Synthesis of Boronic Ester γ‐Lactam Building Blocks
(2021) In Advanced Synthesis & Catalysis 363(9). p.2392-2395- Abstract
- Saturated heterocycles are found widely in biologically active compounds such as medicinal drugs and agrochemicals. However, boronic acid-derived building blocks for these structures have limited availability, particularly in comparison to heteroaromatic boronic acids. We report the preparation of boronic ester γ-lactams through a Cu-catalysed conjugate borylation-cyclisation protocol. Using a chiral catalyst, this can be performed in high enantioselectivity. Exploration of the further transformations of these reagents suggest that the boronic esters have much potential as chemical building blocks.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/55a65f07-6bf5-4571-bd9d-0d5f251f7bbe
- author
- Rodgers, George ; Wilson, Ellen J. LU ; Robertson, Craig C. ; Cox, Daniel J. and Partridge, Benjamin M.
- publishing date
- 2021-04-27
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Advanced Synthesis & Catalysis
- volume
- 363
- issue
- 9
- pages
- 4 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85097604216
- ISSN
- 1615-4169
- DOI
- 10.1002/adsc.202001339
- language
- English
- LU publication?
- no
- id
- 55a65f07-6bf5-4571-bd9d-0d5f251f7bbe
- date added to LUP
- 2024-06-17 13:36:03
- date last changed
- 2024-06-18 04:02:41
@article{55a65f07-6bf5-4571-bd9d-0d5f251f7bbe, abstract = {{Saturated heterocycles are found widely in biologically active compounds such as medicinal drugs and agrochemicals. However, boronic acid-derived building blocks for these structures have limited availability, particularly in comparison to heteroaromatic boronic acids. We report the preparation of boronic ester γ-lactams through a Cu-catalysed conjugate borylation-cyclisation protocol. Using a chiral catalyst, this can be performed in high enantioselectivity. Exploration of the further transformations of these reagents suggest that the boronic esters have much potential as chemical building blocks.}}, author = {{Rodgers, George and Wilson, Ellen J. and Robertson, Craig C. and Cox, Daniel J. and Partridge, Benjamin M.}}, issn = {{1615-4169}}, language = {{eng}}, month = {{04}}, number = {{9}}, pages = {{2392--2395}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Advanced Synthesis & Catalysis}}, title = {{Synthesis of Boronic Ester γ‐Lactam Building Blocks}}, url = {{http://dx.doi.org/10.1002/adsc.202001339}}, doi = {{10.1002/adsc.202001339}}, volume = {{363}}, year = {{2021}}, }