6364},
  publisher    = {OSA},
  series       = {Optics Express},
  title        = {Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography},
  url          = {http://dx.doi.org/10.1364/OE.25.006349},
  volume       = {25},
  year         = {2017},
}